ES464141A1 - Un procedimiento para la conversion enzimatica de una peni- cilina a un acido 6-aminopenicilanico. - Google Patents

Un procedimiento para la conversion enzimatica de una peni- cilina a un acido 6-aminopenicilanico.

Info

Publication number
ES464141A1
ES464141A1 ES464141A ES464141A ES464141A1 ES 464141 A1 ES464141 A1 ES 464141A1 ES 464141 A ES464141 A ES 464141A ES 464141 A ES464141 A ES 464141A ES 464141 A1 ES464141 A1 ES 464141A1
Authority
ES
Spain
Prior art keywords
preparing
aminopenicillanic acid
aminopenicillanic
acid
bed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES464141A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES464141A1 publication Critical patent/ES464141A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/42—Compounds with a free primary amino radical attached in position 6
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/873—Proteus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procedimiento para la conversión enzimática de una penicilina a un ácido 6-aminopenicilánico, caracterizado porque se pone en contacto una solución acuosa de dicha penicilina con un catalizador de acilasa de penicilina inmovilizado, en partículas, caracterizado porque dicha solución se hace recircular a través de un lecho que está constituido de dicho catalizador en partículas, a un régimen de flujo de cuando menos 0,4 del volumen de lecho por minuto, mientras se mantiene dicha solución a una temperatura de aproximadamente 15 a 45ºC y a un pH de aproximadamente 6,5 a 9,0, y dicha recirculación se continúa hasta que dicha penicilina está substancialmente convertida al ácido mencionado teniendo el citado lecho una profundidad de hasta aproximadamente 6 centímetros.
ES464141A 1976-11-26 1977-11-15 Un procedimiento para la conversion enzimatica de una peni- cilina a un acido 6-aminopenicilanico. Expired ES464141A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/745,212 US4113566A (en) 1976-11-26 1976-11-26 Process for preparing 6-aminopenicillanic acid

Publications (1)

Publication Number Publication Date
ES464141A1 true ES464141A1 (es) 1978-09-01

Family

ID=24995717

Family Applications (1)

Application Number Title Priority Date Filing Date
ES464141A Expired ES464141A1 (es) 1976-11-26 1977-11-15 Un procedimiento para la conversion enzimatica de una peni- cilina a un acido 6-aminopenicilanico.

Country Status (29)

Country Link
US (1) US4113566A (es)
JP (1) JPS5369888A (es)
AR (1) AR218273A1 (es)
AU (1) AU500707B1 (es)
BE (1) BE861207A (es)
BG (1) BG32859A3 (es)
CA (1) CA1089383A (es)
CH (1) CH625556A5 (es)
CS (1) CS207715B2 (es)
DD (1) DD133674A5 (es)
DE (1) DE2752499C2 (es)
DK (1) DK144277C (es)
ES (1) ES464141A1 (es)
FR (1) FR2372166A1 (es)
GB (1) GB1537640A (es)
HU (1) HU176598B (es)
IE (1) IE45997B1 (es)
IN (1) IN147632B (es)
IT (1) IT1092206B (es)
LU (1) LU78585A1 (es)
MX (1) MX4233E (es)
NL (1) NL171821C (es)
PH (1) PH12580A (es)
PL (1) PL109707B1 (es)
RO (1) RO73018A (es)
SE (1) SE434157B (es)
SU (1) SU719504A3 (es)
YU (1) YU267977A (es)
ZA (1) ZA777018B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2429912R1 (es) * 2012-05-14 2014-02-19 Universidad Autónoma de Madrid Polipéptido termoestable con actividad penicilina acilasa, variantes del mismo y sus aplicaciones

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59110763U (ja) * 1983-01-18 1984-07-26 日産自動車株式会社 パ−キングブレ−キ力伝達装置
DK0567323T3 (da) * 1992-04-24 1999-12-13 Lilly Co Eli Forbedret fremgangsmåde til fremstilling af cephalosporiner
US6107067A (en) * 1998-07-06 2000-08-22 W.R. Grace & Co.-Conn. Porous, non-macroporous, inorganic oxide carrier body for immobilizing microorganisms for bioremediation
NZ743040A (en) 2009-05-20 2020-01-31 Xyleco Inc Bioprocessing
CN105254520B (zh) * 2015-10-12 2017-07-07 国药集团威奇达药业有限公司 酶法合成阿莫西林结晶母液中d‑对羟基苯甘氨酸的回收方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3239427A (en) * 1959-10-12 1966-03-08 Pfizer & Co C Production of 6-aminopenicillanic acid
US3694314A (en) * 1970-11-09 1972-09-26 Standard Brands Inc Process for isomerizing glucose to fructose
US3817832A (en) * 1970-11-09 1974-06-18 Standard Brands Inc Process for isomerizing glucose to fructose
IL39158A (en) 1971-04-28 1977-08-31 Snam Progetti Enzymatic scission and synthesis of penicillins and cephalosporins
BE791748A (fr) * 1971-11-23 1973-05-22 Bayer Ag Procede de production d'acide 6-aminopenicillanique par ruptureenzymatique de penicillines
DE2215539C2 (de) * 1972-03-30 1984-08-02 Bayer Ag, 5090 Leverkusen Neue wasserunlösliche Enzym-, insbesondere Penicillinacylase-oder Enzyminhibitor-Präparate
GB1400468A (en) * 1972-07-22 1975-07-16 Beecham Group Ltd Enzyme preparation and use thereof
JPS5317674B2 (es) * 1973-05-30 1978-06-09
CH597237A5 (es) * 1974-01-31 1978-03-31 Biochemie Gmbh
US3905868A (en) * 1974-12-04 1975-09-16 Pfizer Enzymatic deacylation of benzyl- and phenoxymethylpenicillin tetrazoles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2429912R1 (es) * 2012-05-14 2014-02-19 Universidad Autónoma de Madrid Polipéptido termoestable con actividad penicilina acilasa, variantes del mismo y sus aplicaciones

