ES8202331A1 - Un procedimiento para preparar 5-ciano-(3,4'-bipiridin)-6 (1h)-ona - Google Patents

Un procedimiento para preparar 5-ciano-(3,4'-bipiridin)-6 (1h)-ona

Info

Publication number
ES8202331A1
ES8202331A1 ES499775A ES499775A ES8202331A1 ES 8202331 A1 ES8202331 A1 ES 8202331A1 ES 499775 A ES499775 A ES 499775A ES 499775 A ES499775 A ES 499775A ES 8202331 A1 ES8202331 A1 ES 8202331A1
Authority
ES
Spain
Prior art keywords
bipyridin
cyano
picoline
temperature
low
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES499775A
Other languages
English (en)
Other versions
ES499775A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of ES499775A0 publication Critical patent/ES499775A0/es
Publication of ES8202331A1 publication Critical patent/ES8202331A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/22—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing two or more pyridine rings directly linked together, e.g. bipyridyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 5-CIANO-(3,4''-BIRIPIDIN)-6-(1H)-ONA EN FORMA DE BASE LIBRE O COMO UNA SAL CATIONICA DE LA MISMA. SE HACE REACIONAR 4-PICILINA CON, AL MENOS, TRES EQUIVALENTES MOLARES DE UN HALOGENURO DE ACIDO INORGANICO Y CON UN EXCESO DE DIMETIL FORMAMIDA. SE INCORPORA A LA MEZCLA AGUA Y SE AJUSTA EL PH A UN VALOR DE 8, CON LO QUE PRECIPITA LA SAL CATIONICA N-(O-DIMETILAMINO-2-(4-PIRIDINIL)-I-PORPENILIDENO)-N-METILMETANIMI-NIO, QUE SE TRATA CON UN EXCESO DE ALFA-CIANOACETAMIDA Y CON, EL MENOS, TRES EQUIVALETES MOLARES DE UNA BASE PARA OBTENER EL COMPUESTO DESEADO. EN TODO EL PROCESO, LA TEMPERATURA SE MANTIENE POR DEBAJO DE LOS 30 C. DE APLICACION COMO COMPUESTO INTERMEDIO EN LA PREPARACION DE 3-AMINO-5-(4-PIRIDINIL)-2-1H)-PIRIDINONA.
ES499775A 1980-02-26 1981-02-25 Un procedimiento para preparar 5-ciano-(3,4'-bipiridin)-6 (1h)-ona Expired ES8202331A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/124,807 US4310670A (en) 1980-02-26 1980-02-26 Low-temperature, aqueous conversion of 4-picoline derivative to 5-cyano-[3,4'-bipyridin]-6(1H)-one

Publications (2)

Publication Number Publication Date
ES499775A0 ES499775A0 (es) 1982-01-16
ES8202331A1 true ES8202331A1 (es) 1982-01-16

Family

ID=22416874

Family Applications (1)

Application Number Title Priority Date Filing Date
ES499775A Expired ES8202331A1 (es) 1980-02-26 1981-02-25 Un procedimiento para preparar 5-ciano-(3,4'-bipiridin)-6 (1h)-ona

Country Status (23)

Country Link
US (1) US4310670A (es)
JP (1) JPS56150065A (es)
KR (1) KR830005142A (es)
AT (1) AT375068B (es)
AU (1) AU6748881A (es)
BE (1) BE887662A (es)
CA (1) CA1128518A (es)
DE (1) DE3107280A1 (es)
DK (1) DK83881A (es)
ES (1) ES8202331A1 (es)
FI (1) FI810583L (es)
FR (1) FR2476648A1 (es)
GB (1) GB2070008B (es)
IL (1) IL62159A (es)
IT (1) IT1169216B (es)
LU (1) LU83170A1 (es)
NL (1) NL8100923A (es)
NO (1) NO810638L (es)
NZ (1) NZ196281A (es)
PH (1) PH15837A (es)
PT (1) PT72572B (es)
SE (1) SE431748B (es)
ZA (1) ZA811123B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ204175A (en) * 1982-05-24 1985-12-13 Sterling Drug Inc Preparation of 1,2-dihydro-6-(lower alkyl)-2-oxo-5-(pyridinyl)-nicotinonitriles and nicotinamides;and pyridine intermediates therefor
DE3842062A1 (de) * 1988-12-14 1990-06-28 Hoechst Ag Explosionssichere 1-dimethylamino-3-dimethylimino-2-arylpropen-1-salze, verfahren zu ihrer herstellung und ihre verwendung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072746A (en) * 1975-10-14 1978-02-07 Sterling Drug Inc. 3-Amino-5-(pyridinyl)-2(1H)-pyridinones
US4004012A (en) * 1975-10-14 1977-01-18 Sterling Drug Inc. 3-Cyano-5-(pyridinyl)-2(1H)-pyridinones

Also Published As

Publication number Publication date
FR2476648A1 (fr) 1981-08-28
AT375068B (de) 1984-06-25
IL62159A0 (en) 1981-03-31
SE431748B (sv) 1984-02-27
IL62159A (en) 1984-06-29
GB2070008B (en) 1984-04-18
JPS56150065A (en) 1981-11-20
ES499775A0 (es) 1982-01-16
NZ196281A (en) 1983-12-16
DK83881A (da) 1981-08-27
PH15837A (en) 1983-04-08
PT72572A (en) 1981-03-01
GB2070008A (en) 1981-09-03
NL8100923A (nl) 1981-09-16
KR830005142A (ko) 1983-08-03
IT8119951A0 (it) 1981-02-24
ATA88481A (de) 1983-11-15
BE887662A (fr) 1981-08-25
CA1128518A (en) 1982-07-27
AU6748881A (en) 1981-09-03
PT72572B (en) 1982-03-19
SE8101204L (sv) 1981-08-27
IT1169216B (it) 1987-05-27
ZA811123B (en) 1982-03-31
US4310670A (en) 1982-01-12
LU83170A1 (fr) 1981-09-11
DE3107280A1 (de) 1982-01-07
FI810583L (fi) 1981-08-27
NO810638L (no) 1981-08-27

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