IT1172225B - Derivati della 4-ammino-6,7-dimetossi-2-piperazinil-chinazolina, loro preparazione ed impiego - Google Patents

Derivati della 4-ammino-6,7-dimetossi-2-piperazinil-chinazolina, loro preparazione ed impiego

Info

Publication number
IT1172225B
IT1172225B IT67213/81A IT6721381A IT1172225B IT 1172225 B IT1172225 B IT 1172225B IT 67213/81 A IT67213/81 A IT 67213/81A IT 6721381 A IT6721381 A IT 6721381A IT 1172225 B IT1172225 B IT 1172225B
Authority
IT
Italy
Prior art keywords
dimetoxy
chinazoline
piperazinyl
derivatives
amino
Prior art date
Application number
IT67213/81A
Other languages
English (en)
Other versions
IT8167213A0 (it
Inventor
Sato Yasunobu
Fukumi Hiroshi
Koike Hiroyuki
Nishino Hiroshi
Original Assignee
Sankyo Co Ltd Td
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1677580A external-priority patent/JPS56113770A/ja
Priority claimed from JP5275480A external-priority patent/JPS56150072A/ja
Priority claimed from JP9610780A external-priority patent/JPS5721385A/ja
Priority claimed from JP9610680A external-priority patent/JPS5721384A/ja
Application filed by Sankyo Co Ltd Td filed Critical Sankyo Co Ltd Td
Publication of IT8167213A0 publication Critical patent/IT8167213A0/it
Application granted granted Critical
Publication of IT1172225B publication Critical patent/IT1172225B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT67213/81A 1980-02-13 1981-02-13 Derivati della 4-ammino-6,7-dimetossi-2-piperazinil-chinazolina, loro preparazione ed impiego IT1172225B (it)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP1677580A JPS56113770A (en) 1980-02-13 1980-02-13 Novel quinazoline derivative and its preparation
JP5275480A JPS56150072A (en) 1980-04-21 1980-04-21 Novel quinazoline derivative and its preparation
JP9610780A JPS5721385A (en) 1980-07-14 1980-07-14 Novel aminoquinazoline derivative and its preparation
JP9610680A JPS5721384A (en) 1980-07-14 1980-07-14 Novel aminoquinazoline derivative and its preparation

Publications (2)

Publication Number Publication Date
IT8167213A0 IT8167213A0 (it) 1981-02-13
IT1172225B true IT1172225B (it) 1987-06-18

Family

ID=27456647

Family Applications (1)

Application Number Title Priority Date Filing Date
IT67213/81A IT1172225B (it) 1980-02-13 1981-02-13 Derivati della 4-ammino-6,7-dimetossi-2-piperazinil-chinazolina, loro preparazione ed impiego

Country Status (9)

