JPS5473783A - Pyridine derivative - Google Patents

Pyridine derivative

Info

Publication number
JPS5473783A
JPS5473783A JP13741677A JP13741677A JPS5473783A JP S5473783 A JPS5473783 A JP S5473783A JP 13741677 A JP13741677 A JP 13741677A JP 13741677 A JP13741677 A JP 13741677A JP S5473783 A JPS5473783 A JP S5473783A
Authority
JP
Japan
Prior art keywords
formula
compound
iii
pyridine derivative
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13741677A
Other languages
Japanese (ja)
Other versions
JPS5728710B2 (en
Inventor
Tadao Sato
Minoru Uchida
Fujio Tafusa
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP13741677A priority Critical patent/JPS5473783A/en
Publication of JPS5473783A publication Critical patent/JPS5473783A/en
Publication of JPS5728710B2 publication Critical patent/JPS5728710B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A pyridine derivative of formula I: (R is lower alkyl or phenylalkyl group; X is O or S), or its acid salt.
EXAMPLE: 1-Methyl-3-(2-pyridyl)-2-quinolone.
USE: Antipeptic ulcer drugs and hypotensives having gostric secretion inhibitory and hypotensive actions.
PROCESS: A compound of formula II is reacted with a compound of formula III: (X1 is halogen) at a molar ratio of II to III of 1:1W2 in the presence of a dehydrohalogenating agent, e.g. n-butyllithium, lithium hydride, etc., at room temperatureW200°C, preferably 50W150°C for 1W30 hr, preferably 1W15 hr to give the compound of formula I. The compound of formula II, wherein X is S, is a novel compound of formula IIb, which is obtained by reacting a compound of formula II a with phosphorus pentasulfide in a solvent, e.g. benzene, dioxane, etc. in the presence of pyridine.
COPYRIGHT: (C)1979,JPO&Japio
JP13741677A 1977-11-15 1977-11-15 Pyridine derivative Granted JPS5473783A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13741677A JPS5473783A (en) 1977-11-15 1977-11-15 Pyridine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13741677A JPS5473783A (en) 1977-11-15 1977-11-15 Pyridine derivative

Publications (2)

Publication Number Publication Date
JPS5473783A true JPS5473783A (en) 1979-06-13
JPS5728710B2 JPS5728710B2 (en) 1982-06-18

Family

ID=15198112

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13741677A Granted JPS5473783A (en) 1977-11-15 1977-11-15 Pyridine derivative

Country Status (1)

Country Link
JP (1) JPS5473783A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0236140A2 (en) * 1986-03-05 1987-09-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
US4710507A (en) * 1983-12-22 1987-12-01 Pfizer Inc. Quinolone inotropic agents
US4728653A (en) * 1984-05-29 1988-03-01 Pfizer Inc. 6-heteroaryl quinolone inotropic agents
US4740513A (en) * 1985-11-28 1988-04-26 Pfizer Inc. Methyl substituted imidazol-1-yl quinolones
US5064837A (en) * 1989-11-13 1991-11-12 Schering Corporation 3-substituted-1-aryl-2(h)-quinolones and their pharmaceutical compositions
US5260442A (en) * 1990-12-14 1993-11-09 Imperial Chemical Industries Plc Process for the manufacture of crystalline quinolinium salts and their oxidation to 1-alkyl-2-quinolones
US5358949A (en) * 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6372394A (en) * 1986-05-29 1988-04-02 Tsurumi Mfg Co Ltd Method and apparatus for treating sewage

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4710507A (en) * 1983-12-22 1987-12-01 Pfizer Inc. Quinolone inotropic agents
US4728653A (en) * 1984-05-29 1988-03-01 Pfizer Inc. 6-heteroaryl quinolone inotropic agents
US4740513A (en) * 1985-11-28 1988-04-26 Pfizer Inc. Methyl substituted imidazol-1-yl quinolones
EP0236140A2 (en) * 1986-03-05 1987-09-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
US5358949A (en) * 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
US5064837A (en) * 1989-11-13 1991-11-12 Schering Corporation 3-substituted-1-aryl-2(h)-quinolones and their pharmaceutical compositions
US5318971A (en) * 1989-11-13 1994-06-07 Schering Corporation 3-Substituted-1-aryl-2(1H)-quinolones useful as anti-allergy and anti-inflammatory agents
US5260442A (en) * 1990-12-14 1993-11-09 Imperial Chemical Industries Plc Process for the manufacture of crystalline quinolinium salts and their oxidation to 1-alkyl-2-quinolones
US5446165A (en) * 1990-12-14 1995-08-29 Zeneca Limited Crystalline 1-alkyl-2-quinolinium salts

Also Published As

Publication number Publication date
JPS5728710B2 (en) 1982-06-18

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