ES8302002A1 - Un procedimiento para la preparacion de nuevos derivados de cefalosporina. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de cefalosporina.

Info

Publication number
ES8302002A1
ES8302002A1 ES505923A ES505923A ES8302002A1 ES 8302002 A1 ES8302002 A1 ES 8302002A1 ES 505923 A ES505923 A ES 505923A ES 505923 A ES505923 A ES 505923A ES 8302002 A1 ES8302002 A1 ES 8302002A1
Authority
ES
Spain
Prior art keywords
preparation
compositions containing
cephalosporin derivatives
groups
group selected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505923A
Other languages
English (en)
Other versions
ES505923A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP55136449A external-priority patent/JPS5759894A/ja
Priority claimed from JP5523181A external-priority patent/JPS57169489A/ja
Priority claimed from JP8911681A external-priority patent/JPS57206687A/ja
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of ES8302002A1 publication Critical patent/ES8302002A1/es
Publication of ES505923A0 publication Critical patent/ES505923A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE CEFALOSPORINA Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R ES METILO O ETILO; R ES HIDROGENO O METILO; Y R ES ALQUILO C <003> O ALCOXI C <003> . CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) O UN DERIVADO REACTIVO DEL MISMO CON UN COMPUESTO DE FORMULA R <024>COOCHR B, EN LAS QUE A ES OXIGENO O =NOR ; R ES AMINO O AMINO PROTEGIDO; R ES HIDROXI Y B ES EL GRUPO DE FORMULA (III) O R ES EL GRUPO DE FORMULA (IV) Y B ES HALOGENO; Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE A LA TEMPERATURA AMBIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIBACTERIANA.
ES505923A 1980-09-30 1981-09-30 Un procedimiento para la preparacion de nuevos derivados de cefalosporina. Granted ES505923A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP55136449A JPS5759894A (en) 1980-09-30 1980-09-30 Cephalosporin for oral administration
JP5523181A JPS57169489A (en) 1981-04-13 1981-04-13 Cephalosporin derivative and its preparation
JP8911681A JPS57206687A (en) 1981-06-10 1981-06-10 Cephalosporin derivative and its preparation

Publications (2)

Publication Number Publication Date
ES8302002A1 true ES8302002A1 (es) 1982-12-16
ES505923A0 ES505923A0 (es) 1982-12-16

Family

ID=27295533

Family Applications (4)

Application Number Title Priority Date Filing Date
ES505923A Granted ES505923A0 (es) 1980-09-30 1981-09-30 Un procedimiento para la preparacion de nuevos derivados de cefalosporina.
ES514995A Expired ES8306759A1 (es) 1980-09-30 1982-08-13 Un procedimiento para la preparacion de nuevos derivados de cefalosporina.
ES514993A Expired ES8306158A1 (es) 1980-09-30 1982-08-13 Un procedimiento para la preparacion de nuevos derivados de cefalosporina.
ES514994A Granted ES514994A0 (es) 1980-09-30 1982-08-13 Un procedimiento para la preparacion de nuevos derivados de cefalosporina.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES514995A Expired ES8306759A1 (es) 1980-09-30 1982-08-13 Un procedimiento para la preparacion de nuevos derivados de cefalosporina.
ES514993A Expired ES8306158A1 (es) 1980-09-30 1982-08-13 Un procedimiento para la preparacion de nuevos derivados de cefalosporina.
ES514994A Granted ES514994A0 (es) 1980-09-30 1982-08-13 Un procedimiento para la preparacion de nuevos derivados de cefalosporina.

