ES8607306A1 - Procedimiento para preparar 14-hidroxi-n-etoxicarbonil-nor- codeinona - Google Patents

Procedimiento para preparar 14-hidroxi-n-etoxicarbonil-nor- codeinona

Info

Publication number
ES8607306A1
ES8607306A1 ES541630A ES541630A ES8607306A1 ES 8607306 A1 ES8607306 A1 ES 8607306A1 ES 541630 A ES541630 A ES 541630A ES 541630 A ES541630 A ES 541630A ES 8607306 A1 ES8607306 A1 ES 8607306A1
Authority
ES
Spain
Prior art keywords
norcodeinone
ethoxycarbonyl
contacting
basic
reaction conditions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541630A
Other languages
English (en)
Other versions
ES541630A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of ES8607306A1 publication Critical patent/ES8607306A1/es
Publication of ES541630A0 publication Critical patent/ES541630A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
  • Noodles (AREA)
  • Thermistors And Varistors (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE N-ETOXICARBONIL-14-B-HIDROXINORCODEINONA. CONSISTE EN LA REACCION DEL ENOLACETATO DE N-ETOXICARBONIL-NORCODINONA CON UN PEROXI-ACIDO MONOBASICO, AROMATICO O ALIFATICO QUE PERMITE LA SUSTITUCION DE UN GRUPO OH EN LA POSICION 14 DEL ENOACETATO DE NORCODEINONA. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO POLAR INERTE EN EL MEDIO DE REACCION, EN PRESENCIA DE UN ACIDO MODERADAMENTE FUERTE DE PKA ENTRE 0,3 Y 3,5, EN AUSENCIA SUSTANCIAL DE AGUA, A UNA TEMPERATURA COMPRENDIDA ENTRE 10JC Y 100JC. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS COMO AGENTE ANALGESICO Y ANTAGONISTA NARCOTICO.
ES541630A 1984-03-27 1985-03-27 Procedimiento para preparar 14-hidroxi-n-etoxicarbonil-nor- codeinona Expired ES8607306A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/593,752 US4639520A (en) 1984-03-27 1984-03-27 Preparation of 14-hydroxy-N-ethoxy-carbonyl-norcodeinone

Publications (2)

Publication Number Publication Date
ES8607306A1 true ES8607306A1 (es) 1986-05-16
ES541630A0 ES541630A0 (es) 1986-05-16

Family

ID=24376012

Family Applications (2)

Application Number Title Priority Date Filing Date
ES541630A Expired ES8607306A1 (es) 1984-03-27 1985-03-27 Procedimiento para preparar 14-hidroxi-n-etoxicarbonil-nor- codeinona
ES550731A Expired ES8705447A1 (es) 1984-03-27 1986-01-08 Procedimiento para preparar noroximorfona a partir de co- deina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES550731A Expired ES8705447A1 (es) 1984-03-27 1986-01-08 Procedimiento para preparar noroximorfona a partir de co- deina

Country Status (9)

Country Link
US (1) US4639520A (es)
EP (1) EP0159823B1 (es)
JP (1) JPH0651702B2 (es)
AT (1) ATE45358T1 (es)
DE (1) DE3572172D1 (es)
ES (2) ES8607306A1 (es)
FR (1) FR2566777B1 (es)
IT (1) IT1184058B (es)
NO (1) NO161975C (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7674800B2 (en) 2004-03-30 2010-03-09 Purdue Pharma L.P. Oxycodone hydrochloride having less than 25 PPM 14-hydroxycodeinone

