ES8304116A1 - Un procedimiento para la preparacion de un dihidroxi-compuesto. - Google Patents

Un procedimiento para la preparacion de un dihidroxi-compuesto.

Info

Publication number
ES8304116A1
ES8304116A1 ES511123A ES511123A ES8304116A1 ES 8304116 A1 ES8304116 A1 ES 8304116A1 ES 511123 A ES511123 A ES 511123A ES 511123 A ES511123 A ES 511123A ES 8304116 A1 ES8304116 A1 ES 8304116A1
Authority
ES
Spain
Prior art keywords
formula
chem
alkyl
benzothiophenes
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES511123A
Other languages
English (en)
Other versions
ES511123A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/331,046 external-priority patent/US4380635A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES8304116A1 publication Critical patent/ES8304116A1/es
Publication of ES511123A0 publication Critical patent/ES511123A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN DIHIDROXI-COMPUESTO, UN ETER, ESTER O SAL DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLE DEL MISMO, DE FORMULA (I), EN LA QUE R Y R SON ALQUILO C <- O SE COMBINAN PARA FORMAR POLIETILENO, 2-METIL TETRAMETILENO O OXI-BIS-ETILEN. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), CON UN AGENTE ACILANTE DE FORMULA (III), EN LAS QUE R ES CLORO O BROMO Y R Y R SON LOS MISMOS QUE EN LA FORMULA (I), EN PRESENCIA DE CLORURO O BROMURO DE ALUMINIO; SEGUIDA DE LA REACCION CON METIONINA O UN COMPUESTO DE FORMULA X-S-Y, EN LA QUE X ES HIDROGENO O ALQUILO C <- E Y ES ALQUILO C <- O FENILO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DEL CANCER DE MAMA O DE PROSTATA, LA FIBROCISTITIS DE MAMA Y LA HIPERTROFIA PORSTATICA BENIGNA.
ES511123A 1981-04-03 1982-04-02 Un procedimiento para la preparacion de un dihidroxi-compuesto. Granted ES511123A0 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24633381A 1981-04-03 1981-04-03
US24633581A 1981-04-03 1981-04-03
US33104581A 1981-12-16 1981-12-16
US06/331,046 US4380635A (en) 1981-04-03 1981-12-16 Synthesis of acylated benzothiophenes

Publications (2)

Publication Number Publication Date
ES8304116A1 true ES8304116A1 (es) 1983-02-16
ES511123A0 ES511123A0 (es) 1983-02-16

Family

ID=27500218

Family Applications (1)

Application Number Title Priority Date Filing Date
ES511123A Granted ES511123A0 (es) 1981-04-03 1982-04-02 Un procedimiento para la preparacion de un dihidroxi-compuesto.

Country Status (13)

