ES8207169A1 - Un procedimiento para la preparacion de nuevos derivados de piperazinilquinazolina y de homopiperazinilquinazolina hi- pertensora con acticidad. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de piperazinilquinazolina y de homopiperazinilquinazolina hi- pertensora con acticidad.

Info

Publication number
ES8207169A1
ES8207169A1 ES499377A ES499377A ES8207169A1 ES 8207169 A1 ES8207169 A1 ES 8207169A1 ES 499377 A ES499377 A ES 499377A ES 499377 A ES499377 A ES 499377A ES 8207169 A1 ES8207169 A1 ES 8207169A1
Authority
ES
Spain
Prior art keywords
piperazinylquinazoline
derivatives
dimethoxy
amino
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES499377A
Other languages
English (en)
Spanish (es)
Other versions
ES499377A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1677580A external-priority patent/JPS56113770A/ja
Priority claimed from JP5275480A external-priority patent/JPS56150072A/ja
Priority claimed from JP9610780A external-priority patent/JPS5721385A/ja
Priority claimed from JP9610680A external-priority patent/JPS5721384A/ja
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of ES499377A0 publication Critical patent/ES499377A0/es
Publication of ES8207169A1 publication Critical patent/ES8207169A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES499377A 1980-02-13 1981-02-12 Un procedimiento para la preparacion de nuevos derivados de piperazinilquinazolina y de homopiperazinilquinazolina hi- pertensora con acticidad. Expired ES8207169A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP1677580A JPS56113770A (en) 1980-02-13 1980-02-13 Novel quinazoline derivative and its preparation
JP5275480A JPS56150072A (en) 1980-04-21 1980-04-21 Novel quinazoline derivative and its preparation
JP9610780A JPS5721385A (en) 1980-07-14 1980-07-14 Novel aminoquinazoline derivative and its preparation
JP9610680A JPS5721384A (en) 1980-07-14 1980-07-14 Novel aminoquinazoline derivative and its preparation

Publications (2)

Publication Number Publication Date
ES499377A0 ES499377A0 (es) 1982-09-01
ES8207169A1 true ES8207169A1 (es) 1982-09-01

Family

ID=27456647

Family Applications (1)

Application Number Title Priority Date Filing Date
ES499377A Expired ES8207169A1 (es) 1980-02-13 1981-02-12 Un procedimiento para la preparacion de nuevos derivados de piperazinilquinazolina y de homopiperazinilquinazolina hi- pertensora con acticidad.

Country Status (9)

Country Link
US (1) US4426382A (Direct)
CA (1) CA1154765A (Direct)
CH (1) CH644857A5 (Direct)
DE (1) DE3105330A1 (Direct)
ES (1) ES8207169A1 (Direct)
FR (1) FR2475548A1 (Direct)
GB (1) GB2068961B (Direct)
IT (1) IT1172225B (Direct)
NL (1) NL191208C (Direct)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS236097B1 (en) * 1983-06-01 1985-05-15 Jan Koenig Acylderivatives of 2-piperazinochinazoline and method of their preparation
DE3346675A1 (de) * 1983-12-23 1985-07-04 Beiersdorf Ag, 2000 Hamburg Substituierte 1-(4-amino-6,7-dialkoxy-chinazolinyl)-4- cyclohexenyl-derivate des piperazins und homopiperazins, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen und zwischenprodukte
JPH0647540B2 (ja) * 1985-07-16 1994-06-22 エーザイ株式会社 虚血性心疾患・不整脈治療・予防剤
IT1270993B (it) * 1994-03-18 1997-05-26 Recordati Chem Pharm Derivati chinzolilamminici attivi come alfa-antagonisti
TWI350168B (en) * 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
JP2009531447A (ja) * 2006-03-29 2009-09-03 メルク エンド カムパニー インコーポレーテッド ジアゼパンオレキシン受容体アンタゴニスト
PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
US8653262B2 (en) 2007-05-31 2014-02-18 Boehringer Ingelheim International Gmbh CCR2 receptor antagonists and uses thereof
US20090325964A1 (en) * 2008-05-23 2009-12-31 Wyeth Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression
CN103724328B (zh) 2008-12-19 2015-10-14 贝林格尔.英格海姆国际有限公司 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺
EP2813503B1 (en) 2009-12-17 2016-04-20 Centrexion Therapeutics Corporation A process for the production of new CCR2 receptor antagonists and intermediates thereof
EP2569295B1 (en) 2010-05-12 2014-11-19 Boehringer Ingelheim International GmbH New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
US8877745B2 (en) 2010-05-12 2014-11-04 Boehringer Ingelheim International Gmbh CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
JP5647339B2 (ja) 2010-05-17 2014-12-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２アンタゴニスト及びこれらの使用
JP5636094B2 (ja) 2010-05-25 2014-12-03 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２受容体アンタゴニスト
WO2011151251A1 (en) 2010-06-01 2011-12-08 Boehringer Ingelheim International Gmbh New ccr2 antagonists
WO2013010839A1 (en) 2011-07-15 2013-01-24 Boehringer Ingelheim International Gmbh Novel and selective ccr2 antagonists
WO2013144180A1 (en) * 2012-03-28 2013-10-03 Intervet International B.V. Heteroaryl compounds with cyclic bridging unit for use in the treatment helminth infection
KR20150033652A (ko) 2012-06-20 2015-04-01 노파르티스 아게 보체 경로 조절제 및 그의 용도
WO2015095111A1 (en) 2013-12-18 2015-06-25 Merck Sharp & Dohme Corp. Diazepane orexin receptor antagonists
CN108026087B (zh) 2015-07-02 2021-06-04 中枢疗法公司 氨基嘧啶甲酮衍生物的柠檬酸盐
US11944624B2 (en) * 2017-07-06 2024-04-02 Case Western Reserve University Peptide and small molecule agonists of EphA and their uses

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3635979A (en) 1969-09-29 1972-01-18 Pfizer Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines
JPS536156B2 (Direct) * 1972-10-30 1978-03-04
US3935213A (en) 1973-12-05 1976-01-27 Pfizer Inc. Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives
US4001237A (en) * 1976-02-18 1977-01-04 Bristol-Myers Company Oxazole, isoxazole, thiazole and isothiazole amides
US4060615A (en) * 1976-02-18 1977-11-29 Mead Johnson & Company 2-Piperazinyl-6,7-dimethoxyquinazolines
US4189484A (en) * 1977-11-08 1980-02-19 Mitsubishi Yuka Pharmaceutical Co., Ltd. Antihypertensive quinazoline derivatives
US4287341A (en) 1979-11-01 1981-09-01 Pfizer Inc. Alkoxy-substituted-6-chloro-quinazoline-2,4-diones
JPS5728576A (en) * 1980-07-24 1982-02-16 Toshiba Corp Inverter device

Also Published As

Publication number Publication date
NL191208B (nl) 1994-10-17
NL8100726A (nl) 1981-09-16
CH644857A5 (de) 1984-08-31
IT8167213A0 (it) 1981-02-13
US4426382A (en) 1984-01-17
GB2068961B (en) 1983-11-30
GB2068961A (en) 1981-08-19
FR2475548A1 (fr) 1981-08-14
DE3105330C2 (Direct) 1991-07-25
ES499377A0 (es) 1982-09-01
IT1172225B (it) 1987-06-18
NL191208C (nl) 1995-03-16
FR2475548B1 (Direct) 1983-06-24
CA1154765A (en) 1983-10-04
DE3105330A1 (de) 1981-12-17

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612