ES8105388A1 - Un metodo para mantener, replicar y expresar por lo menos una porcion del genoma de un virus n.p. - Google Patents
Un metodo para mantener, replicar y expresar por lo menos una porcion del genoma de un virus n.p.Info
- Publication number
- ES8105388A1 ES8105388A1 ES491832A ES491832A ES8105388A1 ES 8105388 A1 ES8105388 A1 ES 8105388A1 ES 491832 A ES491832 A ES 491832A ES 491832 A ES491832 A ES 491832A ES 8105388 A1 ES8105388 A1 ES 8105388A1
- Authority
- ES
- Spain
- Prior art keywords
- production
- transfer vector
- vaccine
- dna transfer
- host transformed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title 1
- 230000000890 antigenic effect Effects 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 241000700721 Hepatitis B virus Species 0.000 abstract 1
- 206010019799 Hepatitis viral Diseases 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 238000007385 chemical modification Methods 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
Abstract
PROCEDIMIENTO PARA MANTENER, REPLICAR Y EXPRESAR UNA PORCION DEL GENOMA DE UN VIRUS NP. CONSTA DE LAS SIGUIENTES OPERACIONES: 1. AISLAR EL MATERIAL GENETICO, QUE COMPRENDE POR LO MENOS UNA PORCION DEL GENOMA DEL VIRUS NP O UN TRANSCRITO CADN DEL MISMO. 2. RECOMBINAR DICHO MATERIAL GENETICO CON UN VECTOR TRANSFERENTE DE ADN, FORMANDO UN VECTOR TRANSFERENTE RECOMBINANTE. 4. SELECCIONAR UNA CEPA DE CELULAS HUESPED CAPAD DE MANTENER, REPLICAR Y EXPRESAR EL VECTOR TRANSFERENTE RECOMBINANTE. 5. DESARROLLAR LA CELULA HUESPED SELECCIONADA EN CONDICIONES QUE FAVOREZCAN SU PROLIFERACION. EL VECTOR EMPLEADO ES PECO-63 Y EL HUESPED ES <<E. COLI>> HB-101. COMPRESION DE LA INUDCCION DE LAS ENFERMEDADES CRONICAS CAUSADAS TIPICAMENTE POR VIRUS NP.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4190979A | 1979-05-24 | 1979-05-24 | |
US10726779A | 1979-12-26 | 1979-12-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8105388A1 true ES8105388A1 (es) | 1981-05-16 |
ES491832A0 ES491832A0 (es) | 1981-05-16 |
Family
ID=26718684
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES491832A Granted ES491832A0 (es) | 1979-05-24 | 1980-05-23 | Un metodo para mantener, replicar y expresar por lo menos una porcion del genoma de un virus n.p. |
Country Status (11)
Country | Link |
---|---|
US (1) | US5436139A (es) |
EP (1) | EP0020251B1 (es) |
JP (2) | JPH0659221B2 (es) |
CA (1) | CA1341643C (es) |
DE (2) | DE3072205T2 (es) |
DK (1) | DK226680A (es) |
ES (1) | ES491832A0 (es) |
GR (1) | GR68524B (es) |
IE (1) | IE52036B1 (es) |
PT (1) | PT71296B (es) |
YU (1) | YU46343B (es) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2480779B2 (fr) * | 1979-08-30 | 1986-07-18 | Anvar | Vecteur contenant une sequence nucleotidique de l'antigene de surface du virus de l'hepatite b et procede de fabrication d'une molecule immunogene mettant en oeuvre ce vecteur |
US6297355B1 (en) | 1978-12-22 | 2001-10-02 | Biogen, Inc. | Polypeptides displaying HBV antigenicity or hbv antigen specificity |
YU44186B (en) * | 1978-12-22 | 1990-04-30 | Biogen Nv | Process for obtaining recombinant dnk molecules |
EP0182442B2 (en) * | 1978-12-22 | 1996-04-03 | Biogen, Inc. | Recombinant DNA molecules and their method of production |
US5196194A (en) * | 1979-05-24 | 1993-03-23 | The Regents Of The University Of California | Vaccines containing Hepatitis B S-protein |
US4342832A (en) * | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
US4249952A (en) * | 1980-03-03 | 1981-02-10 | Pennsylvania Engineering Corporation | Method for producing cement clinker from cement kiln waste dust |
FR2480780B1 (fr) * | 1980-04-22 | 1985-12-06 | Pasteur Institut | Procede de transformation de cellules, notamment eucaryotes, par un adn circulaire tel que celui du virus de l'hepatite b et preparations contenant les produits d'expression desdits adn |
