ES8202341A1 - Un procedimiento para preparar derivados de la ergolin. - Google Patents
Un procedimiento para preparar derivados de la ergolin.Info
- Publication number
- ES8202341A1 ES8202341A1 ES482092A ES482092A ES8202341A1 ES 8202341 A1 ES8202341 A1 ES 8202341A1 ES 482092 A ES482092 A ES 482092A ES 482092 A ES482092 A ES 482092A ES 8202341 A1 ES8202341 A1 ES 8202341A1
- Authority
- ES
- Spain
- Prior art keywords
- azaergolines
- ergolenes
- aza
- preparation
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZFOZPCILROUMEK-LDYMZIIASA-N (2R,7R)-6,10,11-triazatetracyclo[7.6.1.02,7.012,16]hexadeca-1(15),9(16),11,13-tetraene Chemical class C1=CC([C@@H]2[C@H](NCCC2)C2)=C3C2=NNC3=C1 ZFOZPCILROUMEK-LDYMZIIASA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 abstract 2
- PDJMKPRMBSMVFX-UHFFFAOYSA-N 7-amino-5h-benzo[f]quinolin-6-one Chemical compound C12=CC=CN=C2CC(=O)C2=C1C=CC=C2N PDJMKPRMBSMVFX-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012954 diazonium Substances 0.000 abstract 1
- 238000006193 diazotization reaction Methods 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 239000003176 neuroleptic agent Substances 0.000 abstract 1
- 235000010288 sodium nitrite Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE ERGOLINA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (I) CON NITRILO EN PRESENCIA DE UN ACIDO MINERAL FUERTE, SEGUIDO DE LA REACCION CON UN AGENTE REDUCTOR. OPCIONALMENTE SE HACE REACCIONAR EL COMPUESTO OBTENIDO COM MEFOXIDO DE SODIO O LA SAL DE SODIO DEL ACIDO METANOSULFINILO. OPCIONALMENTE SE PUEDEN REDUCIR LOS COMPUESTOS OBTENIDOS CON CLORURO DE TIONILO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/021,055 US4201862A (en) | 1979-03-16 | 1979-03-16 | 2-Azaergolines and 2-aza-8(or 9)-ergolenes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES482092A0 ES482092A0 (es) | 1980-08-01 |
| ES8202341A1 true ES8202341A1 (es) | 1980-08-01 |
Family
ID=21802089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES482092A Expired ES8202341A1 (es) | 1979-03-16 | 1979-06-29 | Un procedimiento para preparar derivados de la ergolin. |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US4201862A (es) |
| EP (1) | EP0016274B1 (es) |
| JP (1) | JPS55124782A (es) |
| AR (1) | AR222178A1 (es) |
| AT (1) | AT371465B (es) |
| AU (1) | AU528075B2 (es) |
| BE (1) | BE877263A (es) |
| CA (2) | CA1107275A (es) |
| CH (1) | CH641803A5 (es) |
| CS (1) | CS213380B2 (es) |
| DD (1) | DD144671A5 (es) |
| DE (1) | DE2964803D1 (es) |
| DK (1) | DK268379A (es) |
| EG (1) | EG14250A (es) |
| ES (1) | ES8202341A1 (es) |
| FI (1) | FI66381C (es) |
| FR (1) | FR2451375A1 (es) |
| GB (1) | GB2044247B (es) |
| GR (1) | GR72397B (es) |
| HU (1) | HU181678B (es) |
| IE (1) | IE48360B1 (es) |
| IL (1) | IL57667A (es) |
| LU (1) | LU81437A1 (es) |
| NZ (1) | NZ190832A (es) |
| PH (1) | PH15302A (es) |
| PL (1) | PL128622B1 (es) |
| PT (1) | PT69832A (es) |
| RO (1) | RO76166A (es) |
| SU (1) | SU1005662A3 (es) |
| YU (1) | YU154679A (es) |
| ZA (1) | ZA793246B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL65269A0 (en) * | 1981-03-24 | 1982-05-31 | Lilly Co Eli | 6-substituted hexahydroindazolo or hexahydroisoindolo isoquinolines |
| GB2112382B (en) * | 1981-11-06 | 1985-03-06 | Erba Farmitalia | Ergoline derivatives |
| GB8419278D0 (en) * | 1984-07-27 | 1984-08-30 | Lilly Industries Ltd | Pharmaceutical compounds |
| US4798834A (en) * | 1987-08-31 | 1989-01-17 | Eli Lilly And Company | Optionally substituted (3β-9,10-didehydro-2,3-dihydro ergoline as serotonergic function enhancement |
| JPH02111285U (es) * | 1989-02-27 | 1990-09-05 | ||
| JPH0625197U (ja) * | 1992-01-14 | 1994-04-05 | 森下株式会社 | 網製輸送袋 |
-
1979
- 1979-03-16 US US06/021,055 patent/US4201862A/en not_active Expired - Lifetime
- 1979-06-26 NZ NZ190832A patent/NZ190832A/xx unknown
- 1979-06-26 AU AU48413/79A patent/AU528075B2/en not_active Ceased
- 1979-06-26 HU HU79EI861A patent/HU181678B/hu unknown
- 1979-06-26 IL IL57667A patent/IL57667A/xx unknown
- 1979-06-26 BE BE1/9434A patent/BE877263A/xx not_active IP Right Cessation
- 1979-06-26 DK DK268379A patent/DK268379A/da not_active Application Discontinuation
- 1979-06-26 FR FR7916420A patent/FR2451375A1/fr active Granted
- 1979-06-27 PT PT69832A patent/PT69832A/pt unknown
- 1979-06-27 LU LU81437A patent/LU81437A1/xx unknown
- 1979-06-27 RO RO7997971A patent/RO76166A/ro unknown
- 1979-06-27 PH PH22703A patent/PH15302A/en unknown
- 1979-06-27 CA CA330,695A patent/CA1107275A/en not_active Expired
- 1979-06-28 FI FI792044A patent/FI66381C/fi not_active IP Right Cessation
- 1979-06-28 YU YU01546/79A patent/YU154679A/xx unknown
- 1979-06-28 CS CS794481A patent/CS213380B2/cs unknown
- 1979-06-28 SU SU792786204A patent/SU1005662A3/ru active
- 1979-06-28 CH CH605979A patent/CH641803A5/fr not_active IP Right Cessation
- 1979-06-28 JP JP8340879A patent/JPS55124782A/ja active Granted
- 1979-06-28 GR GR59462A patent/GR72397B/el unknown
- 1979-06-28 EP EP79301249A patent/EP0016274B1/en not_active Expired
- 1979-06-28 GB GB7922529A patent/GB2044247B/en not_active Expired
- 1979-06-28 DE DE7979301249T patent/DE2964803D1/de not_active Expired
- 1979-06-28 AT AT0452379A patent/AT371465B/de not_active IP Right Cessation
- 1979-06-29 ZA ZA793246A patent/ZA793246B/xx unknown
- 1979-06-29 DD DD79213991A patent/DD144671A5/de unknown
- 1979-06-29 ES ES482092A patent/ES8202341A1/es not_active Expired
- 1979-06-29 AR AR277116A patent/AR222178A1/es active
- 1979-06-29 PL PL1979216720A patent/PL128622B1/pl unknown
- 1979-08-08 IE IE1212/79A patent/IE48360B1/en unknown
-
1980
- 1980-02-13 EG EG84/80A patent/EG14250A/xx active
-
1982
- 1982-08-18 CA CA000409720A patent/CA1142176B/en not_active Expired
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