FR2036383A5 - Prepn of 6-aminopenicillanic acid by splitting penicillins - Google Patents

Prepn of 6-aminopenicillanic acid by splitting penicillins

Info

Publication number
FR2036383A5
FR2036383A5 FR6907013A FR6907013A FR2036383A5 FR 2036383 A5 FR2036383 A5 FR 2036383A5 FR 6907013 A FR6907013 A FR 6907013A FR 6907013 A FR6907013 A FR 6907013A FR 2036383 A5 FR2036383 A5 FR 2036383A5
Authority
FR
France
Prior art keywords
penicillins
prepn
splitting
aminopenicillanic acid
enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR6907013A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Priority to FR6907013A priority Critical patent/FR2036383A5/en
Application granted granted Critical
Publication of FR2036383A5 publication Critical patent/FR2036383A5/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/06—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Prepn. of 6-aminopenicillanic acid (I) by splitting penicillins with amidase enzymes and (1) using the enzyme separately from the broth in which it is produced; (2) adsorbing the enzyme on a bentonite for content with the penicillin; and (3) effecting the reaction in a medium maintained at pH 7-9 with NH3 or a cyclic amine. Increased yields of (I) and increased amounts of penicillin can be split for a given amount of enzyme; (I) used to prepare penicillins.
FR6907013A 1969-03-12 1969-03-12 Prepn of 6-aminopenicillanic acid by splitting penicillins Expired FR2036383A5 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR6907013A FR2036383A5 (en) 1969-03-12 1969-03-12 Prepn of 6-aminopenicillanic acid by splitting penicillins

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6907013A FR2036383A5 (en) 1969-03-12 1969-03-12 Prepn of 6-aminopenicillanic acid by splitting penicillins

Publications (1)

Publication Number Publication Date
FR2036383A5 true FR2036383A5 (en) 1970-12-24

Family

ID=9030534

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6907013A Expired FR2036383A5 (en) 1969-03-12 1969-03-12 Prepn of 6-aminopenicillanic acid by splitting penicillins

Country Status (1)

Country Link
FR (1) FR2036383A5 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122681A1 (en) * 1983-04-19 1984-10-24 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO Enzymatic process

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122681A1 (en) * 1983-04-19 1984-10-24 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO Enzymatic process

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Legal Events

Date Code Title Description
ST Notification of lapse