ATE45358T1 - Herstellung von 14-hydroxy-n-ethoxycarbonylnorcodeinon. - Google Patents

Herstellung von 14-hydroxy-n-ethoxycarbonylnorcodeinon.

Info

Publication number
ATE45358T1
ATE45358T1 AT85302102T AT85302102T ATE45358T1 AT E45358 T1 ATE45358 T1 AT E45358T1 AT 85302102 T AT85302102 T AT 85302102T AT 85302102 T AT85302102 T AT 85302102T AT E45358 T1 ATE45358 T1 AT E45358T1
Authority
AT
Austria
Prior art keywords
norcodeinone
ethoxycarbonyl
contacting
sub
basic
Prior art date
Application number
AT85302102T
Other languages
English (en)
Inventor
Frank Kavka
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE45358T1 publication Critical patent/ATE45358T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Noodles (AREA)
  • Thermistors And Varistors (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT85302102T 1984-03-27 1985-03-26 Herstellung von 14-hydroxy-n-ethoxycarbonylnorcodeinon. ATE45358T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/593,752 US4639520A (en) 1984-03-27 1984-03-27 Preparation of 14-hydroxy-N-ethoxy-carbonyl-norcodeinone
EP85302102A EP0159823B1 (de) 1984-03-27 1985-03-26 Herstellung von 14-Hydroxy-N-ethoxycarbonyl-norcodeinon

Publications (1)

Publication Number Publication Date
ATE45358T1 true ATE45358T1 (de) 1989-08-15

Family

ID=24376012

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85302102T ATE45358T1 (de) 1984-03-27 1985-03-26 Herstellung von 14-hydroxy-n-ethoxycarbonylnorcodeinon.

Country Status (9)

Country Link
US (1) US4639520A (de)
EP (1) EP0159823B1 (de)
JP (1) JPH0651702B2 (de)
AT (1) ATE45358T1 (de)
DE (1) DE3572172D1 (de)
ES (2) ES8607306A1 (de)
FR (1) FR2566777B1 (de)
IT (1) IT1184058B (de)
NO (1) NO161975C (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
JP2694156B2 (ja) * 1989-10-16 1997-12-24 アメリカ合衆国 Ｎ−ノル中間体を介するノルテバイン、ノルモルフィン、ノルオキシモルフォン鏡像異性体の全合成
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
TWI365880B (en) 2004-03-30 2012-06-11 Euro Celtique Sa Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
EP1893616B1 (de) * 2005-06-16 2010-12-29 Mallinckrodt, Inc. Synthetische route zu 14-hydroxylopiaten über 1-halogenthebain oder analoga
US8217175B2 (en) * 2007-03-23 2012-07-10 Mallinckrodt Llc Preparation of oxymorphone from oripavine
ES2423180T3 (es) * 2007-04-16 2013-09-18 Mallinckrodt Llc Nueva reducción de opiáceos mediante reacción de transferencia de hidrógeno catalítica
ES2549904T3 (es) * 2008-05-27 2015-11-03 Mallinckrodt Llc Procesos y compuestos para la preparación de normorfinanos
TWI471289B (zh) 2010-06-11 2015-02-01 Rhodes Technologies 使三級胺進行ｎ－脫烷反應之方法
JP5736040B2 (ja) 2010-06-11 2015-06-17 ローズ テクノロジーズ Ｎ−アリル化合物の調製のための遷移金属触媒プロセスおよびその使用
DE102012108266A1 (de) 2012-09-05 2014-03-06 Aesculap Ag Chirurgisches, Drehmoment übertragendes Instrument einschließlich zugehöriges Werkzeug

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2772270A (en) * 1954-10-21 1956-11-27 M J Lewenstein 14-hydroxymorphinone and 8, 14-dihydroxydihydromorphinone
DE1938219A1 (de) * 1968-07-26 1970-02-12 Sankyo Co Verfahren zur Herstellung von 14-Hydroxy-normorphinonderivaten
US4472253A (en) * 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative

Also Published As

Publication number Publication date
FR2566777A1 (fr) 1986-01-03
JPH0651702B2 (ja) 1994-07-06
JPS60218392A (ja) 1985-11-01
ES550731A0 (es) 1987-05-01
ES541630A0 (es) 1986-05-16
EP0159823A1 (de) 1985-10-30
NO161975B (no) 1989-07-10
ES8607306A1 (es) 1986-05-16
US4639520A (en) 1987-01-27
NO851217L (no) 1985-09-30
NO161975C (no) 1989-10-18
IT8567298A1 (it) 1986-09-26
EP0159823B1 (de) 1989-08-09
IT8567298A0 (it) 1985-03-26
IT1184058B (it) 1987-10-22
DE3572172D1 (en) 1989-09-14
ES8705447A1 (es) 1987-05-01
FR2566777B1 (fr) 1989-09-29

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time