Country Link
EP (1) EP0062505B1 (es)
BG (1) BG37378A3 (es)
DE (1) DE3264853D1 (es)
DK (1) DK151382A (es)
ES (1) ES511123A0 (es)
FI (1) FI821161L (es)
GB (1) GB2096608B (es)
GR (1) GR78364B (es)
HU (1) HU191084B (es)
IL (1) IL65379A0 (es)
PL (1) PL130584B1 (es)
PT (1) PT74693B (es)
RO (1) RO84584B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4117512A1 (de) * 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
USRE38968E1 (en) 1992-07-28 2006-02-07 Eli Lilly And Company Methods for inhibiting bone loss using 6-hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl-4-[2-(piperidin-1-yl) ethoxyphenylimethanone hydrochloride
TW366342B (en) 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
USRE39049E1 (en) 1992-07-28 2006-03-28 Eli Lilly And Company Methods for inhibiting bone loss
US5462949A (en) * 1993-12-21 1995-10-31 Eli Lilly And Company Methods of inhibiting fertility in women
US5478847A (en) 1994-03-02 1995-12-26 Eli Lilly And Company Methods of use for inhibiting bone loss and lowering serum cholesterol
CA2145614A1 (en) * 1994-03-31 1995-10-01 Jeffrey A. Dodge Intermediates and processes for preparing benzothiophene compounds
US5523416A (en) * 1994-07-22 1996-06-04 Eli Lilly And Company Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes
US5731436A (en) * 1994-08-31 1998-03-24 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
US5631369A (en) * 1994-08-31 1997-05-20 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
CO4410191A1 (es) * 1994-09-19 1997-01-09 Lilly Co Eli SINTESIS DE 3-[4-(2-AMINOETOXI)BENZOIL]-2-ARIL-6- HIDROXIBENZO [b] TIOFENOS
US5629425A (en) * 1994-09-19 1997-05-13 Eli Lilly And Company Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
ES2163587T3 (es) * 1995-02-28 2002-02-01 Lilly Co Eli Compuestos de benzotiofeno, productos intermedios, composiciones y procedimientos.
US6395755B1 (en) * 1995-03-10 2002-05-28 Eli Lilly And Company Benzothiophene pharmaceutical compounds
AU5554996A (en) * 1995-04-21 1996-11-07 Eli Lilly And Company Benzothiophenes with novel basic side chains
US5606076A (en) * 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
CN1068883C (zh) * 1995-06-07 2001-07-25 伊莱利利公司 乙烯次磺酸衍生物的合成方法
EP0888331A4 (en) * 1996-03-19 2001-05-23 Lilly Co Eli SYNTHESIS OF 3- [4- (2-AMINOETHOXY) BENZOYL] -2-ARYL-6-HYDROXY-BENZO [b] THIOPHENES
PE2699A1 (es) * 1996-09-25 1999-02-04 Lilly Co Eli Procedimiento para la sintesis de benzotiofenos
US5916916A (en) * 1996-10-10 1999-06-29 Eli Lilly And Company 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods
AU7261398A (en) * 1997-04-30 1998-11-24 Eli Lilly And Company Processes for preparing benzothiophenes
KR20010020380A (ko) * 1997-04-30 2001-03-15 피터 지. 스트링거 벤조[ｂ]티오펜의 제조 방법 및 중간체
AU7165398A (en) * 1997-04-30 1998-11-24 Eli Lilly And Company A regioselective alkylation process for preparing substituted benzo{b}thiophenes
CA2236254A1 (en) * 1997-04-30 1998-10-30 David Warren Hoard Process for preparing benzo¬b|thiophenes
CA2231013A1 (en) * 1997-04-30 1998-10-30 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals
AU7261498A (en) * 1997-04-30 1998-11-24 Eli Lilly And Company Intermediates and processes for preparing benzo{b}thiophenes
AU2003266940B2 (en) 2002-09-30 2007-02-08 A/S Gea Farmaceutisk Fabrik Novel raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these
IT1403083B1 (it) * 2010-10-25 2013-10-04 Fidia Farmaceutici Nuova forma polimorfa di raloxifene cloridrato

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4001426A (en) * 1974-10-17 1977-01-04 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents

Also Published As

Publication number Publication date
IL65379A0 (en) 1982-05-31
RO84584B (ro) 1984-09-30
PL235751A1 (es) 1982-11-22
FI821161A0 (fi) 1982-04-02
EP0062505A1 (en) 1982-10-13
ES511123A0 (es) 1983-02-16
DE3264853D1 (en) 1985-08-29
EP0062505B1 (en) 1985-07-24
GB2096608B (en) 1985-06-12
GR78364B (es) 1984-09-26
GB2096608A (en) 1982-10-20
FI821161L (fi) 1982-10-04
HU191084B (en) 1987-01-28
RO84584A (ro) 1984-07-17
PL130584B1 (en) 1984-08-31
PT74693B (en) 1985-01-08
DK151382A (da) 1982-10-04
BG37378A3 (en) 1985-05-15
PT74693A (en) 1982-05-01

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