ES8200110A1 - Un procedimiento para preparar la sal de d-sesquisodio del compuesto diacido de oxa-beta-lactama - Google Patents

Un procedimiento para preparar la sal de d-sesquisodio del compuesto diacido de oxa-beta-lactama

Info

Publication number
ES8200110A1
ES8200110A1 ES490828A ES490828A ES8200110A1 ES 8200110 A1 ES8200110 A1 ES 8200110A1 ES 490828 A ES490828 A ES 490828A ES 490828 A ES490828 A ES 490828A ES 8200110 A1 ES8200110 A1 ES 8200110A1
Authority
ES
Spain
Prior art keywords
preparation
oxa
beta
diacid compound
sesquisodium salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES490828A
Other languages
English (en)
Other versions
ES490828A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES490828A0 publication Critical patent/ES490828A0/es
Publication of ES8200110A1 publication Critical patent/ES8200110A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DEL ISOMERO D DE LA SAL DE SESQUISODIO DEL COMPUESTO DIACIDO DE OXA-B-LACTAMA DE FORMULA (I). SE HACE REACCIONAR LA SAL DISODICA D,L DE FORMULA (II) CON EL DIACIDO D,L DE FORMULA (III), MEDIANTE LA ADICION DE ACETONA A UNA SOLUCION ACUOSA EN LA QUE LA RELACION MOLAR DE LA DISAL AL DIACIDO ESTA COMPRENDIDA ENTRE 1 A 1 Y 6 A 1. POSTERIORMENTE SE ENFRIA LA SOLUCION A UNA TEMPERATURA COMPRENDIDA ENTRE -35 Y -10 C. DE APLICACION EN EL TRATAMIENTO DE INFECCIONES PROVOCADAS POR BACTERIAS TANTO GRAM-POSITIVAS COMO GRAM-NEGATIVAS.
ES490828A 1979-04-24 1980-04-23 Un procedimiento para preparar la sal de d-sesquisodio del compuesto diacido de oxa-beta-lactama Expired ES8200110A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/032,840 US4259485A (en) 1979-04-24 1979-04-24 Crystallization process

Publications (2)

Publication Number Publication Date
ES490828A0 ES490828A0 (es) 1981-10-16
ES8200110A1 true ES8200110A1 (es) 1981-10-16

Family

ID=21867102

Family Applications (1)

Application Number Title Priority Date Filing Date
ES490828A Expired ES8200110A1 (es) 1979-04-24 1980-04-23 Un procedimiento para preparar la sal de d-sesquisodio del compuesto diacido de oxa-beta-lactama

Country Status (34)

Country Link
US (1) US4259485A (es)
EP (1) EP0018760B1 (es)
JP (1) JPS55143992A (es)
KR (1) KR840000036B1 (es)
AR (1) AR225174A1 (es)
AT (1) AT368158B (es)
AU (1) AU531272B2 (es)
BE (1) BE882849A (es)
BG (1) BG34904A3 (es)
CA (1) CA1124236A (es)
CH (1) CH645901A5 (es)
CS (1) CS212347B2 (es)
DD (1) DD150205A5 (es)
DE (1) DE3067412D1 (es)
DK (1) DK172880A (es)
EG (1) EG14334A (es)
ES (1) ES8200110A1 (es)
FI (1) FI801252A (es)
FR (1) FR2455043A1 (es)
GB (1) GB2047703B (es)
GR (1) GR68048B (es)
HU (1) HU182127B (es)
IE (1) IE49703B1 (es)
IL (1) IL59895A (es)
IT (1) IT1141294B (es)
LU (1) LU82384A1 (es)
NZ (1) NZ193482A (es)
PH (1) PH15146A (es)
PL (1) PL124423B1 (es)
PT (1) PT71115A (es)
RO (1) RO79315A (es)
SU (1) SU925251A3 (es)
YU (1) YU108180A (es)
ZA (1) ZA802329B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56103185A (en) * 1980-01-22 1981-08-18 Shionogi & Co Ltd Malonamidoxa-dethia-cephem compound
JPS5711909A (en) * 1980-06-23 1982-01-21 Shionogi & Co Ltd Stable freeze-dried preparation of beta-lactam
JPS597193A (ja) * 1982-07-02 1984-01-14 Shionogi & Co Ltd マロニルメチル基の異性化方法
RU2555360C2 (ru) * 2012-11-06 2015-07-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ определения воды в координационных соединениях

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1085392A (en) * 1976-03-25 1980-09-09 Masayuki Narisada Arylmalonamido-1-oxadethiacephalosporins
GB1557552A (en) * 1977-02-15 1979-12-12 Shionogi & Co 1 oxadethiacepham compounds
CA1100962A (en) * 1977-04-28 1981-05-12 Yoshio Hamashima Haloarylmalonamidooxacephalosporins
JPS609718B2 (ja) * 1977-08-25 1985-03-12 塩野義製薬株式会社 チアジアゾリルチオセフアロスポリン類縁抗生物質
BE871213R (fr) * 1978-10-12 1979-02-01 Shionogi & Co Arylmalonamido-1-oxadethiacephalosporines

Also Published As

Publication number Publication date
DE3067412D1 (en) 1984-05-17
SU925251A3 (ru) 1982-04-30
IT8021527A0 (it) 1980-04-21
FR2455043B1 (es) 1983-08-05
AU531272B2 (en) 1983-08-18
CA1124236A (en) 1982-05-25
KR840000036B1 (ko) 1984-01-28
IT1141294B (it) 1986-10-01
LU82384A1 (fr) 1980-07-31
RO79315A (ro) 1982-08-17
GR68048B (es) 1981-10-29
ATA207380A (de) 1982-01-15
ES490828A0 (es) 1981-10-16
BG34904A3 (en) 1983-12-15
GB2047703B (en) 1983-04-20
AT368158B (de) 1982-09-27
EP0018760B1 (en) 1984-04-11
GB2047703A (en) 1980-12-03
IE49703B1 (en) 1985-11-27
JPS6242915B2 (es) 1987-09-10
JPS55143992A (en) 1980-11-10
US4259485A (en) 1981-03-31
ZA802329B (en) 1981-11-25
EG14334A (en) 1983-12-31
CH645901A5 (fr) 1984-10-31
PL223649A1 (es) 1981-02-13
HU182127B (en) 1983-12-28
AU5763380A (en) 1980-10-30
BE882849A (fr) 1980-10-20
FI801252A (fi) 1980-10-25
PL124423B1 (en) 1983-01-31
YU108180A (en) 1983-02-28
PT71115A (en) 1980-05-01
DD150205A5 (de) 1981-08-19
EP0018760A1 (en) 1980-11-12
NZ193482A (en) 1982-03-23
IE800804L (en) 1980-10-24
CS212347B2 (en) 1982-03-26
FR2455043A1 (fr) 1980-11-21
IL59895A (en) 1983-05-15
DK172880A (da) 1980-10-25
AR225174A1 (es) 1982-02-26
KR830002778A (ko) 1983-05-30
PH15146A (en) 1982-08-24

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