ES8103976A1 - Un metodo de producir proteinas de interferon humano de for-ma le - Google Patents

Un metodo de producir proteinas de interferon humano de for-ma le

Info

Publication number
ES8103976A1
ES8103976A1 ES490697A ES490697A ES8103976A1 ES 8103976 A1 ES8103976 A1 ES 8103976A1 ES 490697 A ES490697 A ES 490697A ES 490697 A ES490697 A ES 490697A ES 8103976 A1 ES8103976 A1 ES 8103976A1
Authority
ES
Spain
Prior art keywords
interferon
species
affinity chromatography
interferon proteins
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES490697A
Other languages
English (en)
Other versions
ES490697A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfred Benzon AS
Original Assignee
Alfred Benzon AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27220922&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8103976(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alfred Benzon AS filed Critical Alfred Benzon AS
Publication of ES490697A0 publication Critical patent/ES490697A0/es
Publication of ES8103976A1 publication Critical patent/ES8103976A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/249—Interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

METODO PARA LA OBTENCION DE PROTEINAS DE INTERFERON HUMANO DE FORMA LE Y ANTIINTERFERON ESTRICTAMENTE ESPECIFICO PARA LAS ESPECIES ACTIVAS; FORMULACION DE UNA PREPARACION QUE CONTIENE LA PROTEINA O PROTEINAS DE DICHO INTERFERON. EL METODO CONSISTE EN APLICAR UNA DISOLUCION ACUOSA, QUE CONTIENE PROTEINAS DE INTERFERON HUMANO DE FORMA LE CON UNA ACTIVIDAD ESPECIFICA DE 50.000-100.000 UIF POR MG, TAMPONADA A UN PH DE 6,5-8, CON UNA CONCENTRACION IONICA QUE NO EXCEDA SUSTANCIALMENTE DE LA DE UNA DISOLUCION REGULADORA DE FOSFATO DE 10-100 MM Y OPCIONALMENTE EN UN DISOLVENTE REGULADORA DE AGUA, SOBRE UN LIGAMENTO INMOVILIZADO EN UN MATRIZ CAPAZ DE FIJAR EL INTERFERON, Y POSTERIORMENTE ELUIR EL INTERFERON. TAMBIEN SE PUEDE APLICAR UN METODO BASADO EN EL CULTIVO DE UN MICROORGANISMO QUE LLEVA CODIFICACION ADN PARA LA PRODUCCION DE PROTEINAS DE INTERFERON DE FORMA LE O PROTEINAS QUE TIENEN SUS DETERMINANTES INMUNOLOGICOS SIGNIFICATIVOS. TIENEN APLICACION PARA EFECTO PROFILACTICO, TERAPEUTICO O DE INMUNIZACION, CON ACTIVIDAD ANTIVIRICA Y ANTITUMORAL.
ES490697A 1979-04-20 1980-04-18 Un metodo de producir proteinas de interferon humano de for-ma le Expired ES8103976A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK164579 1979-04-20
DK79180 1980-02-22
DK148480 1980-04-02

Publications (2)

Publication Number Publication Date
ES490697A0 ES490697A0 (es) 1981-04-16
ES8103976A1 true ES8103976A1 (es) 1981-04-16

Family

ID=27220922

Family Applications (1)

Application Number Title Priority Date Filing Date
ES490697A Expired ES8103976A1 (es) 1979-04-20 1980-04-18 Un metodo de producir proteinas de interferon humano de for-ma le

Country Status (15)

