ES474149A1 - Un procedimiento para la produccion de un derivado de feni- letanolamina - Google Patents
Un procedimiento para la produccion de un derivado de feni- letanolaminaInfo
- Publication number
- ES474149A1 ES474149A1 ES474149A ES474149A ES474149A1 ES 474149 A1 ES474149 A1 ES 474149A1 ES 474149 A ES474149 A ES 474149A ES 474149 A ES474149 A ES 474149A ES 474149 A1 ES474149 A1 ES 474149A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- substituent
- arylthio
- aryloxy
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ULSIYEODSMZIPX-UHFFFAOYSA-N phenylethanolamine Chemical class NCC(O)C1=CC=CC=C1 ULSIYEODSMZIPX-UHFFFAOYSA-N 0.000 title abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000005110 aryl thio group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- BNBQRQQYDMDJAH-UHFFFAOYSA-N benzodioxan Chemical group C1=CC=C2OCCOC2=C1 BNBQRQQYDMDJAH-UHFFFAOYSA-N 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/64—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12203477A JPS5473751A (en) | 1977-10-12 | 1977-10-12 | Phenyl ethanolamine derivatives and their preparation |
| JP12843677A JPS5463048A (en) | 1977-10-26 | 1977-10-26 | Novel phenyl ethanolamine derivatives and their preparation |
| JP15535277A JPS5495544A (en) | 1977-12-23 | 1977-12-23 | Phenylethanolamine derivative and its preparation |
| JP7496478A JPS552639A (en) | 1978-06-21 | 1978-06-21 | Phenylethanolamine derivative and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES474149A1 true ES474149A1 (es) | 1979-10-16 |
Family
ID=27465764
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES474149A Expired ES474149A1 (es) | 1977-10-12 | 1978-10-11 | Un procedimiento para la produccion de un derivado de feni- letanolamina |
| ES481549A Expired ES481549A1 (es) | 1977-10-12 | 1979-06-13 | Un procedimiento para la producicion de un derivado de feni-letanolamina. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES481549A Expired ES481549A1 (es) | 1977-10-12 | 1979-06-13 | Un procedimiento para la producicion de un derivado de feni-letanolamina. |
Country Status (16)
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55124742A (en) * | 1979-03-20 | 1980-09-26 | Kyowa Hakko Kogyo Co Ltd | Novel aminoalcohol derivative |
| US4206125A (en) * | 1979-05-04 | 1980-06-03 | Richardson-Merrell Inc. | 5-[2-[(2,3-Dihydro-1,4-benzodioxan-2-ylmethyl)amino]-1-hydroxyethyl]-2-hydroxybenzoic acid derivatives |
| DD157796A5 (de) * | 1979-12-04 | 1982-12-08 | Ciba Geigy Ag | Verfahren zur herstellung neuer derivate des 2-amino-aethanols |
| JPS56110665A (en) * | 1980-02-08 | 1981-09-01 | Yamanouchi Pharmaceut Co Ltd | Sulfamoyl-substituted phenetylamine derivative and its preparation |
| US4558156A (en) * | 1980-02-08 | 1985-12-10 | Yamanouchi Pharmaceutical Co., Ltd. | Sulfamoyl-substituted phenethylamine derivatives |
| US5391825A (en) * | 1980-02-08 | 1995-02-21 | Yamanouchi Pharmaceutical Co., Ltd. | Sulfamoyl substituted phenethylamine intermediates |
| DE3128117A1 (de) * | 1980-07-29 | 1982-03-11 | Yamanouchi Pharmaceutical Co., Ltd., Tokyo | Neue phenyl-aethylaminderivate, verfahren zu ihrer herstellung |
| CA1219865A (en) * | 1982-05-14 | 1987-03-31 | Leo Alig | Aziridine phenethanolamine derivatives |
