ES8307212A1 - Un procedimiento para la preparacion de derivados de acidos alcanoicos. - Google Patents
Un procedimiento para la preparacion de derivados de acidos alcanoicos.Info
- Publication number
- ES8307212A1 ES8307212A1 ES513221A ES513221A ES8307212A1 ES 8307212 A1 ES8307212 A1 ES 8307212A1 ES 513221 A ES513221 A ES 513221A ES 513221 A ES513221 A ES 513221A ES 8307212 A1 ES8307212 A1 ES 8307212A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- unsubstituted
- carbon atoms
- aryl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title 1
- 239000005864 Sulphur Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- -1 where R3 is H Chemical group 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 101100294106 Caenorhabditis elegans nhr-3 gene Proteins 0.000 abstract 1
- 101100294115 Caenorhabditis elegans nhr-4 gene Proteins 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 230000001364 causal effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B45/00—Formation or introduction of functional groups containing sulfur
- C07B45/04—Formation or introduction of functional groups containing sulfur of sulfonyl or sulfinyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
- C07D303/42—Acyclic compounds having a chain of seven or more carbon atoms, e.g. epoxidised fats
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/04—Seven-membered rings not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/5304—Acyclic saturated phosphine oxides or thioxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/5325—Aromatic phosphine oxides or thioxides (P-C aromatic linkage)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACIDOS ALCANOICOS, DE FORMULA (I), EN LA QUE Y, R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN CLORURO DE SULFENILO DE FORMULA R SCL, EN LAS QUE R Y R W TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UNA BASE, TAL COMO UNA AMINA TERCIARIA, A UNA TEMPERATURA ENTRE -60 C Y 60 C; EL COMPUESTO OBTENIDO SE SEPARA EN FORMA DE LACTONA O SE HIDROLIZA AL ACIDO LIBRE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE TRASTORNOS ALERGICOS/INFLAMATORIOS DEBIDOS A LA SRS-A.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8118720 | 1981-06-18 | ||
GB8213211 | 1982-05-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES513221A0 ES513221A0 (es) | 1983-07-01 |
ES8307212A1 true ES8307212A1 (es) | 1983-07-01 |
Family
ID=26279835
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES513221A Expired ES8307212A1 (es) | 1981-06-18 | 1982-06-17 | Un procedimiento para la preparacion de derivados de acidos alcanoicos. |
ES520670A Expired ES8404307A1 (es) | 1981-06-18 | 1983-03-16 | Un procedimiento para la preparacion de derivados de acidos alcanoicos. |
ES520671A Expired ES8404322A1 (es) | 1981-06-18 | 1983-03-16 | Un procedimiento para la preparacion de derivados de acidos alcanoicos. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES520670A Expired ES8404307A1 (es) | 1981-06-18 | 1983-03-16 | Un procedimiento para la preparacion de derivados de acidos alcanoicos. |
ES520671A Expired ES8404322A1 (es) | 1981-06-18 | 1983-03-16 | Un procedimiento para la preparacion de derivados de acidos alcanoicos. |
Country Status (23)
Country | Link |
---|---|
US (1) | US4513005A (es) |
EP (1) | EP0068739B1 (es) |
KR (1) | KR890000622B1 (es) |
AU (1) | AU549814B2 (es) |
BG (1) | BG37226A3 (es) |
CA (1) | CA1224795A (es) |
CS (1) | CS241109B2 (es) |
DD (1) | DD202697A5 (es) |
DE (1) | DE3261237D1 (es) |
DK (1) | DK271682A (es) |
ES (3) | ES8307212A1 (es) |
FI (1) | FI77847C (es) |
GB (1) | GB2101594B (es) |
GR (1) | GR76838B (es) |
HU (1) | HU192105B (es) |
IE (1) | IE53522B1 (es) |
IL (1) | IL66056A0 (es) |
NZ (1) | NZ200984A (es) |
PH (1) | PH23051A (es) |
PL (4) | PL137766B1 (es) |
PT (1) | PT75058B (es) |
RO (1) | RO83706B (es) |
ZA (1) | ZA824294B (es) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2480747A1 (fr) * | 1980-04-17 | 1981-10-23 | Roques Bernard | Derives d'acides amines et leur application therapeutique |
US4537723A (en) * | 1982-02-04 | 1985-08-27 | The Upjohn Company | Derivatives of leukotrienes A and C |
US4775662A (en) * | 1983-03-07 | 1988-10-04 | Smithkline Beckman Corporation | Leukotriene antagonists |
DK130984A (da) * | 1983-03-07 | 1984-09-08 | Smithkline Beckman Corp | Leukotrien-antagonister |
