ES8502129A1 - Un procedimiento para la preparacion de compuestos de acidos biliares - Google Patents

Un procedimiento para la preparacion de compuestos de acidos biliares

Info

Publication number
ES8502129A1
ES8502129A1 ES524491A ES524491A ES8502129A1 ES 8502129 A1 ES8502129 A1 ES 8502129A1 ES 524491 A ES524491 A ES 524491A ES 524491 A ES524491 A ES 524491A ES 8502129 A1 ES8502129 A1 ES 8502129A1
Authority
ES
Spain
Prior art keywords
production
pharmaceutical compositions
same
compositions containing
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524491A
Other languages
English (en)
Other versions
ES524491A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lehner AG
Original Assignee
Lehner AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT22632/82A external-priority patent/IT1190931B/it
Priority claimed from IT21909/83A external-priority patent/IT1194297B/it
Application filed by Lehner AG filed Critical Lehner AG
Publication of ES8502129A1 publication Critical patent/ES8502129A1/es
Publication of ES524491A0 publication Critical patent/ES524491A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUETOS DE ACIDOS BILIARES.CONSISTE EN SOMETER A HIDROLISIS, EN UN MEDIO BASICO (SOLUCION DE HIDROXIDO SODICO O POTASICO), A UNA TEMPERATURA COMPRENDIDA ENTRE 20 Y 100JC Y DURANTE UN TIEMPO DE 1 A 12 H, UN COMPUESTO DE FORMULA (II) PARA OBTENER UN COMPUESTO DE FORMULA (I), SIENDO ST UN RESTO 17-ETIOCOLANILO, CON DOS O MAS GRUPOS HIDROXILO (OPCIONALMENTE SUSTITUIDOS POR GRUPOS CETO); ST UN RESTO ETIOCOLANILO CON DOS O MAS GRUPOS ACILOXI (OPCIONALMENTE SUSTITUIDOS POR GRUPOS CETO) Y R UN RESTO ALQUILO CON C 1 A 4.SE UTILIZA EN LA FABRICACION DE PRODUCTOS FARMACEUTICOS.
ES524491A 1982-07-29 1983-07-28 Un procedimiento para la preparacion de compuestos de acidos biliares Granted ES524491A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22632/82A IT1190931B (it) 1982-07-29 1982-07-29 Derivati di acidi biliari,procedimento per la loro preparazione e relative composizioni farmaceutiche
IT21909/83A IT1194297B (it) 1983-07-01 1983-07-01 Derivati di acidi biliari,procedimento per la loro preparazione e relative composizioni farmaceutiche

Publications (2)

Publication Number Publication Date
ES8502129A1 true ES8502129A1 (es) 1984-12-16
ES524491A0 ES524491A0 (es) 1984-12-16

Family

ID=26328036

Family Applications (1)

Application Number Title Priority Date Filing Date
ES524491A Granted ES524491A0 (es) 1982-07-29 1983-07-28 Un procedimiento para la preparacion de compuestos de acidos biliares

Country Status (4)

Country Link
US (1) US4514393A (es)
EP (1) EP0101554B1 (es)
DE (1) DE3366932D1 (es)
ES (1) ES524491A0 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1206112B (it) * 1983-04-29 1989-04-14 Lehner Ag Nuovi derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche.
IT1212835B (it) * 1983-08-18 1989-11-30 Lehner Ag Derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche.
US4892868A (en) * 1984-08-17 1990-01-09 Gipharmex, S.P.A. Derivatives of biliary acids, process for the production thereof and corresponding pharmaceutical compositions
IT1196377B (it) * 1984-12-21 1988-11-16 Lehner Ag Derivati di acidi biliari,procedimento per la loro preparazione e relative composizioni farmaceutiche
JP3546886B2 (ja) * 1993-03-10 2004-07-28 ジェネーラ コーポレーション ステロイド誘導体、それらを含む薬剤組成物、及び抗生物質又は消毒薬としてのそれらの使用
US5840740A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds and a method of treating infection using the aminosterol compounds
US5856535A (en) * 1994-08-18 1999-01-05 Magainin Pharmaceuticals, Inc. Aminosterol ester compounds
US5847172A (en) * 1995-06-07 1998-12-08 Magainin Pharmaceuticals Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US6143738A (en) * 1995-06-07 2000-11-07 Magainin Pharmaceuticals, Inc. Therapeutic uses for an aminosterol compound
US5795885A (en) * 1995-06-07 1998-08-18 Magainin Pharmaceuticals Inc. Method of inhibiting profileration of cells by administering an aminosterol compound
US5792635A (en) * 1995-06-07 1998-08-11 Magainin Pharmaceuticals, Inc. Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
US5840936A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE)
US5994336A (en) * 1995-06-07 1999-11-30 Magainin Pharmaceuticals Inc. Method of inhibiting proliferation of cells by administering an aminosterol compound
US5763430A (en) * 1995-06-07 1998-06-09 Magainin Pharmaceuticals Inc. Method of treating a viral infection by administering a steroid compound
US5874597A (en) * 1995-06-07 1999-02-23 Magainin Pharmaceuticals, Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US6596712B2 (en) 1996-04-26 2003-07-22 Genaera Corporation Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities
JP2000510460A (ja) * 1996-04-26 2000-08-15 マゲイニン・ファーマシューティカルズ・インコーポレーテッド スクアラミンを他の抗癌剤と併用する上皮性悪性腫瘍の治療
US6262283B1 (en) 1996-12-06 2001-07-17 Magainin Pharmaceuticals Inc. Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds
AU5342701A (en) * 2000-04-12 2001-10-30 Genaera Corp A process for the preparation of 7.alpha.-hydroxy 3-aminosubstituted sterols using intermediates with an unprotected 7.alpha.-hydroxy group
DK1392714T3 (da) 2001-03-12 2006-01-09 Intercept Pharmaceuticals Inc Steroider som agonister for FXR
EP2712617B2 (en) 2004-03-12 2020-11-18 Intercept Pharmaceuticals, Inc. Treatment of fibrosis using Fxr ligands
US10987362B2 (en) 2004-03-12 2021-04-27 Intercept Pharmaceuticals, Inc. Treatment of fibrosis using FXR ligands
ITMI20050912A1 (it) 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
JP5292310B2 (ja) 2007-01-19 2013-09-18 インターセプト ファーマシューティカルズ， インコーポレイテッド Ｔｇｒ５調節剤としての２３−置換胆汁酸およびその使用方法
EP1947108A1 (en) * 2007-01-19 2008-07-23 Intercept Pharmaceuticals, Inc. TGR5 modulators and methods of use thereof
CN105037476B (zh) 2008-07-30 2018-06-12 英特塞普特医药品公司 Tgr5调节剂及其使用方法
HUE039171T2 (hu) 2008-11-19 2018-12-28 Intercept Pharmaceuticals Inc TGR5 modulátorok és azok alkalmazási eljárása
CA3028207A1 (en) 2012-06-19 2013-12-27 Intercept Pharmaceuticals, Inc. Preparation, uses and solid forms of obeticholic acid
US9982008B2 (en) 2012-06-19 2018-05-29 Intercept Pharmaceuticals, Inc. Preparation and uses of obeticholic acid
DE102014010259A1 (de) 2014-07-11 2016-01-14 Metten Stein + Design Gmbh & Co. Kg Verfahren zum Herstellen von Betonelementen
IL258359B2 (en) * 2015-10-07 2023-11-01 Intercept Pharmaceuticals Inc Paranoid X receptor modulators.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4354972A (en) * 1981-06-29 1982-10-19 Kaiser Emil T Synthesis of steroids

Also Published As

Publication number Publication date
US4514393A (en) 1985-04-30
DE3366932D1 (en) 1986-11-20
EP0101554A3 (en) 1984-07-25
ES524491A0 (es) 1984-12-16
EP0101554B1 (en) 1986-10-15
EP0101554A2 (en) 1984-02-29

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