| PT78388B (en) * | 1983-04-12 | 1986-09-15 | Smithkline Beckman Corp | Dopamine-beta-hydroxylase inhibitors |
| JPS6051106A (ja) * | 1983-08-31 | 1985-03-22 | Yamanouchi Pharmaceut Co Ltd | 塩酸アモスラロ−ル持続性製剤 |
| EP0162404B1 (en) * | 1984-05-15 | 1988-08-24 | Seitetsu Kagaku Co., Ltd. | Process for preparing 2-alkyl-5-haloacetylbenzenesulfonamide |
| US4678855A (en) * | 1985-10-09 | 1987-07-07 | Merck & Co., Inc. | Substituted benzenesulfonamides |
| JPS62114952A (ja) * | 1985-11-13 | 1987-05-26 | Yamanouchi Pharmaceut Co Ltd | 置換フエネチルアミン誘導体の製造法 |
| JPH0228141A (ja) * | 1987-11-13 | 1990-01-30 | Glaxo Group Ltd | フェネタノールアミン誘導体 |
| EP0642789B1 (en) * | 1992-05-22 | 1999-09-29 | Senju Pharmaceutical Co., Ltd. | Remedy for glaucoma |
| FR2737494B1 (fr) * | 1995-08-04 | 1997-08-29 | Synthelabo | Derives de benzenesulfonamide, leur preparation et leur application en therapeutique |
| CA2242351C (en) * | 1996-01-10 | 2003-03-11 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel tricyclic compounds and drug compositions containing the same |
| WO1999057131A1 (en) * | 1998-05-06 | 1999-11-11 | Duke University | Method of treating bladder and lower urinary tract syndromes |
| FR2791675B1 (fr) * | 1999-03-30 | 2001-05-04 | Synthelabo | Derives de n-[2-(4-aminophenyl) ethyl] -2,3-dihydro-1,4- benzodioxinne-2-methanamine, leur preparation et leur application en therapeutique |
| US6835853B2 (en) * | 2001-10-31 | 2004-12-28 | Synthon Bv | Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith |
| HRP20050163A2 (en) | 2002-08-19 | 2005-06-30 | Pfizer Products Inc. | Combination therapy for hyperproliferative diseases |
| AU2004242777B2 (en) | 2003-05-30 | 2011-05-12 | Ranbaxy Laboratories Limited | Substituted pyrrole derivatives and their use as HMG-Co inhibitors |
| KR100596373B1 (ko) | 2003-12-09 | 2006-07-04 | 씨제이 주식회사 | 광학적으로 순수한 펜에틸 아민 유도체의 제조방법 |
| AP2007003979A0 (en) * | 2004-11-23 | 2007-06-30 | Warner Lambert Co | 7-(2h-pyrazol-3-yl)-3,5-dihyroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for thetreatment of lipidemia |
| CN100569745C (zh) * | 2005-05-27 | 2009-12-16 | 国际威林生化科技股份有限公司 | 制备坦舒乐欣的方法 |
| GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| BRPI0618379A2 (pt) | 2005-11-08 | 2011-08-30 | Ranbaxy Lab Ltd | processo para preparação do hemi-sal de cálcio do ácido (3r,5r) -7-[2-(4-fluorofenil)-5-isopropil-3-fenil-4-[(4-hidroxime tilfenilamino) carbonil]-pirrol-1-il] -3, 5-diidroxi heptanóico |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| EP2026766A1 (en) | 2006-05-17 | 2009-02-25 | Synthon B.V. | Tablet composition with a prolonged release of tamsulosin |
| US8404896B2 (en) | 2006-12-01 | 2013-03-26 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
| US8465770B2 (en) * | 2008-12-24 | 2013-06-18 | Synthon Bv | Low dose controlled release tablet |
| CN102050766B (zh) * | 2009-11-03 | 2013-08-07 | 安徽省新星药物开发有限责任公司 | 一种盐酸氨磺洛尔的合成方法 |
| HK1213886A1 (zh) | 2013-04-17 | 2016-07-15 | 辉瑞大药厂 | 用於治療心血管疾病的n-哌啶-3-基苯甲酰胺衍生物 |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| MX2021008533A (es) | 2019-01-18 | 2021-08-19 | Astrazeneca Ab | Inhibidores de la pcsk9 y metodos de uso de los mismos. |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3701808A (en) * | 1967-12-21 | 1972-10-31 | Allen & Hanburys Ltd | Phenylethanolamines |
