ES8301989A1 - Procedimiento para la obtencion de amidinas de acido carbo- xilico n,n'-puenteadas - Google Patents
Procedimiento para la obtencion de amidinas de acido carbo- xilico n,n'-puenteadasInfo
- Publication number
- ES8301989A1 ES8301989A1 ES499973A ES499973A ES8301989A1 ES 8301989 A1 ES8301989 A1 ES 8301989A1 ES 499973 A ES499973 A ES 499973A ES 499973 A ES499973 A ES 499973A ES 8301989 A1 ES8301989 A1 ES 8301989A1
- Authority
- ES
- Spain
- Prior art keywords
- amidines
- pharmaceutical preparations
- production
- preparations containing
- represents optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Gasification And Melting Of Waste (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Dental Preparations (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Carbon And Carbon Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE AMIDINAS DE ACIDO CARBOXILICO N,N''-PUENTEADAS Y DE SUS SALES, DE FORMULA (I), EN LA QUE R ES UN RADICAL AROMATICO; R ES 1-CARBOXIALQUILO INFERIOR, ESTERIFICADO O AMIDADO; PH ES 1,2-FENILENO; Y ALK ES VINILENO. CONSISTE EN LA REACCION DE DESHIDROGENACION BAJO DISOCIACION DE HIDROGENO, DE UN COMPUESTO DE FORMULA (II), EN LA QUE ALK'' ES ETILENO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), CON FORMACION SIMULTANEA DE UN ENLACE ADICIONAL. LA REACCION SE REALIZA EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN AGENTE DE DESHIDROGENACION, A UNA TEMPERATURA ENTRE 100<025>C Y 300<025>C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS EFECTOS ANTINOCICEPTIVO, ANTIINFLAMATORIO Y ANTIARTRITICO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH170380 | 1980-03-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8301989A1 true ES8301989A1 (es) | 1983-01-16 |
| ES499973A0 ES499973A0 (es) | 1983-01-16 |
Family
ID=4216625
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES499973A Granted ES499973A0 (es) | 1980-03-04 | 1981-03-02 | Procedimiento para la obtencion de amidinas de acido carbo- xilico n,n'-puenteadas |
| ES509645A Granted ES509645A0 (es) | 1980-03-04 | 1982-02-16 | Procedimiento para la obtencion de amidinas de acido carboxilico n,n'-puenteadas. |
| ES514590A Expired ES8305763A1 (es) | 1980-03-04 | 1982-07-30 | Procedimiento para la obtencion de amidinas de acido carboxilico n,n'-puenteadas. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES509645A Granted ES509645A0 (es) | 1980-03-04 | 1982-02-16 | Procedimiento para la obtencion de amidinas de acido carboxilico n,n'-puenteadas. |
| ES514590A Expired ES8305763A1 (es) | 1980-03-04 | 1982-07-30 | Procedimiento para la obtencion de amidinas de acido carboxilico n,n'-puenteadas. |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0035474B1 (es) |
| JP (1) | JPS56138188A (es) |
| KR (5) | KR850000045B1 (es) |
| AT (1) | ATE13673T1 (es) |
| AU (1) | AU544236B2 (es) |
| CA (1) | CA1161433A (es) |
| CY (1) | CY1340A (es) |
| DD (1) | DD156599A5 (es) |
| DE (1) | DE3170801D1 (es) |
| DK (1) | DK157757C (es) |
| ES (3) | ES499973A0 (es) |
| FI (1) | FI74007C (es) |
| GB (1) | GB2070608B (es) |
| GR (1) | GR74470B (es) |
| HK (1) | HK80086A (es) |
| HU (1) | HU186385B (es) |
| IE (1) | IE50985B1 (es) |
| IL (1) | IL62249A (es) |
| KE (1) | KE3646A (es) |
| MY (1) | MY8600361A (es) |
| NO (1) | NO156012C (es) |
| NZ (1) | NZ196393A (es) |
| PT (1) | PT72597B (es) |
| ZA (1) | ZA811398B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444768A (en) * | 1980-03-04 | 1984-04-24 | Ciba-Geigy Corporation | Pyrimido[1,6-a]indoles, pharmaceutical preparations containing them, and methods of treating pain and inflammation with them |
| ATE19083T1 (de) * | 1981-08-03 | 1986-04-15 | Ciba Geigy Ag | Weitere neue amidine, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische praeparate und ihre verwendung. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4307234A (en) * | 1978-09-11 | 1981-12-22 | American Home Products Corp. | Pyrimido[1,6-a]indole derivatives |
-
1981
- 1981-02-26 DE DE8181810064T patent/DE3170801D1/de not_active Expired
- 1981-02-26 EP EP81810064A patent/EP0035474B1/de not_active Expired
- 1981-02-26 AT AT81810064T patent/ATE13673T1/de active
- 1981-02-27 DD DD81227945A patent/DD156599A5/de not_active IP Right Cessation
- 1981-03-02 CA CA000372095A patent/CA1161433A/en not_active Expired
- 1981-03-02 GR GR64268A patent/GR74470B/el unknown
- 1981-03-02 PT PT198172597A patent/PT72597B/pt unknown
- 1981-03-02 ES ES499973A patent/ES499973A0/es active Granted
- 1981-03-02 IL IL62249A patent/IL62249A/xx unknown
- 1981-03-02 FI FI810647A patent/FI74007C/fi not_active IP Right Cessation
- 1981-03-03 DK DK095081A patent/DK157757C/da not_active IP Right Cessation
- 1981-03-03 ZA ZA00811398A patent/ZA811398B/xx unknown
- 1981-03-03 CY CY1340A patent/CY1340A/xx unknown
- 1981-03-03 NZ NZ96393A patent/NZ196393A/xx unknown
- 1981-03-03 AU AU68016/81A patent/AU544236B2/en not_active Ceased
- 1981-03-03 IE IE455/81A patent/IE50985B1/en not_active IP Right Cessation
- 1981-03-03 NO NO810719A patent/NO156012C/no unknown
- 1981-03-03 HU HU81531A patent/HU186385B/hu unknown
- 1981-03-04 KR KR1019810000711A patent/KR850000045B1/ko active
- 1981-03-04 JP JP3001481A patent/JPS56138188A/ja active Granted
- 1981-05-03 GB GB8106589A patent/GB2070608B/en not_active Expired
-
1982
- 1982-02-16 ES ES509645A patent/ES509645A0/es active Granted
- 1982-07-30 ES ES514590A patent/ES8305763A1/es not_active Expired
-
1984
- 1984-08-27 KR KR1019840005217A patent/KR850000062B1/ko not_active IP Right Cessation
- 1984-08-27 KR KR1019840005215A patent/KR850000060B1/ko not_active IP Right Cessation
- 1984-08-27 KR KR1019840005218A patent/KR850000044B1/ko not_active IP Right Cessation
- 1984-08-27 KR KR1019840005216A patent/KR850000061B1/ko not_active IP Right Cessation
-
1986
- 1986-06-11 KE KE3646A patent/KE3646A/xx unknown
- 1986-10-23 HK HK800/86A patent/HK80086A/xx unknown
- 1986-12-30 MY MY361/86A patent/MY8600361A/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19960603 |