ES541630A0 - Procedimiento para preparar 14-hidroxi-n-etoxicarbonil-nor- codeinona - Google Patents

Procedimiento para preparar 14-hidroxi-n-etoxicarbonil-nor- codeinona

Info

Publication number
ES541630A0
ES541630A0 ES541630A ES541630A ES541630A0 ES 541630 A0 ES541630 A0 ES 541630A0 ES 541630 A ES541630 A ES 541630A ES 541630 A ES541630 A ES 541630A ES 541630 A0 ES541630 A0 ES 541630A0
Authority
ES
Spain
Prior art keywords
norcodeinone
ethoxycarbonyl
contacting
sub
basic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES541630A
Other languages
English (en)
Other versions
ES8607306A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of ES8607306A1 publication Critical patent/ES8607306A1/es
Publication of ES541630A0 publication Critical patent/ES541630A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
  • Noodles (AREA)
  • Thermistors And Varistors (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES541630A 1984-03-27 1985-03-27 Procedimiento para preparar 14-hidroxi-n-etoxicarbonil-nor- codeinona Expired ES8607306A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/593,752 US4639520A (en) 1984-03-27 1984-03-27 Preparation of 14-hydroxy-N-ethoxy-carbonyl-norcodeinone

Publications (2)

Publication Number Publication Date
ES8607306A1 ES8607306A1 (es) 1986-05-16
ES541630A0 true ES541630A0 (es) 1986-05-16

Family

ID=24376012

Family Applications (2)

Application Number Title Priority Date Filing Date
ES541630A Expired ES8607306A1 (es) 1984-03-27 1985-03-27 Procedimiento para preparar 14-hidroxi-n-etoxicarbonil-nor- codeinona
ES550731A Expired ES8705447A1 (es) 1984-03-27 1986-01-08 Procedimiento para preparar noroximorfona a partir de co- deina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES550731A Expired ES8705447A1 (es) 1984-03-27 1986-01-08 Procedimiento para preparar noroximorfona a partir de co- deina

Country Status (9)

Country Link
US (1) US4639520A (es)
EP (1) EP0159823B1 (es)
JP (1) JPH0651702B2 (es)
AT (1) ATE45358T1 (es)
DE (1) DE3572172D1 (es)
ES (2) ES8607306A1 (es)
FR (1) FR2566777B1 (es)
IT (1) IT1184058B (es)
NO (1) NO161975C (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
ES2129395T3 (es) * 1989-10-16 1999-06-16 Us Health Sintesis total de enantiomeros de nortebaina, normorfina, noroximorfona y sus derivados a traves de productos intermedios n-nor.
TWI483944B (zh) 2004-03-30 2015-05-11 Euro Celtique Sa 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
EP1893616B1 (en) * 2005-06-16 2010-12-29 Mallinckrodt, Inc. A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
JP2010522189A (ja) * 2007-03-23 2010-07-01 マリンクロッド・インコーポレイテッド オリパビンからのオキシモルホンの改善された調製
WO2008130553A1 (en) * 2007-04-16 2008-10-30 Mallinckrodt Inc. Novel opiate reduction utilizing catalytic hydrogen transfer reaction
CA2726220C (en) * 2008-05-27 2017-03-28 Mallinckrodt Inc. Processes and compounds for the preparation of normorphinans
CA2936749C (en) 2010-06-11 2019-07-09 Joshua R. Giguere Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
EP2580218B1 (en) 2010-06-11 2015-02-25 Rhodes Technologies Process for n-dealkylation of tertiary amines
DE102012108266A1 (de) 2012-09-05 2014-03-06 Aesculap Ag Chirurgisches, Drehmoment übertragendes Instrument einschließlich zugehöriges Werkzeug

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2772270A (en) * 1954-10-21 1956-11-27 M J Lewenstein 14-hydroxymorphinone and 8, 14-dihydroxydihydromorphinone
DE1938219A1 (de) * 1968-07-26 1970-02-12 Sankyo Co Verfahren zur Herstellung von 14-Hydroxy-normorphinonderivaten
US4472253A (en) * 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative

Also Published As

Publication number Publication date
NO851217L (no) 1985-09-30
ES8705447A1 (es) 1987-05-01
US4639520A (en) 1987-01-27
ES550731A0 (es) 1987-05-01
FR2566777B1 (fr) 1989-09-29
EP0159823B1 (en) 1989-08-09
JPH0651702B2 (ja) 1994-07-06
NO161975C (no) 1989-10-18
ES8607306A1 (es) 1986-05-16
IT1184058B (it) 1987-10-22
EP0159823A1 (en) 1985-10-30
JPS60218392A (ja) 1985-11-01
FR2566777A1 (fr) 1986-01-03
IT8567298A0 (it) 1985-03-26
ATE45358T1 (de) 1989-08-15
DE3572172D1 (en) 1989-09-14
NO161975B (no) 1989-07-10
IT8567298A1 (it) 1986-09-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050225