FR2404637A1 - PROSTAGLANDIN ANALOGUES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
PROSTAGLANDIN ANALOGUES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- FR2404637A1 FR2404637A1 FR7827768A FR7827768A FR2404637A1 FR 2404637 A1 FR2404637 A1 FR 2404637A1 FR 7827768 A FR7827768 A FR 7827768A FR 7827768 A FR7827768 A FR 7827768A FR 2404637 A1 FR2404637 A1 FR 2404637A1
- Authority
- FR
- France
- Prior art keywords
- alkyl
- pharmaceutical compositions
- compositions containing
- prostaglandin analogues
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- -1 R ** 2 = H Chemical group 0.000 abstract 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne de nouveaux analogues de prostaglandines. Ces composes ont la formule ci-dessous, dans laquelle Y = éthylène ou vinylène trans, R**1 H ou alcoyle, R**2 = H, méthyle ou éthyle, R**3 = liaison simple ou alcoylène, R**4 = H, alcoyle, cycloalcoyle alcoylé ou non, ou phényle ou phénoxy substitués ou non, à l'exclusion de la thiaprostacycline et de son ester méthylique. Applications pharmacologiques en particulier dans le domaine cardiovasculaire.The invention relates to novel prostaglandin analogs. These compounds have the formula below, in which Y = ethylene or trans vinylene, R ** 1 H or alkyl, R ** 2 = H, methyl or ethyl, R ** 3 = single bond or alkylene, R ** 4 = H, alkyl, alkyl or unsubstituted cycloalkyl, or substituted or unsubstituted phenyl or phenoxy, excluding thiaprostacycline and its methyl ester. Pharmacological applications in particular in the cardiovascular field.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11613877A JPS5452069A (en) | 1977-09-29 | 1977-09-29 | Prostaglandin i2 analog compound and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2404637A1 true FR2404637A1 (en) | 1979-04-27 |
| FR2404637B1 FR2404637B1 (en) | 1982-02-05 |
Family
ID=14679665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7827768A Granted FR2404637A1 (en) | 1977-09-29 | 1978-09-28 | PROSTAGLANDIN ANALOGUES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS5452069A (en) |
| DE (1) | DE2841360A1 (en) |
| FR (1) | FR2404637A1 (en) |
| GB (1) | GB2007218B (en) |
| IT (1) | IT1099217B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4291166A (en) * | 1978-03-13 | 1981-09-22 | Research Corporation | Pharmaceutically active 6,9-thiaprostacyclin analogs and derivatives thereof |
| JPS58164512A (en) * | 1982-03-25 | 1983-09-29 | Ono Pharmaceut Co Ltd | Remedy for cell disorder containing prostaglandin analog compound as an active ingredient |
-
1977
- 1977-09-29 JP JP11613877A patent/JPS5452069A/en active Pending
-
1978
- 1978-09-22 DE DE19782841360 patent/DE2841360A1/en not_active Withdrawn
- 1978-09-27 IT IT28156/78A patent/IT1099217B/en active
- 1978-09-27 GB GB7838358A patent/GB2007218B/en not_active Expired
- 1978-09-28 FR FR7827768A patent/FR2404637A1/en active Granted
Non-Patent Citations (2)
| Title |
|---|
| EXBK/77 * |
| EXBK/78 * |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2007218B (en) | 1982-08-04 |
| IT1099217B (en) | 1985-09-18 |
| GB2007218A (en) | 1979-05-16 |
| DE2841360A1 (en) | 1979-04-05 |
| FR2404637B1 (en) | 1982-02-05 |
| IT7828156A0 (en) | 1978-09-27 |
| JPS5452069A (en) | 1979-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |