DE3366932D1 - New derivatives of biliary acids, process for the production thereof and pharmaceutical compositions containing the same - Google Patents

New derivatives of biliary acids, process for the production thereof and pharmaceutical compositions containing the same

Info

Publication number
DE3366932D1
DE3366932D1 DE8383106708T DE3366932T DE3366932D1 DE 3366932 D1 DE3366932 D1 DE 3366932D1 DE 8383106708 T DE8383106708 T DE 8383106708T DE 3366932 T DE3366932 T DE 3366932T DE 3366932 D1 DE3366932 D1 DE 3366932D1
Authority
DE
Germany
Prior art keywords
production
pharmaceutical compositions
same
compositions containing
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383106708T
Other languages
English (en)
Inventor
Virginio Castagnola
E Giuliano Frigerio
Roberto Pellicciari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lehner AG
Original Assignee
Lehner AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT22632/82A external-priority patent/IT1190931B/it
Priority claimed from IT21909/83A external-priority patent/IT1194297B/it
Application filed by Lehner AG filed Critical Lehner AG
Application granted granted Critical
Publication of DE3366932D1 publication Critical patent/DE3366932D1/de
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J9/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
DE8383106708T 1982-07-29 1983-07-08 New derivatives of biliary acids, process for the production thereof and pharmaceutical compositions containing the same Expired DE3366932D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22632/82A IT1190931B (it) 1982-07-29 1982-07-29 Derivati di acidi biliari,procedimento per la loro preparazione e relative composizioni farmaceutiche
IT21909/83A IT1194297B (it) 1983-07-01 1983-07-01 Derivati di acidi biliari,procedimento per la loro preparazione e relative composizioni farmaceutiche

Publications (1)

Publication Number Publication Date
DE3366932D1 true DE3366932D1 (en) 1986-11-20

Family

ID=26328036

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383106708T Expired DE3366932D1 (en) 1982-07-29 1983-07-08 New derivatives of biliary acids, process for the production thereof and pharmaceutical compositions containing the same

Country Status (4)

Country Link
US (1) US4514393A (de)
EP (1) EP0101554B1 (de)
DE (1) DE3366932D1 (de)
ES (1) ES8502129A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1206112B (it) * 1983-04-29 1989-04-14 Lehner Ag Nuovi derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche.
IT1212835B (it) * 1983-08-18 1989-11-30 Lehner Ag Derivati di acidi biliari, procedimento per la loro preparazione e relative composizioni farmaceutiche.
US4892868A (en) * 1984-08-17 1990-01-09 Gipharmex, S.P.A. Derivatives of biliary acids, process for the production thereof and corresponding pharmaceutical compositions
IT1196377B (it) * 1984-12-21 1988-11-16 Lehner Ag Derivati di acidi biliari,procedimento per la loro preparazione e relative composizioni farmaceutiche
ES2123133T3 (es) * 1993-03-10 1999-01-01 Magainin Pharma Derivados esteroidianos, composiciones farmaceuticas que contienen estos derivados esteroidianos y utilizacion de estos ultimos como antibioticos o desinfectantes.
US5856535A (en) * 1994-08-18 1999-01-05 Magainin Pharmaceuticals, Inc. Aminosterol ester compounds
US5840740A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds and a method of treating infection using the aminosterol compounds
US5763430A (en) * 1995-06-07 1998-06-09 Magainin Pharmaceuticals Inc. Method of treating a viral infection by administering a steroid compound
US5847172A (en) * 1995-06-07 1998-12-08 Magainin Pharmaceuticals Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5874597A (en) * 1995-06-07 1999-02-23 Magainin Pharmaceuticals, Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US5840936A (en) * 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE)
US5795885A (en) * 1995-06-07 1998-08-18 Magainin Pharmaceuticals Inc. Method of inhibiting profileration of cells by administering an aminosterol compound
US6143738A (en) * 1995-06-07 2000-11-07 Magainin Pharmaceuticals, Inc. Therapeutic uses for an aminosterol compound
US5994336A (en) * 1995-06-07 1999-11-30 Magainin Pharmaceuticals Inc. Method of inhibiting proliferation of cells by administering an aminosterol compound
US5792635A (en) * 1995-06-07 1998-08-11 Magainin Pharmaceuticals, Inc. Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
CA2252584C (en) * 1996-04-26 2008-06-10 Magainin Pharmaceuticals Inc. Treatment of carcinomas using squalamine in combination with other anti-cancer agents
US6596712B2 (en) 1996-04-26 2003-07-22 Genaera Corporation Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities
US6262283B1 (en) 1996-12-06 2001-07-17 Magainin Pharmaceuticals Inc. Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds
CA2406847C (en) * 2000-04-12 2009-11-17 Genaera Corporation Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols
IL157816A0 (en) 2001-03-12 2004-03-28 Roberto Pellicciari Steroids as agonists for fxr
US10987362B2 (en) 2004-03-12 2021-04-27 Intercept Pharmaceuticals, Inc. Treatment of fibrosis using FXR ligands
EP2712617B2 (de) 2004-03-12 2020-11-18 Intercept Pharmaceuticals, Inc. Behandlung Von Fibrose Mit Fxr-Liganden
ITMI20050912A1 (it) 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
EP1947108A1 (de) * 2007-01-19 2008-07-23 Intercept Pharmaceuticals, Inc. TGR5-Modulatoren und Anwendungsverfahren dafür
CA2928178C (en) * 2007-01-19 2019-09-10 Intercept Pharmaceuticals, Inc. Tgr5 modulators and methods of use thereof
US8796249B2 (en) 2008-07-30 2014-08-05 Intercept Pharmaceuticals, Inc. TGR5 modulators and methods of use thereof
PT2698375T (pt) 2008-11-19 2018-05-25 Intercept Pharmaceuticals Inc Moduladores de tgr5 e método de utilização dos mesmos
US9982008B2 (en) 2012-06-19 2018-05-29 Intercept Pharmaceuticals, Inc. Preparation and uses of obeticholic acid
SI3336097T1 (sl) 2012-06-19 2021-07-30 Intercept Pharmaceuticals, Inc. Priprava nekristalinične oblike obetiholne kisline
DE102014010259A1 (de) 2014-07-11 2016-01-14 Metten Stein + Design Gmbh & Co. Kg Verfahren zum Herstellen von Betonelementen
CR20180201A (es) * 2015-10-07 2018-08-24 Intercept Pharmaceuticals Inc Modularores del receptor x farnesoide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4354972A (en) * 1981-06-29 1982-10-19 Kaiser Emil T Synthesis of steroids

Also Published As

Publication number Publication date
EP0101554A3 (en) 1984-07-25
US4514393A (en) 1985-04-30
ES524491A0 (es) 1984-12-16
EP0101554B1 (de) 1986-10-15
ES8502129A1 (es) 1984-12-16
EP0101554A2 (de) 1984-02-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee