JPS5473783A - Pyridine derivative - Google Patents
Pyridine derivativeInfo
- Publication number
- JPS5473783A JPS5473783A JP13741677A JP13741677A JPS5473783A JP S5473783 A JPS5473783 A JP S5473783A JP 13741677 A JP13741677 A JP 13741677A JP 13741677 A JP13741677 A JP 13741677A JP S5473783 A JPS5473783 A JP S5473783A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- iii
- pyridine derivative
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A pyridine derivative of formula I: (R is lower alkyl or phenylalkyl group; X is O or S), or its acid salt.
EXAMPLE: 1-Methyl-3-(2-pyridyl)-2-quinolone.
USE: Antipeptic ulcer drugs and hypotensives having gostric secretion inhibitory and hypotensive actions.
PROCESS: A compound of formula II is reacted with a compound of formula III: (X1 is halogen) at a molar ratio of II to III of 1:1W2 in the presence of a dehydrohalogenating agent, e.g. n-butyllithium, lithium hydride, etc., at room temperatureW200°C, preferably 50W150°C for 1W30 hr, preferably 1W15 hr to give the compound of formula I. The compound of formula II, wherein X is S, is a novel compound of formula IIb, which is obtained by reacting a compound of formula II a with phosphorus pentasulfide in a solvent, e.g. benzene, dioxane, etc. in the presence of pyridine.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13741677A JPS5473783A (en) | 1977-11-15 | 1977-11-15 | Pyridine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13741677A JPS5473783A (en) | 1977-11-15 | 1977-11-15 | Pyridine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5473783A true JPS5473783A (en) | 1979-06-13 |
JPS5728710B2 JPS5728710B2 (en) | 1982-06-18 |
Family
ID=15198112
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13741677A Granted JPS5473783A (en) | 1977-11-15 | 1977-11-15 | Pyridine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5473783A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0236140A2 (en) * | 1986-03-05 | 1987-09-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives |
US4710507A (en) * | 1983-12-22 | 1987-12-01 | Pfizer Inc. | Quinolone inotropic agents |
US4728653A (en) * | 1984-05-29 | 1988-03-01 | Pfizer Inc. | 6-heteroaryl quinolone inotropic agents |
US4740513A (en) * | 1985-11-28 | 1988-04-26 | Pfizer Inc. | Methyl substituted imidazol-1-yl quinolones |
US5064837A (en) * | 1989-11-13 | 1991-11-12 | Schering Corporation | 3-substituted-1-aryl-2(h)-quinolones and their pharmaceutical compositions |
US5260442A (en) * | 1990-12-14 | 1993-11-09 | Imperial Chemical Industries Plc | Process for the manufacture of crystalline quinolinium salts and their oxidation to 1-alkyl-2-quinolones |
US5358949A (en) * | 1986-03-05 | 1994-10-25 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6372394A (en) * | 1986-05-29 | 1988-04-02 | Tsurumi Mfg Co Ltd | Method and apparatus for treating sewage |
-
1977
- 1977-11-15 JP JP13741677A patent/JPS5473783A/en active Granted
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4710507A (en) * | 1983-12-22 | 1987-12-01 | Pfizer Inc. | Quinolone inotropic agents |
US4728653A (en) * | 1984-05-29 | 1988-03-01 | Pfizer Inc. | 6-heteroaryl quinolone inotropic agents |
US4740513A (en) * | 1985-11-28 | 1988-04-26 | Pfizer Inc. | Methyl substituted imidazol-1-yl quinolones |
EP0236140A2 (en) * | 1986-03-05 | 1987-09-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives |
US5358949A (en) * | 1986-03-05 | 1994-10-25 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives |
US5064837A (en) * | 1989-11-13 | 1991-11-12 | Schering Corporation | 3-substituted-1-aryl-2(h)-quinolones and their pharmaceutical compositions |
US5318971A (en) * | 1989-11-13 | 1994-06-07 | Schering Corporation | 3-Substituted-1-aryl-2(1H)-quinolones useful as anti-allergy and anti-inflammatory agents |
US5260442A (en) * | 1990-12-14 | 1993-11-09 | Imperial Chemical Industries Plc | Process for the manufacture of crystalline quinolinium salts and their oxidation to 1-alkyl-2-quinolones |
US5446165A (en) * | 1990-12-14 | 1995-08-29 | Zeneca Limited | Crystalline 1-alkyl-2-quinolinium salts |
Also Published As
Publication number | Publication date |
---|---|
JPS5728710B2 (en) | 1982-06-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8307806A1 (en) | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them. | |
IE810108L (en) | IMIDAZO £1,2-a| PYRIDINES | |
AU589427B2 (en) | Pyridonecarboxylic acid derivatives and process for their preparation | |
PH21007A (en) | Quinoline carboxylic acid derivatives and a process for the preparation thereof | |
PT83104A (en) | Novel guanidinomethylbenzoic acid derivatives | |
JPS5473783A (en) | Pyridine derivative | |
DE3063189D1 (en) | New derivatives of the 9-cis-6,6'-diapo-psi,psi-carotenedioic acid, preparation thereof and pharmaceutical compositions containing same | |
IE43519L (en) | Benzimidazole-2-carbamates | |
EP0330939A3 (en) | Acrylic acid morpholides, their production and use | |
MY109491A (en) | Pyridinyl-quinolone compounds, their preparation and use. | |
ES8401942A1 (en) | New compounds with antiinflammatory and antitussive activity, process for their preparation and relative pharmaceutical compositions. | |
NO178660C (en) | Analogous process for the preparation of N-aryl-piperazine alkanamide compounds | |
GB1382770A (en) | Isoindoline derivatives | |
ES475361A1 (en) | Pyridine derivative, its preparation and use | |
IE45269L (en) | 8-hydroxy-5-(3-amino-2-hydroxypropoxy) carbostyrils | |
IE37506L (en) | Pyridine carboxylic acid esters. | |
EP0331080A3 (en) | Imidazole derivatives, process for production thereof, and use thereof | |
EP0143630A3 (en) | Chemical compounds | |
JPS55133366A (en) | Thiazole derivative | |
ES8702399A1 (en) | 1,5-Benzoxathiepin derivatives, their production and use. | |
JPS5576872A (en) | Imidazolidinone derivative | |
ES8602764A1 (en) | Aminothiadiazine derivatives as histamine H2-antagonists. | |
FI883760A0 (en) | Process for the preparation of therapeutically useful tetrahydroisoquinoline derivatives | |
JPS5470277A (en) | Hydroxyindole derivatives | |
JPS643181A (en) | Pyridonecarboxylic acid derivative |