Country Status (11)

Country Link
US (2) US4486425A (es)
EP (1) EP0049118B1 (es)
KR (1) KR870000848B1 (es)
AU (1) AU547984B2 (es)
CA (1) CA1171404A (es)
DE (1) DE3174472D1 (es)
ES (4) ES505923A0 (es)
FI (1) FI73440C (es)
IE (1) IE53177B1 (es)
NL (1) NL930098I2 (es)
PH (1) PH18740A (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
US5223496A (en) * 1987-11-10 1993-06-29 The Upjohn Company Cephalosporin antibiotics
JPH01230547A (ja) * 1988-01-14 1989-09-14 Takeda Chem Ind Ltd ３−オキソ酪酸第三ブチルの製造法及びその用途
DE3804841A1 (de) * 1988-02-17 1989-08-31 Hoechst Ag Cephalosporinderivate und verfahren zu ihrer herstellung
GB8809534D0 (en) * 1988-04-22 1988-05-25 Beecham Group Plc Novel compounds
DE3901405A1 (de) * 1989-01-19 1990-07-26 Hoechst Ag Cephalosporinderivate und verfahren zu ihrer herstellung
DE3919259A1 (de) * 1989-06-13 1990-12-20 Hoechst Ag Kristalline cephem-saeureadditionssalze und verfahren zu ihrer herstellung
YU48484B (sh) * 1991-05-24 1998-09-18 Hoechst Aktiengesellschaft Kristalne kiselinske adicione soli diastereomerno čistih 1-(2,2-dimetilpropioniloksi)-etilestara 3-cefem-4-karbonske kiseline
PT531875E (pt) * 1991-09-07 2004-08-31 Aventis Pharma Gmbh Diastereomeros do ester 1-(isopropoxicarboniloxi)-etilico do acido 3-cefem-4-carboxilico e processo para a sua preparacao
TW212181B (es) * 1992-02-14 1993-09-01 Hoechst Ag
ES2117066T3 (es) * 1992-05-21 1998-08-01 Hoechst Ag Procedimiento para la disociacion de esteres profarmacos de cefalosporina para dar acido 7-amino-3-metoximetil-cef-3-em-4-carboxilico.
LT3870B (en) 1993-11-30 1996-04-25 Hoechst Ag Diastereomers of 3-cefem-4-carboxylic acid 1-(isopropoxy-carbonyloxy)ethyl ester, process for preparingthereof, antibacteric preparations based on same and process for preparation thereof
US5929086A (en) * 1996-05-10 1999-07-27 Pharmacia & Upjohn Company Topical administration of antimicrobial agents for the treatment of systemic bacterial diseases
AT413383B (de) 1998-01-09 2006-02-15 Sandoz Ag Verfahren zur isolierung eines diastereoisomerengemisches von cefpodoxim proxetil
AT408226B (de) 1999-05-05 2001-09-25 Biochemie Gmbh Kristalliner 7-(2-(2-formylaminothiazol-4-yl)-2
IN191496B (es) 1999-07-30 2003-12-06 Ranbaxy Lab Ltd
KR100342944B1 (ko) * 1999-11-08 2002-07-02 민경윤 고순도 세프포독심 프록세틸의 제조방법
WO2002068429A1 (en) * 2001-02-27 2002-09-06 Ranbaxy Laboratories Limited Process for the preparation of cefpodoxime proxetil
JP2004522782A (ja) * 2001-02-27 2004-07-29 ランバクシー ラボラトリーズ リミテッド セフポドキシムプロキセチルの経口薬剤組成物
EP1490090A4 (en) 2002-02-22 2006-09-20 New River Pharmaceuticals Inc SYSTEMS FOR DELIVERING ACTIVE AGENTS AND METHODS FOR PROTECTING AND DELIVERING ACTIVE AGENTS
WO2004048387A1 (en) * 2002-11-22 2004-06-10 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of cefpodoxime proxetil
AU2002368494A1 (en) * 2002-12-20 2004-07-14 Lupin Limited A process for the preparation of cefpodoxime proxetil
GB0301938D0 (en) * 2003-01-28 2003-02-26 Biochemie Gmbh Organic compounds
US20040242863A1 (en) * 2003-05-27 2004-12-02 Carenini Alessandro Riccardo Preparation of cefalosporins intermediates and conversion of said intermediates into active compound precursors
WO2010097675A1 (en) 2009-02-27 2010-09-02 Dhanuka Laboratories Ltd. An improved preparation process for cefpodoxime proxetil
TR201002878A2 (tr) 2010-04-13 2011-10-21 Bi̇lgi̇ç Mahmut Sefpodoksim proksetil içeren farmasötik bileşimler.
EP2575777A1 (en) 2010-06-03 2013-04-10 Mahmut Bilgic Formulation comprising cefpodoxime proxetil and clavulanic acid
EP2575812A2 (en) 2010-06-03 2013-04-10 Mahmut Bilgic Pharmaceutical composition comprising cefpodoxime proxetil and clavulanic acid
TR201007107A1 (tr) 2010-08-25 2012-03-21 B�Lg�� Mahmut Tat düzenleyici ajan içeren sefpodoksim proksetil formülasyonları.
TR201007106A1 (tr) 2010-08-25 2012-03-21 Bi̇lgi̇ç Mahmut Sefpodoksim proksetil formülasyonları.
TR201009168A2 (tr) 2010-11-05 2012-05-21 Bi̇lgi̇ç Mahmut Suda dağılan sefpodoksim proksetil formülasyonları.
EP2520578A1 (en) 2011-05-06 2012-11-07 Lupin Limited Process for purification of cephalosporins
EP2758407A1 (en) 2011-09-20 2014-07-30 Dhanuka Laboratories Ltd. An improved process for cefpodoxime acid
EP2833872A1 (en) 2012-04-04 2015-02-11 Mahmut Bilgic Tablet formulations comprising cefpodoxime proxetil and clavulanic acid
WO2014123500A1 (en) 2013-02-11 2014-08-14 Bilgiç Mahmut Pharmaceutical formulations comprising cefpodoxime proxetil and clavulanic acid