EP0123543B1 (en) * | 1983-04-21 | 1988-02-03 | Merck Frosst Canada Inc. | Leukotriene antagonists, their production and use and compositions containing them |
US4609744A (en) * | 1983-04-21 | 1986-09-02 | Merck Frosst Canada Inc. | 4-oxo-benzopyran carboxylic acids |
US5017583A (en) * | 1983-04-21 | 1991-05-21 | Merck Frosst Canada, Inc. | Leukotriene antagonists |
US4720505A (en) * | 1983-06-27 | 1988-01-19 | Merck Frosst Canada, Inc. | Leukotriene antagonists |
GB8320943D0 (en) * | 1983-08-03 | 1983-09-07 | Lilly Industries Ltd | Organic compounds |
US4761425A (en) * | 1983-12-27 | 1988-08-02 | Merck Frosst Canada, Inc. | Leukotriene antagonists |
AU572615B2 (en) | 1983-12-27 | 1988-05-12 | Sony Corporation | Electrically conductive adhesive sheet circuit board and electrical connection structure |
CA1288107C (en) * | 1983-12-27 | 1991-08-27 | Yves Girard | Leukotriene antagonists |
US4769386A (en) * | 1984-06-18 | 1988-09-06 | Smithkline Beckman Corporation | Imidazolylthioalkenoic acids and -alkenols and leukotriene antagonistic composition containing them |
ES8606260A1 (es) * | 1984-06-28 | 1986-04-16 | Ciba Geigy Ag | Procedimiento para la obtencion de tioeteres alifaticos |
US4758594A (en) * | 1984-07-18 | 1988-07-19 | Schering Corporation | Inhibitors of slow reacting substance of anaphylaxis |
US4798842A (en) * | 1984-07-18 | 1989-01-17 | Schering Corporation | Inhibitors of slow reacting substance of anaphylaxis |
US4988716A (en) * | 1984-07-18 | 1991-01-29 | Schering Corporation | Inhibitors of slow reacting substance of anaphylaxis |
US4889873A (en) * | 1984-07-18 | 1989-12-26 | Schering Corporation | Inhibitors of slow reacting substance of anaphylaxis |
GB8502258D0 (en) * | 1985-01-30 | 1985-02-27 | Lilly Industries Ltd | Organic compounds |
US4937253A (en) * | 1985-04-19 | 1990-06-26 | Smithkline Beecham Corporation | Ester prodrugs |
EP0202759B1 (en) * | 1985-04-19 | 1990-06-20 | Smithkline Beecham Corporation | Leukotriene antagonists |
US4939279A (en) * | 1985-04-19 | 1990-07-03 | Smithkline Beecham Corporation | Leukotriene antagonists |
US4874792A (en) * | 1985-04-19 | 1989-10-17 | Smithkline Beckman Corporation | Thiophenyl Alkanoic acids useful as leukotriene antagonists |
US4990526A (en) * | 1985-06-18 | 1991-02-05 | Merck Frosst Canada, Inc. | Leukotriene antagonists, compositions and methods of use thereof |
CA1309557C (en) | 1985-06-18 | 1992-10-27 | Robert N. Young | Leukotriene antagonists |
US4696946A (en) * | 1985-08-30 | 1987-09-29 | Schering Corporation | Topical Treatment of hyperproliferative skin diseases |
US4783483A (en) * | 1985-10-03 | 1988-11-08 | Ortho Pharmaceutical Corporation | Epoxides useful as antiallergic agents |
US4808572A (en) * | 1985-12-06 | 1989-02-28 | Ciba-Geigy Corporation | α-Hydroxy thioethers |
KR870011086A (ko) * | 1986-05-29 | 1987-12-19 | 벤자민 에프. 램버트 | 포스포리파제 a₂억제제 및 그의 합성방법 |
GB8709547D0 (en) * | 1987-04-22 | 1987-05-28 | Lilly Industries Ltd | Organic compounds |
DE3724735A1 (de) * | 1987-07-25 | 1989-02-02 | Hoechst Ag | Leukotrienantagonisten, verfahren zu ihrer herstellung, ihre anwendung zur behandlung von krankheiten, sowie vorprodukte |
DE3724669A1 (de) * | 1987-07-25 | 1989-02-02 | Hoechst Ag | Leukotrienantagonisten, verfahren zu ihrer herstellung und ihre anwendung zur behandlung von krankheiten |
GB8725260D0 (en) * | 1987-10-28 | 1987-12-02 | Lilly Industries Ltd | Organic compounds |
AU610528B2 (en) * | 1987-10-29 | 1991-05-23 | Smithkline Beckman Corporation | Leukotriene antagonists |
GB8807016D0 (en) * | 1988-03-24 | 1988-04-27 | Lilly Industries Ltd | Organic compounds & their pharmaceutical use |
US5073571A (en) * | 1988-06-16 | 1991-12-17 | Washington University | Method of inhibiting virus |
US4954513A (en) * | 1988-12-23 | 1990-09-04 | Smithkline Beecham Corporation | Leukotriene antagonists |
US5149835A (en) * | 1989-04-27 | 1992-09-22 | University Of New Mexico | Substituted mevalonolactones, and methods for stereoselective preparation thereof and desmethyl homologues thereof |
EP0410244A1 (en) * | 1989-07-27 | 1991-01-30 | Bayer Ag | Leukotriene antagonists |
US5238683A (en) * | 1989-11-24 | 1993-08-24 | The United States Of America As Represented By The Department Of Health And Human Services | Aerosol preparation of glutathione and a method for augmenting glutathione level in lungs |