| GB1266058A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1969-07-08 | 1972-03-08 | ||
| GB1321701A (en) | 1969-10-01 | 1973-06-27 | Continental Pharma | Amino-alcohols their salts and process for prepairing the same |
| US3711545A (en) * | 1971-02-23 | 1973-01-16 | Smith Kline French Lab | Alpha-aminoalkyl-4-hydroxy-3-sulfamoylaminobenzyl alcohols |
| DE2115926C3 (de) * | 1971-04-01 | 1978-05-03 | C.H. Boehringer Sohn, 6507 Ingelheim | 1 -(4-Hydroxy-3-dimethylaminosuIfamidophenyI)-2-aminoäthanderivate, Verfahren zu ihrer Herstellung und diese enthaltende Mittel |
| US4034112A (en) * | 1973-06-22 | 1977-07-05 | Imperial Chemical Industries Limited | Ethanolamine derivatives having β-adrenergic blocking activity |
| US3860647A (en) * | 1973-08-20 | 1975-01-14 | Smithkline Corp | {60 -Aminomethyl-4-hydroxy-3-sulfamyl-benzyl alcohols and 4-hydroxy-3-sulfamyl phenethylamines |
| GB1593651A (en) * | 1977-02-03 | 1981-07-22 | Allen & Hanburys Ltd | Amides |
| DK31578A (da) * | 1977-02-03 | 1978-08-04 | Allen & Hanburys Ltd | Fremgangsmaade til fremstilling af benzenderivater |
-
1978
- 1978-09-22 CA CA000311934A patent/CA1147342A/en not_active Expired
- 1978-09-25 GR GR57301A patent/GR65337B/el unknown
- 1978-09-27 US US05/946,192 patent/US4217305A/en not_active Expired - Lifetime
- 1978-10-02 CH CH1021878A patent/CH639948A5/de not_active IP Right Cessation
- 1978-10-03 DE DE19782843016 patent/DE2843016A1/de active Granted
- 1978-10-06 PT PT68624A patent/PT68624A/pt unknown
- 1978-10-09 FR FR7828743A patent/FR2405931A1/fr active Granted
- 1978-10-11 AT AT0731778A patent/AT363457B/de not_active IP Right Cessation
- 1978-10-11 DK DK452178A patent/DK168484B1/da active
- 1978-10-11 IT IT69350/78A patent/IT1160853B/it active
- 1978-10-11 SE SE7810613A patent/SE448232B/sv not_active IP Right Cessation
- 1978-10-11 ES ES474149A patent/ES474149A1/es not_active Expired
- 1978-10-11 NO NO783442A patent/NO147148C/no unknown
- 1978-10-11 SU SU782673556A patent/SU982537A3/ru active
- 1978-10-12 AU AU40642/78A patent/AU526715B2/en not_active Expired
- 1978-10-12 GB GB7840390A patent/GB2006772B/en not_active Expired
-
1979
- 1979-06-13 ES ES481549A patent/ES481549A1/es not_active Expired
- 1979-10-18 SU SU792835396A patent/SU932982A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| AU4064278A (en) | 1980-04-17 |
| ATA731778A (de) | 1981-01-15 |
| FR2405931A1 (fr) | 1979-05-11 |
| SE448232B (sv) | 1987-02-02 |
| GB2006772B (en) | 1982-02-03 |
| IT1160853B (it) | 1987-03-11 |
| CH639948A5 (de) | 1983-12-15 |
| GR65337B (en) | 1980-08-18 |
| DK452178A (da) | 1979-04-13 |
| NO783442L (no) | 1979-04-18 |
| PT68624A (en) | 1978-11-01 |
| IT7869350A0 (it) | 1978-10-11 |
| ES481549A1 (es) | 1980-04-01 |
| DE2843016C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1988-10-13 |
| SU982537A3 (ru) | 1982-12-15 |
| NO147148C (no) | 1983-02-09 |
| SU932982A3 (ru) | 1982-05-30 |
| AU526715B2 (en) | 1983-01-27 |
| DK168484B1 (da) | 1994-04-05 |
| NO147148B (no) | 1982-11-01 |
| US4217305A (en) | 1980-08-12 |
| SE7810613L (sv) | 1979-04-13 |
| GB2006772A (en) | 1979-05-10 |
| DE2843016A1 (de) | 1979-04-26 |
| CA1147342A (en) | 1983-05-31 |
| FR2405931B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1982-11-19 |
| AT363457B (de) | 1981-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20001204 |