Country Link
US (1) US4426382A (it)
CA (1) CA1154765A (it)
CH (1) CH644857A5 (it)
DE (1) DE3105330A1 (it)
ES (1) ES8207169A1 (it)
FR (1) FR2475548A1 (it)
GB (1) GB2068961B (it)
IT (1) IT1172225B (it)
NL (1) NL191208C (it)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS236097B1 (en) * 1983-06-01 1985-05-15 Jan Koenig Acylderivatives of 2-piperazinochinazoline and method of their preparation
DE3346675A1 (de) * 1983-12-23 1985-07-04 Beiersdorf Ag, 2000 Hamburg Substituierte 1-(4-amino-6,7-dialkoxy-chinazolinyl)-4- cyclohexenyl-derivate des piperazins und homopiperazins, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen und zwischenprodukte
JPH0647540B2 (ja) * 1985-07-16 1994-06-22 エーザイ株式会社 虚血性心疾患・不整脈治療・予防剤
IT1270993B (it) * 1994-03-18 1997-05-26 Recordati Chem Pharm Derivati chinzolilamminici attivi come alfa-antagonisti
TWI350168B (en) * 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
US8685961B2 (en) * 2006-03-29 2014-04-01 Merck Sharp & Dohme Corp. Diazepan orexin receptor antagonists
PE20081229A1 (es) * 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
US8653262B2 (en) 2007-05-31 2014-02-18 Boehringer Ingelheim International Gmbh CCR2 receptor antagonists and uses thereof
WO2009143404A1 (en) * 2008-05-23 2009-11-26 Wyeth Piperazine metabotropic glutamate receptor 5 (mglur5) negative allosteric modulators for anxiety/depression
PL2379525T3 (pl) 2008-12-19 2016-01-29 Centrexion Therapeutics Corp Cykliczne pirymidyno-4-karboksamidy jako antagoniści receptora CCR2 do leczenia stanów zapalnych, astmy oraz COPD
JP5632014B2 (ja) 2009-12-17 2014-11-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規ｃｃｒ２受容体アンタゴニスト及びこれらの使用
EP2569298B1 (en) 2010-05-12 2015-11-25 Boehringer Ingelheim International GmbH Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
EP2569295B1 (en) 2010-05-12 2014-11-19 Boehringer Ingelheim International GmbH New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
JP5647339B2 (ja) 2010-05-17 2014-12-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ２アンタゴニスト及びこれらの使用
EP2576542B1 (en) 2010-05-25 2015-04-22 Boehringer Ingelheim International GmbH Cyclic amide derivatives of pyridazine-3-carboxylic acids and their use in the treatment of pulmonary, pain, immune related and cardiovascular diseases
US8962656B2 (en) 2010-06-01 2015-02-24 Boehringer Ingelheim International Gmbh CCR2 antagonists
EP2731941B1 (en) 2011-07-15 2019-05-08 Boehringer Ingelheim International GmbH Novel and selective ccr2 antagonists
US9260441B2 (en) * 2012-03-28 2016-02-16 Intervet Inc. Heteroaryl compounds with cyclic bridging unit
EP2864322B1 (en) 2012-06-20 2016-04-27 Novartis AG Complement pathway modulators and uses thereof
WO2015095111A1 (en) 2013-12-18 2015-06-25 Merck Sharp & Dohme Corp. Diazepane orexin receptor antagonists
WO2017004537A1 (en) 2015-07-02 2017-01-05 Centrexion Therapeutics Corporation (4-((3r,4r)-3-methoxytetrahydro-pyran-4-ylamino)piperidin-1-yl)(5-methyl-6-(((2r,6s)-6-(p-tolyl)tetrahydro-2h-pyran-2-yl)methylamino)pyrimidin-4yl)methanone citrate
WO2019010180A1 (en) * 2017-07-06 2019-01-10 Case Western Reserve University PEPTIDE AND SMALL MOLECULE AGONISTS OF EPHA AND USES THEREOF

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3511836A (en) * 1967-12-13 1970-05-12 Pfizer & Co C 2,4,6,7-tetra substituted quinazolines
US3635979A (en) 1969-09-29 1972-01-18 Pfizer Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines
JPS4966691A (it) * 1972-10-30 1974-06-27
US3935213A (en) 1973-12-05 1976-01-27 Pfizer Inc. Process for hypotensive 4-amino-2-(piperazin-1-yl) quinazoline derivatives
US4060615A (en) * 1976-02-18 1977-11-29 Mead Johnson & Company 2-Piperazinyl-6,7-dimethoxyquinazolines
US4001237A (en) * 1976-02-18 1977-01-04 Bristol-Myers Company Oxazole, isoxazole, thiazole and isothiazole amides
US4189484A (en) * 1977-11-08 1980-02-19 Mitsubishi Yuka Pharmaceutical Co., Ltd. Antihypertensive quinazoline derivatives
US4287341A (en) 1979-11-01 1981-09-01 Pfizer Inc. Alkoxy-substituted-6-chloro-quinazoline-2,4-diones
JPS5728576A (en) * 1980-07-24 1982-02-16 Toshiba Corp Inverter device

Also Published As

Publication number Publication date
CH644857A5 (de) 1984-08-31
NL8100726A (nl) 1981-09-16
NL191208C (nl) 1995-03-16
ES499377A0 (es) 1982-09-01
GB2068961B (en) 1983-11-30
FR2475548B1 (it) 1983-06-24
CA1154765A (en) 1983-10-04
US4426382A (en) 1984-01-17
FR2475548A1 (fr) 1981-08-14
DE3105330A1 (de) 1981-12-17
DE3105330C2 (it) 1991-07-25
IT8167213A0 (it) 1981-02-13
GB2068961A (en) 1981-08-19
NL191208B (nl) 1994-10-17
ES8207169A1 (es) 1982-09-01

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Effective date: 19950227