DE3176404D1 (en) * | 1980-04-22 | 1987-10-08 | Pasteur Institut | Vaccine against viral hepatitis b, method and transformed eucaryotic cells for the preparation of this vaccine |
IL63224A (en) * | 1980-07-17 | 1985-05-31 | Scripps Clinic Res | Synthetic peptide specific antigenic determinant and method of manufacturing antigenic materials therefrom |
EP0062574A3 (en) * | 1981-03-31 | 1982-12-29 | The Regents Of The University Of California | Virus protein synthesis |
EP0068719A3 (en) * | 1981-06-16 | 1984-03-28 | Takeda Chemical Industries, Ltd. | Deoxyribonucleic acids, their production and use |
US4769238A (en) | 1981-08-04 | 1988-09-06 | The Regents Of The University Of California | Synthesis of human virus antigens by yeast |
EP0340806B1 (en) * | 1981-08-04 | 1995-05-31 | The Regents Of The University Of California | Synthesis of human virus antigens by yeast |
GR76274B (es) * | 1981-08-04 | 1984-08-04 | Univ California | |
NZ201705A (en) * | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
US4803164A (en) * | 1981-08-31 | 1989-02-07 | Genentech, Inc. | Preparation of hepatitis b surface antigen in yeast |
ZW18282A1 (en) | 1981-08-31 | 1983-03-23 | Genentech Inc | Preparation of polypeptides in vertebrate cell culture |
US4888170A (en) * | 1981-10-22 | 1989-12-19 | Research Corporation | Vaccines obtained from antigenic gene products of recombinant genes |
US4741901A (en) * | 1981-12-03 | 1988-05-03 | Genentech, Inc. | Preparation of polypeptides in vertebrate cell culture |
JPS58110600A (ja) * | 1981-12-25 | 1983-07-01 | Kyowa Hakko Kogyo Co Ltd | ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド |
US4460689A (en) * | 1982-04-15 | 1984-07-17 | Merck & Co., Inc. | DNA Cloning vector TG1, derivatives, and processes of making |
US4508826A (en) * | 1982-04-15 | 1985-04-02 | Merck & Co., Inc. | Bacteriophage DNA cloning vector TG1 and microorganisms containing TG1 |
JPS5980615A (ja) * | 1982-10-29 | 1984-05-10 | Takeda Chem Ind Ltd | Dnaおよびその用途 |
US4703009A (en) * | 1983-03-08 | 1987-10-27 | Merck & Co., Inc. | RDNA cloning vector pVE1, deletion and hybrid mutants and recombinant derivatives thereof products and processes |
US4820642A (en) * | 1983-04-04 | 1989-04-11 | The Regents Of The University Of California | Amplified expression vector |
US4859600A (en) * | 1983-04-25 | 1989-08-22 | Genentech, Inc. | Recombinant procaryotic cell containing correctly processed human growth hormone |
US4755465A (en) * | 1983-04-25 | 1988-07-05 | Genentech, Inc. | Secretion of correctly processed human growth hormone in E. coli and Pseudomonas |
JPS6078999A (ja) * | 1983-10-05 | 1985-05-04 | Chemo Sero Therapeut Res Inst | HBs抗原の精製方法 |
US5204096A (en) * | 1984-03-07 | 1993-04-20 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers |
US5324513A (en) * | 1984-03-07 | 1994-06-28 | Institut Pasteur | Composition useful for the fabrication of vaccines |
US5158769A (en) * | 1984-03-07 | 1992-10-27 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers |
EP0401941A3 (en) * | 1984-07-11 | 1991-04-17 | Takeda Chemical Industries, Ltd. | Hepatitis b virus surface antigen and production thereof |
DE3584866D1 (de) * | 1984-09-12 | 1992-01-23 | Chiron Corp | Hybridpartikel-immunogene. |
JPS61103895A (ja) * | 1984-10-26 | 1986-05-22 | Green Cross Corp:The | HBsAgの精製方法 |
EP0180012A1 (de) * | 1984-10-27 | 1986-05-07 | Wolfram H. Prof. Dr. Gerlich | Immunogene Polypeptidsequenz des Hepatitis B-Virus |
US7273695B1 (en) | 1984-10-31 | 2007-09-25 | Novartis Vaccines And Diagnostics, Inc. | HIV immunoassays using synthetic envelope polypeptides |
US7285271B1 (en) | 1984-10-31 | 2007-10-23 | Novartis Vaccines And Diagnostics, Inc. | Antigenic composition comprising an HIV gag or env polypeptide |
CA1341482C (en) | 1984-10-31 | 2005-05-10 | Paul A. Luciw | Process for preparing fragments of aids-associated retroviruses |
