JPS56150072A - Novel quinazoline derivative and its preparation - Google Patents

Novel quinazoline derivative and its preparation

Info

Publication number
JPS56150072A
JPS56150072A JP5275480A JP5275480A JPS56150072A JP S56150072 A JPS56150072 A JP S56150072A JP 5275480 A JP5275480 A JP 5275480A JP 5275480 A JP5275480 A JP 5275480A JP S56150072 A JPS56150072 A JP S56150072A
Authority
JP
Japan
Prior art keywords
formula
quinazoline derivative
preparation
halogen
integer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5275480A
Other languages
Japanese (ja)
Other versions
JPS6140229B2 (en
Inventor
Hironobu Sato
Hiroshi Fukumi
Hiroyuki Koike
Hiroshi Nishino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP5275480A priority Critical patent/JPS56150072A/en
Priority to US06/233,679 priority patent/US4426382A/en
Priority to GB8104185A priority patent/GB2068961B/en
Priority to CA000370761A priority patent/CA1154765A/en
Priority to CH94481A priority patent/CH644857A5/en
Priority to ES499377A priority patent/ES8207169A1/en
Priority to DE19813105330 priority patent/DE3105330A1/en
Priority to IT67213/81A priority patent/IT1172225B/en
Priority to NL8100726A priority patent/NL191208C/en
Priority to FR8102821A priority patent/FR2475548A1/en
Publication of JPS56150072A publication Critical patent/JPS56150072A/en
Publication of JPS6140229B2 publication Critical patent/JPS6140229B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NEW MATERIAL:A quinazoline derivative expressed by formula I [ R is H, alkyl, or phenyl which may have alkyl, alkoxyl or halogen as a substituent group; n is an integer 0W3, m is an integer 1W3; [O(CH2)nR]2 may form an alkylenedioxy group; X is 2 or 3, however, R is not H when x is 3 and n is 1] and a pharmacologically acceptable acid addition salt thereof.
EXAMPLE: 4-Amino-2-[ 4-( 4-methoxybenzoyl )-1-piperazinyl ]-6,7-dimethoxyquinazoline.
USE: An antihypertensive agent having a slow and prolonged antihypertensive action.
PROCESS: A 2-halogenoquinazoline derivative of formula II (X is halogen) is condensed with a cyclic diamine of formula III by the dehydrohalogenation reaction.
COPYRIGHT: (C)1981,JPO&Japio
JP5275480A 1980-02-13 1980-04-21 Novel quinazoline derivative and its preparation Granted JPS56150072A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP5275480A JPS56150072A (en) 1980-04-21 1980-04-21 Novel quinazoline derivative and its preparation
US06/233,679 US4426382A (en) 1980-02-13 1981-02-11 4-Amino-6,7-dimethoxy-2-piperazinylquinazoline derivatives, their preparation and use
GB8104185A GB2068961B (en) 1980-02-13 1981-02-11 Quinazoline derivatives
CA000370761A CA1154765A (en) 1980-02-13 1981-02-12 4-amino-6, 7-dimethoxy-2-piperazinylquinazoline derivatives, their preparation and use
CH94481A CH644857A5 (en) 1980-02-13 1981-02-12 PIPERAZINYL CHINAZOLINE AND HOMOPIPERAZINYL CHINAZOLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING SUCH DERIVATIVES.
ES499377A ES8207169A1 (en) 1980-02-13 1981-02-12 4-Amino-6,7-dimethoxy-2-piperazinylquinazoline derivatives, their preparation and use
DE19813105330 DE3105330A1 (en) 1980-02-13 1981-02-13 "4-AMINO-6,7-DIMETHOXY-2-PIPERAZINYL CHINAZOLINE DERIVATIVES, THEIR PRODUCTION AND THEIR USE"
IT67213/81A IT1172225B (en) 1980-02-13 1981-02-13 DERIVATIVES OF 4-AMINO-6,7-DIMETOXY-2-PIPERAZINYL-CHINAZOLINE, THEIR PREPARATION AND USE
NL8100726A NL191208C (en) 1980-02-13 1981-02-13 4-Amino-6,7-dimethoxy-2- [4- (substituted carbonyl) -1-piperazinylquinazoline compounds having antihypertensive activity and pharmaceutical compositions containing these compounds.
FR8102821A FR2475548A1 (en) 1980-02-13 1981-02-13 NOVEL QUINAZOLINE DERIVATIVES, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5275480A JPS56150072A (en) 1980-04-21 1980-04-21 Novel quinazoline derivative and its preparation

Publications (2)

Publication Number Publication Date
JPS56150072A true JPS56150072A (en) 1981-11-20
JPS6140229B2 JPS6140229B2 (en) 1986-09-08

Family

ID=12923674

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5275480A Granted JPS56150072A (en) 1980-02-13 1980-04-21 Novel quinazoline derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS56150072A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57116052A (en) * 1981-01-13 1982-07-19 Sankyo Co Ltd Quinazoline derivative and its preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57116052A (en) * 1981-01-13 1982-07-19 Sankyo Co Ltd Quinazoline derivative and its preparation
JPH025751B2 (en) * 1981-01-13 1990-02-05 Sankyo Co

Also Published As

Publication number Publication date
JPS6140229B2 (en) 1986-09-08

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