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
ATE178329T1 (de) * 1989-10-16 1999-04-15 Us Health Totale synthese von northebain-, normorphin-, noroxymorphon-enantiomeren und -derivaten via n- nor-zwischenverbindungen
AU2006259780B2 (en) * 2005-06-16 2012-04-12 SpecGx LLC A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
CA2681740A1 (en) * 2007-03-23 2008-10-02 Mallinckrodt Inc. Improved preparation of oxymorphone from oripavine
CA2684458A1 (en) * 2007-04-16 2008-10-30 Mallinckrodt Inc. Novel opiate reduction utilizing catalytic hydrogen transfer reaction
US8148528B2 (en) * 2008-05-27 2012-04-03 Mallinckrodt Llc Processes and compounds for the preparation of normorphinans
ES2645725T3 (es) 2010-06-11 2017-12-07 Rhodes Technologies Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos
EP2580218B1 (en) 2010-06-11 2015-02-25 Rhodes Technologies Process for n-dealkylation of tertiary amines
DE102012108266A1 (de) 2012-09-05 2014-03-06 Aesculap Ag Chirurgisches, Drehmoment übertragendes Instrument einschließlich zugehöriges Werkzeug

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2772270A (en) * 1954-10-21 1956-11-27 M J Lewenstein 14-hydroxymorphinone and 8, 14-dihydroxydihydromorphinone
DE1938219A1 (de) * 1968-07-26 1970-02-12 Sankyo Co Verfahren zur Herstellung von 14-Hydroxy-normorphinonderivaten
US4472253A (en) * 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7674800B2 (en) 2004-03-30 2010-03-09 Purdue Pharma L.P. Oxycodone hydrochloride having less than 25 PPM 14-hydroxycodeinone
US7674799B2 (en) 2004-03-30 2010-03-09 Purdue Pharma L.P. Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone
US7674798B2 (en) 2004-03-30 2010-03-09 Purdue Pharma L.P. Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone
US7683072B2 (en) 2004-03-30 2010-03-23 Purdue Pharma L.P. Oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone
US8822687B2 (en) 2004-03-30 2014-09-02 Purdue Pharma L.P. 8a,14-dihydroxy-7,8-dihydrocodeinone
US9073933B2 (en) 2004-03-30 2015-07-07 Purdue Pharma L.P. Oxycodone hydrochloride having less than 25 PPM 14-hydroxycodeinone
US9522919B2 (en) 2004-03-30 2016-12-20 Purdue Pharma L.P. Oxycodone compositions
US9777011B2 (en) 2004-03-30 2017-10-03 Purdue Pharma L.P. Process for preparing oxycodone compositions
US10259819B2 (en) 2004-03-30 2019-04-16 Purdue Pharma L.P. Process for preparing oxycodone compositions
US10407434B2 (en) 2004-03-30 2019-09-10 Purdue Pharma L.P. Process for preparing oxycodone compositions
US10689389B2 (en) 2004-03-30 2020-06-23 Purdue Pharma L.P. Process for preparing oxycodone compositions
US10696684B2 (en) 2004-03-30 2020-06-30 Purdue Pharma L.P. Process for preparing oxycodone hydrochloride having less than 25 PPM 14-hydroxycodeinone
US11236098B2 (en) 2004-03-30 2022-02-01 Purdue Pharma L.P. Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone
US11384091B2 (en) 2004-03-30 2022-07-12 Purdue Pharma L.P. Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone
US12060361B2 (en) 2004-03-30 2024-08-13 Purdue Pharma L.P. Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone

Also Published As

Publication number Publication date
NO161975C (no) 1989-10-18
NO161975B (no) 1989-07-10
JPS60218392A (ja) 1985-11-01
US4639520A (en) 1987-01-27
ES550731A0 (es) 1987-05-01
EP0159823A1 (en) 1985-10-30
JPH0651702B2 (ja) 1994-07-06
ES8705447A1 (es) 1987-05-01
IT8567298A1 (it) 1986-09-26
EP0159823B1 (en) 1989-08-09
NO851217L (no) 1985-09-30
DE3572172D1 (en) 1989-09-14
IT1184058B (it) 1987-10-22
ES541630A0 (es) 1986-05-16
FR2566777B1 (fr) 1989-09-29
IT8567298A0 (it) 1985-03-26
FR2566777A1 (fr) 1986-01-03
ATE45358T1 (de) 1989-08-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050225