JPS5721385A - Novel aminoquinazoline derivative and its preparation - Google Patents
Novel aminoquinazoline derivative and its preparationInfo
- Publication number
- JPS5721385A JPS5721385A JP9610780A JP9610780A JPS5721385A JP S5721385 A JPS5721385 A JP S5721385A JP 9610780 A JP9610780 A JP 9610780A JP 9610780 A JP9610780 A JP 9610780A JP S5721385 A JPS5721385 A JP S5721385A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- derivative
- hypertension
- novel
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:An aminoquinazoline derivative of formula I (m is an integer 1W 5; n is 2 or 3) and an acid addition salt thereof.
EXAMPLE: 4-Amino-2-[4-(cyclohexylideneacetyl)-1-piperazinyl]-6,7-dimethoxy dimethoxyquinazoline hydrochloride hydrate.
USE: Useful for the prevention and the remedy of various hypertensions, e.g. essential hypertension, renal hypertension and adrenal hypertension, and having hypotensive action.
PROCESS: A 2-halogenoquinazoline derivative of formula II (X is halogen) is condensed with a cyclic diamine derivative of formula III by the dehydrohalogenating reaction, to give the compound of formula I. The reaction proceeds smoothly by adding triethylamine, etc. as a deacidifying agent thereto.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9610780A JPS5721385A (en) | 1980-07-14 | 1980-07-14 | Novel aminoquinazoline derivative and its preparation |
GB8104185A GB2068961B (en) | 1980-02-13 | 1981-02-11 | Quinazoline derivatives |
US06/233,679 US4426382A (en) | 1980-02-13 | 1981-02-11 | 4-Amino-6,7-dimethoxy-2-piperazinylquinazoline derivatives, their preparation and use |
CA000370761A CA1154765A (en) | 1980-02-13 | 1981-02-12 | 4-amino-6, 7-dimethoxy-2-piperazinylquinazoline derivatives, their preparation and use |
ES499377A ES8207169A1 (en) | 1980-02-13 | 1981-02-12 | 4-Amino-6,7-dimethoxy-2-piperazinylquinazoline derivatives, their preparation and use |
CH94481A CH644857A5 (en) | 1980-02-13 | 1981-02-12 | PIPERAZINYL CHINAZOLINE AND HOMOPIPERAZINYL CHINAZOLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING SUCH DERIVATIVES. |
NL8100726A NL191208C (en) | 1980-02-13 | 1981-02-13 | 4-Amino-6,7-dimethoxy-2- [4- (substituted carbonyl) -1-piperazinylquinazoline compounds having antihypertensive activity and pharmaceutical compositions containing these compounds. |
FR8102821A FR2475548A1 (en) | 1980-02-13 | 1981-02-13 | NOVEL QUINAZOLINE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATION |
IT67213/81A IT1172225B (en) | 1980-02-13 | 1981-02-13 | DERIVATIVES OF 4-AMINO-6,7-DIMETOXY-2-PIPERAZINYL-CHINAZOLINE, THEIR PREPARATION AND USE |
DE19813105330 DE3105330A1 (en) | 1980-02-13 | 1981-02-13 | "4-AMINO-6,7-DIMETHOXY-2-PIPERAZINYL CHINAZOLINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE" |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9610780A JPS5721385A (en) | 1980-07-14 | 1980-07-14 | Novel aminoquinazoline derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5721385A true JPS5721385A (en) | 1982-02-04 |
JPS6332788B2 JPS6332788B2 (en) | 1988-07-01 |
Family
ID=14156157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9610780A Granted JPS5721385A (en) | 1980-02-13 | 1980-07-14 | Novel aminoquinazoline derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5721385A (en) |
-
1980
- 1980-07-14 JP JP9610780A patent/JPS5721385A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6332788B2 (en) | 1988-07-01 |
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