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024137A (en) * 1971-05-14 1977-05-17 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(phenyl- or naphthylacetamido)] cephalosporins
GB1425933A (en) * 1972-03-13 1976-02-25 Astra Laekemedel Ab Cephalosporins
JPS5119765A (en) * 1974-08-09 1976-02-17 Takeda Chemical Industries Ltd Aminochiazoorujudotaino seizoho
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
GR63088B (en) * 1976-04-14 1979-08-09 Takeda Chemical Industries Ltd Preparation process of novel cephalosporins
JPS53103493A (en) * 1977-02-18 1978-09-08 Takeda Chem Ind Ltd Cephalosporin derivatives and process for their preparation
DE2714880A1 (de) 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
US4409215A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof
FR2476087A1 (fr) * 1980-02-18 1981-08-21 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments

Also Published As

Publication number Publication date
EP0049118A3 (en) 1983-01-19
ES514995A0 (es) 1983-06-01
DE3174472D1 (en) 1986-05-28
IE53177B1 (en) 1988-08-17
NL930098I1 (nl) 1993-10-01
FI813038L (fi) 1982-03-31
IE812273L (en) 1982-03-30
ES8306759A1 (es) 1983-06-01
US4486425A (en) 1984-12-04
NL930098I2 (nl) 1995-02-01
EP0049118B1 (en) 1986-04-23
AU7578181A (en) 1982-04-08
KR870000848B1 (ko) 1987-04-25
ES514993A0 (es) 1983-05-01
PH18740A (en) 1985-09-16
AU547984B2 (en) 1985-11-14
ES8306158A1 (es) 1983-05-01
ES505923A0 (es) 1982-12-16
FI73440B (fi) 1987-06-30
CA1171404A (en) 1984-07-24
ES8306159A1 (es) 1983-05-01
ES514994A0 (es) 1983-05-01
KR830007685A (ko) 1983-11-04
EP0049118A2 (en) 1982-04-07
FI73440C (fi) 1987-10-09
US4716158A (en) 1987-12-29

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