WO1991017149A1 (en) * | 1990-05-01 | 1991-11-14 | Smithkline Beecham Corporation | 3-naphthyl-3-carboxyalkylthio or oxy substituted alkanoic acid leukotriene antagonists |
US7312247B2 (en) | 2001-03-27 | 2007-12-25 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
US7842727B2 (en) * | 2001-03-27 | 2010-11-30 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
US8026280B2 (en) * | 2001-03-27 | 2011-09-27 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
US20030212191A1 (en) * | 2002-04-15 | 2003-11-13 | Nippon Bee Chemical Co., Ltd. | Aqueous primer coating composition, process for formation of coating film using said composition, and coated article |
WO2003099272A1 (en) * | 2002-05-22 | 2003-12-04 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors based on alpha-ketoepoxide compounds |
AU2003291097A1 (en) * | 2002-11-20 | 2004-06-15 | Errant Gene Therapeutics, Llc | Treatment of lung cells with histone deacetylase inhibitors |
JP5289707B2 (ja) * | 2004-08-31 | 2013-09-11 | 住友ベークライト株式会社 | オキシルアミノ基含有化合物 |
US20060160902A1 (en) * | 2004-11-08 | 2006-07-20 | Wiech Norbert L | Histone deacetylase inhibitors |
US7754838B2 (en) * | 2006-08-08 | 2010-07-13 | E.I. Du Pont De Nemours And Company | Poly(meth)acrylamides and poly(meth)acrylates containing fluorinated amide |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3177227A (en) * | 1963-01-30 | 1965-04-06 | Shell Oil Co | Lactone production |
DE2945497A1 (de) * | 1979-03-06 | 1980-10-09 | Degussa | Derivate der d-2-hydroxy-4-methylmercaptobuttersaeure, verfahren zu deren herstellung und deren verwendung |
US4311645A (en) * | 1980-03-24 | 1982-01-19 | Hoffmann-La Roche Inc. | Synthesis of SRS-active compounds |
FR2479213A1 (fr) * | 1980-03-28 | 1981-10-02 | Roussel Uclaf | Procede de preparation d'acide pentenoique possedant une fonction aldehyde |
JPS57118555A (en) * | 1981-01-13 | 1982-07-23 | Ono Pharmaceut Co Ltd | Leucotriene-analog compound, its preparation, and leucotriene-biosynthesis inhibiting agent containing said compound as active component |
US4352757A (en) * | 1981-02-02 | 1982-10-05 | Smithkline Beckman Corporation | Process for the preparation of esters of leukotriene A |
-
1982
- 1982-06-09 US US06/386,570 patent/US4513005A/en not_active Expired - Fee Related
- 1982-06-14 IL IL66056A patent/IL66056A0/xx not_active IP Right Cessation
- 1982-06-16 PT PT75058A patent/PT75058B/pt not_active IP Right Cessation
- 1982-06-16 NZ NZ200984A patent/NZ200984A/en unknown
- 1982-06-16 PH PH27436A patent/PH23051A/en unknown
- 1982-06-16 DK DK271682A patent/DK271682A/da not_active Application Discontinuation
- 1982-06-16 HU HU821941A patent/HU192105B/hu not_active IP Right Cessation
- 1982-06-17 CA CA000405382A patent/CA1224795A/en not_active Expired
- 1982-06-17 ZA ZA824294A patent/ZA824294B/xx unknown
- 1982-06-17 ES ES513221A patent/ES8307212A1/es not_active Expired
- 1982-06-17 DD DD82240838A patent/DD202697A5/de not_active IP Right Cessation
- 1982-06-17 EP EP82303154A patent/EP0068739B1/en not_active Expired
- 1982-06-17 RO RO107910A patent/RO83706B/ro unknown
- 1982-06-17 GB GB08217589A patent/GB2101594B/en not_active Expired
- 1982-06-17 DE DE8282303154T patent/DE3261237D1/de not_active Expired
- 1982-06-17 BG BG8257037A patent/BG37226A3/xx unknown
- 1982-06-17 IE IE1443/82A patent/IE53522B1/en not_active IP Right Cessation
- 1982-06-18 PL PL1982240482A patent/PL137766B1/pl unknown
- 1982-06-18 AU AU85008/82A patent/AU549814B2/en not_active Ceased
- 1982-06-18 PL PL23699282A patent/PL236992A1/xx unknown
- 1982-06-18 PL PL24048482A patent/PL240484A1/xx unknown
- 1982-06-18 FI FI822205A patent/FI77847C/fi not_active IP Right Cessation
- 1982-06-18 KR KR828202722A patent/KR890000622B1/ko active
- 1982-06-18 CS CS824565A patent/CS241109B2/cs unknown
- 1982-06-18 GR GR68479A patent/GR76838B/el unknown
- 1982-06-18 PL PL24048382A patent/PL240483A1/xx unknown
-
1983
- 1983-03-16 ES ES520670A patent/ES8404307A1/es not_active Expired
- 1983-03-16 ES ES520671A patent/ES8404322A1/es not_active Expired
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Legal Events
Date | Code | Title | Description |
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FD1A | Patent lapsed |
Effective date: 19970203 |