US7393949B1 (en) * | 1987-12-24 | 2008-07-01 | Novartis Vaccines And Diagnostics, Inc. | Human immunodeficiency virus (HIV) nucleotide sequences |
FI861417A0 (fi) * | 1985-04-15 | 1986-04-01 | Endotronics Inc | Hepatitis b ytantigen framstaelld med rekombinant-dna-teknik, vaccin, diagnostiskt medel och cellinjer samt foerfaranden foer framstaellning daerav. |
JPH089637B2 (ja) * | 1986-06-18 | 1996-01-31 | 財団法人阪大微生物病研究会 | B型肝炎ウイルス抗原とその製造法 |
AU1668788A (en) * | 1987-05-26 | 1988-12-01 | Wistar Institute, The | Method of vaccination for hepatitis b virus |
DE10299017I2 (de) * | 1987-06-22 | 2005-05-25 | Medeva Holdings Bv | Hepatitis-B-Oberfl{chenantigen enthaltendes Peptid. |
EP0338620A1 (en) * | 1988-04-18 | 1989-10-25 | Merck & Co. Inc. | Recovery of hepatitis B surface antigen |
US4953930A (en) * | 1989-03-15 | 1990-09-04 | Ramtech, Inc. | CPU socket supporting socket-to-socket optical communications |
EP0491077A1 (en) * | 1990-12-19 | 1992-06-24 | Medeva Holdings B.V. | A composition used as a therapeutic agent against chronic viral hepatic diseases |
US5928902A (en) * | 1992-02-27 | 1999-07-27 | Smithkline Beecham Biologicals (S.A.) | Hybrid protein between CS from plasmodium and HBsAg |
US5651568A (en) * | 1992-10-09 | 1997-07-29 | Gainsborough Hardware Industries, Limited | Privacy snib mechanism |
US6759193B2 (en) * | 1999-07-28 | 2004-07-06 | The Government Of The Republic Of Singapore | Detection of human hepatitis B virus surface antigen mutants by specific amplification and its application on gene chip |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2444713A1 (fr) * | 1978-12-18 | 1980-07-18 | Pasteur Institut | Procede de production d'un adn comprenant le genome du virus de l'hepatite b et vecteur le comportant |
FR2480779B2 (fr) * | 1979-08-30 | 1986-07-18 | Anvar | Vecteur contenant une sequence nucleotidique de l'antigene de surface du virus de l'hepatite b et procede de fabrication d'une molecule immunogene mettant en oeuvre ce vecteur |
YU44186B (en) * | 1978-12-22 | 1990-04-30 | Biogen Nv | Process for obtaining recombinant dnk molecules |
US5196194A (en) * | 1979-05-24 | 1993-03-23 | The Regents Of The University Of California | Vaccines containing Hepatitis B S-protein |
IL71991A (en) * | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
-
1980
- 1980-05-14 IE IE991/80A patent/IE52036B1/en not_active IP Right Cessation
- 1980-05-22 GR GR62032A patent/GR68524B/el unknown
- 1980-05-22 CA CA352501A patent/CA1341643C/en active Active
- 1980-05-23 ES ES491832A patent/ES491832A0/es active Granted
- 1980-05-23 DE DE8080400722T patent/DE3072205T2/de not_active Revoked
- 1980-05-23 YU YU140380A patent/YU46343B/sh unknown
- 1980-05-23 DK DK226680A patent/DK226680A/da not_active Application Discontinuation
- 1980-05-23 EP EP80400722A patent/EP0020251B1/en not_active Revoked
- 1980-05-23 DE DE198080400722T patent/DE20251T1/de active Pending
- 1980-05-23 PT PT71296A patent/PT71296B/pt unknown
- 1980-05-24 JP JP55069516A patent/JPH0659221B2/ja not_active Expired - Lifetime
-
1988
- 1988-08-09 JP JP63198756A patent/JP2543751B2/ja not_active Expired - Lifetime
-
1993
- 1993-07-08 US US08/089,993 patent/US5436139A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH02450A (ja) | 1990-01-05 |
DE3072205D1 (de) | 1993-02-25 |
DK226680A (da) | 1980-11-25 |
GR68524B (es) | 1982-01-11 |
PT71296B (en) | 1981-09-21 |
CA1341643C (en) | 2023-02-28 |
IE52036B1 (en) | 1987-05-27 |
EP0020251A3 (en) | 1981-05-20 |
YU46343B (sh) | 1993-10-20 |
YU140380A (en) | 1988-10-31 |
DE3072205T2 (de) | 1993-08-05 |
JPS5663995A (en) | 1981-05-30 |
JP2543751B2 (ja) | 1996-10-16 |
EP0020251B1 (en) | 1993-01-13 |
DE20251T1 (de) | 1986-02-27 |
US5436139A (en) | 1995-07-25 |
JPH0659221B2 (ja) | 1994-08-10 |
PT71296A (en) | 1980-06-01 |
EP0020251A2 (en) | 1980-12-10 |
IE800991L (en) | 1980-11-24 |
ES491832A0 (es) | 1981-05-16 |
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