JPS5452069A - Prostaglandin i2 analog compound and its preparation - Google Patents
Prostaglandin i2 analog compound and its preparationInfo
- Publication number
- JPS5452069A JPS5452069A JP11613877A JP11613877A JPS5452069A JP S5452069 A JPS5452069 A JP S5452069A JP 11613877 A JP11613877 A JP 11613877A JP 11613877 A JP11613877 A JP 11613877A JP S5452069 A JPS5452069 A JP S5452069A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkyl
- prostaglandin
- preparation
- analog compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 Prostaglandin i2 analog compound Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- 206010061216 Infarction Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 230000015271 coagulation Effects 0.000 abstract 1
- 238000005345 coagulation Methods 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 230000007574 infarction Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 230000002040 relaxant effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Prostaglandin I2 analog compound I (Y is ethylene, trans- venylene; R1 is H, 1-12C alkyl; R2 is H, methyl, etc.; R3 is single bond, 1-4C alkylene; R4 is H, 1-8C alkyl, etc.; wary line is α,β,α+β-cordination; C5=C5 is Z); their cyclodextrin-clathrate compound, and when R1 is H, non-toxic salts of the acid.
EXAMPLE: (5Z,13E)-(9α,11α,15S)-6,9-eptithio-11,15-dihydroxyprosta-5,13-dienoic acid methyl ester.
USE: The compounds have arthery relaxing effect and esp. human blood platelet coagulation inhibiting effect, and useful as remedies for artheriosclerosis, cardiac infarction, thrombosis,etc.
PROCESS: The compound I is prepared by converting the C9-OH of a compound II (R5 is H, 1-4C alkyl; R7 is benzoyl, etc.) to alkylsulfonyl, reacting with a compound III (R6 is 1-4C lakyl; Q is O, S), and further reacting under conditions.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11613877A JPS5452069A (en) | 1977-09-29 | 1977-09-29 | Prostaglandin i2 analog compound and its preparation |
| DE19782841360 DE2841360A1 (en) | 1977-09-29 | 1978-09-22 | PROSTAGLANDIN-I DEEP 2 -ANALOGS |
| IT28156/78A IT1099217B (en) | 1977-09-29 | 1978-09-27 | PROSTAGLANDINE ANALOGS I2 |
| GB7838358A GB2007218B (en) | 1977-09-29 | 1978-09-27 | Prostaglandin 1 anologues |
| FR7827768A FR2404637A1 (en) | 1977-09-29 | 1978-09-28 | PROSTAGLANDIN ANALOGUES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11613877A JPS5452069A (en) | 1977-09-29 | 1977-09-29 | Prostaglandin i2 analog compound and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5452069A true JPS5452069A (en) | 1979-04-24 |
Family
ID=14679665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11613877A Pending JPS5452069A (en) | 1977-09-29 | 1977-09-29 | Prostaglandin i2 analog compound and its preparation |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS5452069A (en) |
| DE (1) | DE2841360A1 (en) |
| FR (1) | FR2404637A1 (en) |
| GB (1) | GB2007218B (en) |
| IT (1) | IT1099217B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55500346A (en) * | 1978-03-13 | 1980-06-19 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58164512A (en) * | 1982-03-25 | 1983-09-29 | Ono Pharmaceut Co Ltd | Remedy for cell disorder containing prostaglandin analog compound as an active ingredient |
-
1977
- 1977-09-29 JP JP11613877A patent/JPS5452069A/en active Pending
-
1978
- 1978-09-22 DE DE19782841360 patent/DE2841360A1/en not_active Withdrawn
- 1978-09-27 GB GB7838358A patent/GB2007218B/en not_active Expired
- 1978-09-27 IT IT28156/78A patent/IT1099217B/en active
- 1978-09-28 FR FR7827768A patent/FR2404637A1/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55500346A (en) * | 1978-03-13 | 1980-06-19 |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2404637B1 (en) | 1982-02-05 |
| IT7828156A0 (en) | 1978-09-27 |
| DE2841360A1 (en) | 1979-04-05 |
| IT1099217B (en) | 1985-09-18 |
| FR2404637A1 (en) | 1979-04-27 |
| GB2007218A (en) | 1979-05-16 |
| GB2007218B (en) | 1982-08-04 |
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