JPS5721385A - Novel aminoquinazoline derivative and its preparation - Google Patents

Novel aminoquinazoline derivative and its preparation

Info

Publication number
JPS5721385A
JPS5721385A JP9610780A JP9610780A JPS5721385A JP S5721385 A JPS5721385 A JP S5721385A JP 9610780 A JP9610780 A JP 9610780A JP 9610780 A JP9610780 A JP 9610780A JP S5721385 A JPS5721385 A JP S5721385A
Authority
JP
Japan
Prior art keywords
formula
derivative
hypertension
novel
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP9610780A
Other languages
Japanese (ja)
Other versions
JPS6332788B2 (en
Inventor
Hironobu Sato
Hiroshi Fukumi
Hiroyuki Koike
Hiroshi Nishino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP9610780A priority Critical patent/JPS5721385A/en
Priority to GB8104185A priority patent/GB2068961B/en
Priority to US06/233,679 priority patent/US4426382A/en
Priority to CA000370761A priority patent/CA1154765A/en
Priority to ES499377A priority patent/ES8207169A1/en
Priority to CH94481A priority patent/CH644857A5/en
Priority to NL8100726A priority patent/NL191208C/en
Priority to FR8102821A priority patent/FR2475548A1/en
Priority to IT67213/81A priority patent/IT1172225B/en
Priority to DE19813105330 priority patent/DE3105330A1/en
Publication of JPS5721385A publication Critical patent/JPS5721385A/en
Publication of JPS6332788B2 publication Critical patent/JPS6332788B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:An aminoquinazoline derivative of formula I (m is an integer 1W 5; n is 2 or 3) and an acid addition salt thereof.
EXAMPLE: 4-Amino-2-[4-(cyclohexylideneacetyl)-1-piperazinyl]-6,7-dimethoxy dimethoxyquinazoline hydrochloride hydrate.
USE: Useful for the prevention and the remedy of various hypertensions, e.g. essential hypertension, renal hypertension and adrenal hypertension, and having hypotensive action.
PROCESS: A 2-halogenoquinazoline derivative of formula II (X is halogen) is condensed with a cyclic diamine derivative of formula III by the dehydrohalogenating reaction, to give the compound of formula I. The reaction proceeds smoothly by adding triethylamine, etc. as a deacidifying agent thereto.
COPYRIGHT: (C)1982,JPO&Japio
JP9610780A 1980-02-13 1980-07-14 Novel aminoquinazoline derivative and its preparation Granted JPS5721385A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP9610780A JPS5721385A (en) 1980-07-14 1980-07-14 Novel aminoquinazoline derivative and its preparation
GB8104185A GB2068961B (en) 1980-02-13 1981-02-11 Quinazoline derivatives
US06/233,679 US4426382A (en) 1980-02-13 1981-02-11 4-Amino-6,7-dimethoxy-2-piperazinylquinazoline derivatives, their preparation and use
CA000370761A CA1154765A (en) 1980-02-13 1981-02-12 4-amino-6, 7-dimethoxy-2-piperazinylquinazoline derivatives, their preparation and use
ES499377A ES8207169A1 (en) 1980-02-13 1981-02-12 4-Amino-6,7-dimethoxy-2-piperazinylquinazoline derivatives, their preparation and use
CH94481A CH644857A5 (en) 1980-02-13 1981-02-12 PIPERAZINYL CHINAZOLINE AND HOMOPIPERAZINYL CHINAZOLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING SUCH DERIVATIVES.
NL8100726A NL191208C (en) 1980-02-13 1981-02-13 4-Amino-6,7-dimethoxy-2- [4- (substituted carbonyl) -1-piperazinylquinazoline compounds having antihypertensive activity and pharmaceutical compositions containing these compounds.
FR8102821A FR2475548A1 (en) 1980-02-13 1981-02-13 NOVEL QUINAZOLINE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATION
IT67213/81A IT1172225B (en) 1980-02-13 1981-02-13 DERIVATIVES OF 4-AMINO-6,7-DIMETOXY-2-PIPERAZINYL-CHINAZOLINE, THEIR PREPARATION AND USE
DE19813105330 DE3105330A1 (en) 1980-02-13 1981-02-13 "4-AMINO-6,7-DIMETHOXY-2-PIPERAZINYL CHINAZOLINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE"

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9610780A JPS5721385A (en) 1980-07-14 1980-07-14 Novel aminoquinazoline derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS5721385A true JPS5721385A (en) 1982-02-04
JPS6332788B2 JPS6332788B2 (en) 1988-07-01

Family

ID=14156157

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9610780A Granted JPS5721385A (en) 1980-02-13 1980-07-14 Novel aminoquinazoline derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5721385A (en)

Also Published As

Publication number Publication date
JPS6332788B2 (en) 1988-07-01

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