JPS5630987A - Preparation of 7alpha-methoxycephalosporin - Google Patents
Preparation of 7alpha-methoxycephalosporinInfo
- Publication number
- JPS5630987A JPS5630987A JP10680779A JP10680779A JPS5630987A JP S5630987 A JPS5630987 A JP S5630987A JP 10680779 A JP10680779 A JP 10680779A JP 10680779 A JP10680779 A JP 10680779A JP S5630987 A JPS5630987 A JP S5630987A
- Authority
- JP
- Japan
- Prior art keywords
- carboxylic acid
- methanol
- alkali metal
- metal salt
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE: To obtain the titled compound directly and readily useful as a synthetic intermediate for antibiotics without removing a protecting group during preparation, by treating a cephalosporin compound with a halogenating agent in the presence of methanol and its alkali metal salt.
CONSTITUTION: A 7β-R1SO3CH2CONH-Δ3-cephem-4-carboxylic acid (R1 is hydrocarbon group )[e.g., a compound shown by the formula (A is an organic residue not taking part in the reaction; -COOW is carboxylic acid or its derivative), etc.] is reacted with an alkali metal salt of methanol in an inert solvent at -95W10°C. The resulting compound is treated with a halogenating agent (e.g., Cl, Br. or N- haloamide) capable of producing a positive halogen in the reaction solution at the same temperature as that of the solution. After the reaction, excess alkali metal salt of methanol is decomposed by a carboxylic acid, e.g., formic acid, etc. to give a 7α- methoxy-7β-R1SO3CH2CONH-Δ3-cephem-4-carboxylic acid.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10680779A JPS5630987A (en) | 1979-08-21 | 1979-08-21 | Preparation of 7alpha-methoxycephalosporin |
CA000358275A CA1152980A (en) | 1979-08-21 | 1980-08-14 | PROCESS FOR PRODUCING 7-.alpha.-METHOXYCEPHALOSPORINS |
IT49520/80A IT1146168B (en) | 1979-08-21 | 1980-08-19 | PROCEDURE FOR PRODUCING 7-METHOXY CEPHALOSPORINE |
HU802068A HU184815B (en) | 1979-08-21 | 1980-08-19 | Process for preparing 7alpha-methoxy-7beta-/cyano-methyl-acetamido-3-cefem-4-carboxylic acid derivatives |
ES494868A ES8106532A1 (en) | 1979-08-21 | 1980-08-20 | Preparation of 7alphaamethoxycephalosporin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10680779A JPS5630987A (en) | 1979-08-21 | 1979-08-21 | Preparation of 7alpha-methoxycephalosporin |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP18314786A Division JPS6242989A (en) | 1986-08-04 | 1986-08-04 | Production of 7alpha-methoxycephalosporin compound |
JP1703290A Division JPH02270882A (en) | 1990-01-26 | 1990-01-26 | Production of 7alpha-methoxycephalosporin compound |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5630987A true JPS5630987A (en) | 1981-03-28 |
JPH0231080B2 JPH0231080B2 (en) | 1990-07-11 |
Family
ID=14443116
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10680779A Granted JPS5630987A (en) | 1979-08-21 | 1979-08-21 | Preparation of 7alpha-methoxycephalosporin |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPS5630987A (en) |
CA (1) | CA1152980A (en) |
ES (1) | ES8106532A1 (en) |
HU (1) | HU184815B (en) |
IT (1) | IT1146168B (en) |
-
1979
- 1979-08-21 JP JP10680779A patent/JPS5630987A/en active Granted
-
1980
- 1980-08-14 CA CA000358275A patent/CA1152980A/en not_active Expired
- 1980-08-19 HU HU802068A patent/HU184815B/en unknown
- 1980-08-19 IT IT49520/80A patent/IT1146168B/en active
- 1980-08-20 ES ES494868A patent/ES8106532A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
HU184815B (en) | 1984-10-29 |
IT1146168B (en) | 1986-11-12 |
JPH0231080B2 (en) | 1990-07-11 |
IT8049520A0 (en) | 1980-08-19 |
ES494868A0 (en) | 1981-09-01 |
CA1152980A (en) | 1983-08-30 |
ES8106532A1 (en) | 1981-09-01 |
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