ES8106524A1 - Procedimiento para la preparacion de 10-bromosandwicina y 10-bromoisosandwicina - Google Patents
Procedimiento para la preparacion de 10-bromosandwicina y 10-bromoisosandwicinaInfo
- Publication number
- ES8106524A1 ES8106524A1 ES495651A ES495651A ES8106524A1 ES 8106524 A1 ES8106524 A1 ES 8106524A1 ES 495651 A ES495651 A ES 495651A ES 495651 A ES495651 A ES 495651A ES 8106524 A1 ES8106524 A1 ES 8106524A1
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- methanol
- mixture
- methylene chloride
- bromosandwicina
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 9
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 6
- 239000000203 mixture Substances 0.000 abstract 3
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- QTMDXZNDVAMKGV-UHFFFAOYSA-L copper(ii) bromide Chemical compound [Cu+2].[Br-].[Br-] QTMDXZNDVAMKGV-UHFFFAOYSA-L 0.000 abstract 2
- NJQJGRGGIUNVAB-UHFFFAOYSA-N 2,4,4,6-tetrabromocyclohexa-2,5-dien-1-one Chemical compound BrC1=CC(Br)(Br)C=C(Br)C1=O NJQJGRGGIUNVAB-UHFFFAOYSA-N 0.000 abstract 1
- 229910021590 Copper(II) bromide Inorganic materials 0.000 abstract 1
- 230000031709 bromination Effects 0.000 abstract 1
- 238000005893 bromination reaction Methods 0.000 abstract 1
- ODWXUNBKCRECNW-UHFFFAOYSA-M bromocopper(1+) Chemical compound Br[Cu+] ODWXUNBKCRECNW-UHFFFAOYSA-M 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Confectionery (AREA)
- Prostheses (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Chemical And Physical Treatments For Wood And The Like (AREA)
- Curing Cements, Concrete, And Artificial Stone (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19792941531 DE2941531A1 (de) | 1979-10-13 | 1979-10-13 | 10-bromsandwicin und 10-bromisosandwicin, verfahren zu deren herstellung und deren verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES495651A0 ES495651A0 (es) | 1981-07-01 |
| ES8106524A1 true ES8106524A1 (es) | 1981-07-01 |
Family
ID=6083414
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES495651A Expired ES8106524A1 (es) | 1979-10-13 | 1980-10-06 | Procedimiento para la preparacion de 10-bromosandwicina y 10-bromoisosandwicina |
| ES498188A Expired ES8201160A1 (es) | 1979-10-13 | 1980-12-29 | Procedimiento para la preparacion de 10-bromoisosandwicina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES498188A Expired ES8201160A1 (es) | 1979-10-13 | 1980-12-29 | Procedimiento para la preparacion de 10-bromoisosandwicina |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4558052A (2) |
| EP (1) | EP0029117B1 (2) |
| JP (1) | JPS5681584A (2) |
| AT (1) | ATE3113T1 (2) |
| AU (1) | AU536185B2 (2) |
| CA (1) | CA1147331A (2) |
| DD (2) | DD154488A5 (2) |
| DE (2) | DE2941531A1 (2) |
| DK (2) | DK430780A (2) |
| ES (2) | ES8106524A1 (2) |
| FI (1) | FI69464C (2) |
| GR (1) | GR70381B (2) |
| HU (1) | HU184332B (2) |
| IE (1) | IE50131B1 (2) |
| IL (1) | IL61224A (2) |
| NO (2) | NO154669C (2) |
| NZ (1) | NZ195218A (2) |
| PH (1) | PH16518A (2) |
| PT (1) | PT71896B (2) |
| SU (2) | SU986298A3 (2) |
| ZA (1) | ZA806169B (2) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2941531A1 (de) * | 1979-10-13 | 1981-04-23 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 10-bromsandwicin und 10-bromisosandwicin, verfahren zu deren herstellung und deren verwendung |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1582627A (en) * | 1976-01-16 | 1981-01-14 | Inverni Della Beffa Spa | Derivatives of sandwicine and isosandwicine and pharmaceutical compositions comprising sandwicine isosandwicine and derivatives thereof |
| DE2611162A1 (de) * | 1976-03-17 | 1977-10-06 | Kali Chemie Pharma Gmbh | Neue quartaere derivate von sandwicin und verfahren zu ihrer herstellung |
| DE2941529A1 (de) * | 1979-10-13 | 1981-04-23 | Kali-Chemie Pharma Gmbh, 3000 Hannover | N(pfeil abwaerts)b(pfeil abwaerts) -quartaere derivate von ajmalin und isoajmalin, verfahren und zwischenprodukte zur herstellung der derivate, die derivate enthaltende arzneimittel und die verwendung der derivate |
| DE2941531A1 (de) * | 1979-10-13 | 1981-04-23 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 10-bromsandwicin und 10-bromisosandwicin, verfahren zu deren herstellung und deren verwendung |
| DE2941530A1 (de) * | 1979-10-13 | 1981-04-23 | Kali-Chemie Pharma Gmbh, 3000 Hannover | N (pfeil abwaerts)b(pfeil hoch) -quartaere derivate von sandwicin und isosandwicin, verfahren und zwischenprodukte zur herstellung der derivate, die derivate enthaltende arzneimittel und die verwendung der derivate |
-
1979
- 1979-10-13 DE DE19792941531 patent/DE2941531A1/de not_active Withdrawn
-
1980
- 1980-09-30 FI FI803088A patent/FI69464C/fi not_active IP Right Cessation
- 1980-10-02 SU SU802983701A patent/SU986298A3/ru active
- 1980-10-06 ZA ZA00806169A patent/ZA806169B/xx unknown
- 1980-10-06 ES ES495651A patent/ES8106524A1/es not_active Expired
- 1980-10-07 IE IE2046/80A patent/IE50131B1/en unknown
- 1980-10-07 IL IL61224A patent/IL61224A/xx unknown
- 1980-10-09 DD DD80224432A patent/DD154488A5/de unknown
- 1980-10-09 PH PH24693A patent/PH16518A/en unknown
- 1980-10-09 DD DD80233315A patent/DD201681A5/de unknown
- 1980-10-09 PT PT71896A patent/PT71896B/pt unknown
- 1980-10-10 HU HU802473A patent/HU184332B/hu not_active IP Right Cessation
- 1980-10-10 NZ NZ195218A patent/NZ195218A/xx unknown
- 1980-10-10 EP EP80106152A patent/EP0029117B1/de not_active Expired
- 1980-10-10 DE DE8080106152T patent/DE3062840D1/de not_active Expired
- 1980-10-10 DK DK430780A patent/DK430780A/da not_active Application Discontinuation
- 1980-10-10 CA CA000362117A patent/CA1147331A/en not_active Expired
- 1980-10-10 NO NO803043A patent/NO154669C/no unknown
- 1980-10-10 AT AT80106152T patent/ATE3113T1/de not_active IP Right Cessation
- 1980-10-11 GR GR63124A patent/GR70381B/el unknown
- 1980-10-13 JP JP14215680A patent/JPS5681584A/ja active Granted
- 1980-10-13 AU AU63207/80A patent/AU536185B2/en not_active Ceased
- 1980-12-25 SU SU803220196A patent/SU996416A1/ru active
- 1980-12-29 ES ES498188A patent/ES8201160A1/es not_active Expired
-
1984
- 1984-06-08 US US06/618,908 patent/US4558052A/en not_active Expired - Fee Related
-
1986
- 1986-03-19 NO NO86861078A patent/NO156326C/no unknown
-
1988
- 1988-05-19 DK DK273988A patent/DK273988D0/da unknown
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