Country Link
EP (2) EP0091543B1 (es)
JP (2) JPH0742317B2 (es)
AU (1) AU539494B2 (es)
CA (1) CA1168151A (es)
DE (2) DE3072134D1 (es)
ES (1) ES8103976A1 (es)
FI (1) FI77877C (es)
HK (1) HK22792A (es)
IE (1) IE55791B1 (es)
IL (1) IL59880A (es)
NO (1) NO165961C (es)
NZ (1) NZ193487A (es)
PT (1) PT71111A (es)
SG (1) SG92591G (es)
WO (1) WO1980002229A1 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
US4530901A (en) * 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides
US6835557B1 (en) 1980-01-08 2004-12-28 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing human interferon-like polypeptides
DE3005843A1 (de) * 1980-02-16 1981-09-10 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
JP2687995B2 (ja) 1980-04-03 1997-12-08 バイオゲン インコーポレイテッド Ｄｎａ配列、組替えｄｎａ分子およびヒト繊維芽細胞インターフェロン様ポリペプチドの製造方法
EP0050129B1 (en) * 1980-04-11 1992-03-18 Celltech Limited Monoclonal antibody
CH657141A5 (de) * 1980-07-01 1986-08-15 Hoffmann La Roche Dns-sequenzen, rekombinante expressionsvektoren zur mikrobiellen herstellung von human-leukozyten-interferonen und transformierte mikroorganismen.
FR2492842A1 (fr) * 1980-10-24 1982-04-30 Centre Nat Rech Scient Hybride cellulaire produisant un anticorps specifique de l'interferon leucocytaire humain et procede de formation d'hybrides cellulaires producteurs d'anticorps specifiques de l'interferon humain
JPS58500037A (ja) * 1980-11-07 1983-01-06 セルテク　リミテツド インタ−フェロンの検定法
WO1982001773A1 (en) * 1980-11-07 1982-05-27 Secher David S Assay for interferon
AU561649B2 (en) * 1981-02-27 1987-05-14 F. Hoffmann-La Roche Ag Antibodies to proteins
EP0062971B1 (en) * 1981-03-27 1990-03-07 Imperial Chemical Industries Plc Genetically modified microorganisms
IL65475A0 (en) * 1981-04-17 1982-07-30 Meloy Lab Production of immune interferon and its mrna
EP0085693A1 (en) * 1981-08-14 1983-08-17 A/S Alfred Benzon Subjects relating to human inteferon-alpha subtype proteins and corresponding antibodies
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
JPS58201794A (ja) * 1982-05-17 1983-11-24 Toray Ind Inc ヒトインターフェロンβの濃縮精製法
US5702699A (en) * 1982-09-23 1997-12-30 Cetus Corporation Process for the recovery of lipophilic proteins
US4992271A (en) * 1982-09-23 1991-02-12 Cetus Corporation Formulation for lipophilic IL-2 proteins
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
US4534906A (en) * 1982-11-01 1985-08-13 Genentech, Inc. Removal of impurities from human leukocyte interferon preparations
DE3306060A1 (de) * 1983-02-22 1984-08-23 Boehringer Ingelheim International GmbH, 6507 Ingelheim Neue immunglobulin-produzierende hybridzellinien, deren verwendung und verfahren zu deren herstellung
DE3515336C2 (de) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Verfahren zur Herstellung und Reinigung von â-Interferon
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
EP0490233A1 (de) * 1986-03-10 1992-06-17 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Monoclonale Antikörper gegen BgIII-Hybridinterferone, deren Verwendung und Verfahren zu ihrer Herstellung
DE3607835A1 (de) * 1986-03-10 1987-09-24 Boehringer Ingelheim Int Hybridinterferone, deren verwendung als arzneimittel und als zwischenprodukte zur herstellung von antikoerpern und deren verwendung sowie verfahren zu ihrer herstellung
DE3633323A1 (de) * 1986-10-01 1988-04-07 Boehringer Ingelheim Int Neue monoklonale antikoerper gegen ifn-omega, verfahren zu ihrer herstellung und deren verwendung zur reinigung sowie zum nachweis von ifn-omega
SE468251B (sv) 1989-06-20 1992-11-30 Bionative Ab Reningsprocess foer interferon
US5391713A (en) * 1989-06-20 1995-02-21 Bionative Ab Interferon purification process
US5676942A (en) * 1992-02-10 1997-10-14 Interferon Sciences, Inc. Composition containing human alpha interferon species proteins and method for use thereof
DE69324671D1 (de) * 1992-02-10 1999-06-02 Interferon Sciences Inc Verbesserte alpha-interferon-zusammensetzung und verfahren zu ihrer herstellung aus leukocyten des menschlichen peripheren blute
JP4706093B2 (ja) * 2000-09-25 2011-06-22 富士レビオ株式会社 パルボウイルスの除去方法及び精製方法
US7087726B2 (en) 2001-02-22 2006-08-08 Genentech, Inc. Anti-interferon-α antibodies

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2351665A1 (fr) * 1976-05-21 1977-12-16 Elf Aquitaine Procede de purification de preparations possedant notamment une activite interferon, preparations purifiees ainsi obtenues et leur application en tant que medicament
NL7703281A (nl) * 1977-03-25 1978-09-27 Stichting Rega V Z W Werkwijze voor het bereiden van interferon.
FR2389380B1 (es) * 1977-05-02 1980-02-29 Anvar
IN150740B (es) * 1978-11-24 1982-12-04 Hoffmann La Roche
DK170236B1 (da) * 1980-01-08 1995-07-10 Biogen Inc Rekombinante DNA-molekyler, fremgangsmåde til fremstilling af et polypeptid af IFN-alfa typen og fremgangsmåde til udvælgelse af DNA-sekvenser, der koder for polypeptider af IFN-alfa typen
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain

Also Published As

Publication number Publication date
JPS56500536A (es) 1981-04-23
JPH0794480B2 (ja) 1995-10-11
AU539494B2 (en) 1984-10-04
EP0091543A1 (en) 1983-10-19
DE3072134D1 (en) 1988-12-29
NZ193487A (en) 1983-07-15
NO165961B (no) 1991-01-28
ES490697A0 (es) 1981-04-16
SG92591G (en) 1993-02-19
AU5759980A (en) 1980-10-23
JPH02198A (ja) 1990-01-05
FI77877C (fi) 1989-05-10
CA1168151A (en) 1984-05-29
IE55791B1 (en) 1991-01-16
DE91543T1 (de) 1984-12-20
HK22792A (en) 1992-04-03
EP0091543B1 (en) 1989-06-14
IL59880A0 (en) 1980-06-30
PT71111A (en) 1980-05-01
WO1980002229A1 (en) 1980-10-30
FI77877B (fi) 1989-01-31
EP0018218B1 (en) 1988-11-23
NO801133L (no) 1980-12-18
JPH0742317B2 (ja) 1995-05-10
IE800796L (en) 1980-10-20
EP0018218A1 (en) 1980-10-29
IL59880A (en) 1984-03-30
FI801215A (fi) 1980-10-21
NO165961C (no) 1991-05-15

Similar Documents

Publication Publication Date Title
ES8103976A1 (es) Un metodo de producir proteinas de interferon humano de for-ma le
UA29494C2 (uk) Гуманізовані антитіла, способи їх продукування, спосіб лікування хвороби крона, спосіб лікування розсіяного склерозу, фармацевтична композиція
IL58759A (en) Process for purifying proteins,pure and homogeneous interferon species obtained thereby and pharmaceutical compositions containing them
BR8301918A (pt) Proteina,sequencia de dna,veiculo de expressao replicavel,microorganismo ou cultura celular,plasmideo,composicao,cultura de celulas,utilizacao de tal proteina,processo de expressao,processo para producao de um veiculo de expressao e processo para preparacao de uma proteina uroquinase
DE69702705T2 (de) Kondensierte pyrrolo(2,3-c) carbazole-6-one die die aktivität von gamma interferon potenzieren
ATE161013T1 (de) Verfahren zum reinigen von 20 cs)-camptothecin
ATE246248T1 (de) Anti-hiv-proteine gap31, dap30 und dap32, die sie kodierende dna und ihre therapeutische nutzung
DE69333745D1 (de) Löslicher komplex morphogener proteine und zusammensetzungen davon
DE3061854D1 (en) Process for the preparation of interferon and culture medium composition used in it
KR860002526A (ko) 단백질의 상호 분리 방법
ES8200560A1 (es) Un procedimiento para producir interferon de fibroblasto hu-mano
FR2560212B1 (fr) Anticorps monoclonaux contre l'interferon a2 et hybridomes produisant de tels anticorps
ATE80802T1 (de) Verfahren und zusammensetzung zur behandlung von krebs und nichtmalignen tumoren.
KR950700684A (ko) 시클릭 항-종양 촉진제 화합물, 그의 조성물, 제조 방법 및 용도(Cyclic Anti-Tumor Promoter Compounds, Compositions and Methods for Production and Use)
DE3687995T2 (de) Verfahren zur reinigung von interferon und so hergestellte zusammensetzung.
FR2556721B1 (fr) Nouveaux derives de o-mercaptopropanamide d'o amino-acides, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
ES370345A1 (es) Un procedimiento para fabricar una preparacion inyectable de insulina.
FI92716C (fi) Uudet monoklonaaliset vasta-aineet IFN-omegalle, niiden valmistusmenetelmät ja niiden käyttö IFN-omegan puhdistamiseen ja osoittamiseen
ES8800275A1 (es) Procedimiento para la preparacion de nuevos antigenos nativos pseudomonas-flagella (h)
OA05141A (fr) Nouveaux dérivés de l'Oxathiinno (1,4) (2,3-C) pyrolle, leur préparation et les compositions qui les contiennent.
ATE33842T1 (de) Immuninterferon und verfahren zu seiner reinigung.
FR2555577B1 (fr) Nouveaux derives de peptides, leur procede de preparation et leur emploi comme reactif biologique
DE69836226D1 (de) Ifn rezeptor 1 bindende proteine, dafür kodierende dna und verfahren zur regulierung der zellulären antwort auf interferone
IT1178489B (it) Vettore clonante, procedimento per la sua costruzione e procedimento di concentrazione e di purificazione di proteine prodotte, formate dal vettore clonante
IE41485L (en) Purification of protein conjugates

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990201