NO161975C - Fremgangsmaate for fremstilling av n-etoksykarbonyl-14-bhydroksynorkodeinon. - Google Patents

Fremgangsmaate for fremstilling av n-etoksykarbonyl-14-bhydroksynorkodeinon.

Info

Publication number
NO161975C
NO161975C NO851217A NO851217A NO161975C NO 161975 C NO161975 C NO 161975C NO 851217 A NO851217 A NO 851217A NO 851217 A NO851217 A NO 851217A NO 161975 C NO161975 C NO 161975C
Authority
NO
Norway
Prior art keywords
ethoxycarbonyl
norcodeinone
contacting
sub
basic
Prior art date
Application number
NO851217A
Other languages
English (en)
Other versions
NO851217L (no
NO161975B (no
Inventor
Frank Kavka
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of NO851217L publication Critical patent/NO851217L/no
Publication of NO161975B publication Critical patent/NO161975B/no
Publication of NO161975C publication Critical patent/NO161975C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Noodles (AREA)
  • Thermistors And Varistors (AREA)
  • Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
NO851217A 1984-03-27 1985-03-26 Fremgangsmaate for fremstilling av n-etoksykarbonyl-14-bhydroksynorkodeinon. NO161975C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/593,752 US4639520A (en) 1984-03-27 1984-03-27 Preparation of 14-hydroxy-N-ethoxy-carbonyl-norcodeinone

Publications (3)

Publication Number Publication Date
NO851217L NO851217L (no) 1985-09-30
NO161975B NO161975B (no) 1989-07-10
NO161975C true NO161975C (no) 1989-10-18

Family

ID=24376012

Family Applications (1)

Application Number Title Priority Date Filing Date
NO851217A NO161975C (no) 1984-03-27 1985-03-26 Fremgangsmaate for fremstilling av n-etoksykarbonyl-14-bhydroksynorkodeinon.

Country Status (9)

Country Link
US (1) US4639520A (no)
EP (1) EP0159823B1 (no)
JP (1) JPH0651702B2 (no)
AT (1) ATE45358T1 (no)
DE (1) DE3572172D1 (no)
ES (2) ES8607306A1 (no)
FR (1) FR2566777B1 (no)
IT (1) IT1184058B (no)
NO (1) NO161975C (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
DE69033035T2 (de) * 1989-10-16 1999-08-05 Us Health Totale synthese von northebain-, normorphin-, noroxymorphon-enantiomeren und -derivaten via n-nor-zwischenverbindungen
TWI365880B (en) * 2004-03-30 2012-06-11 Euro Celtique Sa Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
CN101198612A (zh) * 2005-06-16 2008-06-11 马林克罗特公司 通过1-卤代-蒂巴因或类似物制备14-羟基阿片类的合成路线
WO2008118654A1 (en) * 2007-03-23 2008-10-02 Mallinckrodt Inc. Improved preparation of oxymorphone from oripavine
JP5373764B2 (ja) * 2007-04-16 2013-12-18 マリンクロッド エルエルシー 触媒性水素転移反応を使用する新規なオピエート還元
JP6027315B2 (ja) * 2008-05-27 2016-11-16 マリンクロッド エルエルシー ノルモルフィナンの調製のための方法および化合物
EP2580218B1 (en) 2010-06-11 2015-02-25 Rhodes Technologies Process for n-dealkylation of tertiary amines
EP2995614B8 (en) 2010-06-11 2018-03-28 Rhodes Technologies Inc. Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
DE102012108266A1 (de) 2012-09-05 2014-03-06 Aesculap Ag Chirurgisches, Drehmoment übertragendes Instrument einschließlich zugehöriges Werkzeug

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2772270A (en) * 1954-10-21 1956-11-27 M J Lewenstein 14-hydroxymorphinone and 8, 14-dihydroxydihydromorphinone
DE1938219A1 (de) * 1968-07-26 1970-02-12 Sankyo Co Verfahren zur Herstellung von 14-Hydroxy-normorphinonderivaten
US4472253A (en) * 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative

Also Published As

Publication number Publication date
JPH0651702B2 (ja) 1994-07-06
NO851217L (no) 1985-09-30
ATE45358T1 (de) 1989-08-15
NO161975B (no) 1989-07-10
FR2566777B1 (fr) 1989-09-29
US4639520A (en) 1987-01-27
IT8567298A0 (it) 1985-03-26
ES550731A0 (es) 1987-05-01
EP0159823B1 (en) 1989-08-09
JPS60218392A (ja) 1985-11-01
ES8705447A1 (es) 1987-05-01
DE3572172D1 (en) 1989-09-14
ES8607306A1 (es) 1986-05-16
FR2566777A1 (fr) 1986-01-03
IT8567298A1 (it) 1986-09-26
EP0159823A1 (en) 1985-10-30
ES541630A0 (es) 1986-05-16
IT1184058B (it) 1987-10-22

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Legal Events

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