Also Published As

Publication number Publication date
NL7712999A (nl) 1978-05-30
DD133674A5 (de) 1979-01-17
NL171821B (nl) 1982-12-16
DK144277B (da) 1982-02-01
PL109707B1 (en) 1980-06-30
SE7712006L (sv) 1978-05-27
BG32859A3 (en) 1982-10-15
DK144277C (da) 1982-07-05
DE2752499A1 (de) 1978-06-01
NL171821C (nl) 1983-05-16
RO73018A (ro) 1981-11-04
AR218273A1 (es) 1980-05-30
FR2372166A1 (fr) 1978-06-23
DK524977A (da) 1978-05-27
CA1089383A (en) 1980-11-11
ZA777018B (en) 1978-09-27
CS207715B2 (en) 1981-08-31
IE45997B1 (en) 1983-01-26
IN147632B (es) 1980-05-03
IT1092206B (it) 1985-07-06
DE2752499C2 (de) 1986-05-07
BE861207A (fr) 1978-05-25
JPS5369888A (en) 1978-06-21
CH625556A5 (es) 1981-09-30
PL202402A1 (pl) 1978-08-28
HU176598B (en) 1981-03-28
YU267977A (en) 1982-06-30
LU78585A1 (fr) 1979-06-13
SE434157B (sv) 1984-07-09
PH12580A (en) 1979-06-20
SU719504A3 (ru) 1980-02-29
JPS5650839B2 (es) 1981-12-01
AU500707B1 (en) 1979-05-31
IE45997L (en) 1978-05-26
FR2372166B1 (es) 1982-12-17
MX4233E (es) 1982-02-19
US4113566A (en) 1978-09-12
GB1537640A (en) 1979-01-04

Similar Documents

Publication Publication Date Title
HU173670B (hu) Sposob poluchenija 20-alkoksi-21-fenilsul'fonil-pregna-4,17-skobka-20-skobka zakryta-dien-3-onov
HRP931394B1 (en) Process for the transformation of esters, cis or trans-2,2-dimethyl-3r(2,2-dihalogeno vinyl)-cyclopropane-1r of carbixilic acid
YU40470B (en) Process for obtaining mixed aromatic, aliphatic phosphates
ES465742A1 (es) Un procedimiento para la preparacion de nuevas pirazincar- boxamidas.
HU173003B (hu) Sposob poluchenija novykh tiazolo-skobka-3,4-b-skobka zakryta-izokinolinov
ES464141A1 (es) Un procedimiento para la conversion enzimatica de una peni- cilina a un acido 6-aminopenicilanico.
PT66808A (en) Process for preparing 5-m-tolyloxyuracil,useful as an anti-ulcer agent
HU174389B (hu) Sposob poluchenija 1-poligalogenalkil-3,4-digidro-2-skobka-1h-skobka zakryta-kinazolinonov i -tionov
EG12328A (en) Process for preparing of substituted 2-phenylimino-1,3-dithiolanes
YU40433B (en) Process for obtaining pure, proteolytically active anzymes
HU178507B (en) Process for producing n,n-comma above-bis-trimethyl-silil-urea
ES8202545A1 (es) Metodo perfeccionado para la fabricacion de 4-tiazolidonas,2-substituidas
HU173129B (hu) Sposob poluchenija novykh proizvodnykh zamehhennykh penam- i cefem-soedinenijj soderzhahhikh piperazino-gruppy
PH15677A (en) Process for the production of 2,9-dioxatricyclo(4,3,1,0 3)decanes
YU40265B (en) Process for obtaining arysulfonylcarbomoyl-1,3-dicarbonyl compounds
YU39659B (en) Process for producing 1,-n-(alpha-hydroxy-omega-aminoacyl)-6'-n-methyl-3',4'-dideoxykanamycin b
GB1550722A (en) Process for the production of 2,3-cycloalkenopyridines
YU195476A (en) Process for obtaining n,n-diethyla-2-(delta-naphthoxy)-propionamide
FR2407916B1 (es)
CA1033739A (en) Process for preparing cyanoquinoaxaline 1,4-dioxides
CS191211B2 (en) Method of production of the 0,0-dimethyl-event. 0,0-diethyl-0-/2,2-dichlorvinyl/esters of the thionofosfor for acid
HU173644B (hu) Sposob poluchenija cis-n,n-dimetil-9-skobka-3-skobka-4-metil-1-piperazinil-skobka zakryta-propileden-skobka zakryta-tioksanten-2-sul'fonamida
CA1032164A (en) Process for preparing acylaminoquinoxaline-carboxamide 1,4-dioxides
JPS5257156A (en) Process for preparing 5,6_trans-24-hydroxycholecalciferol
JPS5281100A (en) Process for preparing ammoniumsulfate

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19940721