GB1391088A - Production of d-alpha-amino-1,4-cyclohexadienyl methyl penicillin - Google Patents

Production of d-alpha-amino-1,4-cyclohexadienyl methyl penicillin

Info

Publication number
GB1391088A
GB1391088A GB3701072A GB3701072A GB1391088A GB 1391088 A GB1391088 A GB 1391088A GB 3701072 A GB3701072 A GB 3701072A GB 3701072 A GB3701072 A GB 3701072A GB 1391088 A GB1391088 A GB 1391088A
Authority
GB
United Kingdom
Prior art keywords
cyclohexadienyl
amino
methyl
epicillin
aug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3701072A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of GB1391088A publication Critical patent/GB1391088A/en
Expired legal-status Critical Current

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

1391088 Preparing epicillin EISAI CO Ltd 8 Aug 1972 [12 Aug 1971] 37010/72 Heading C2C D - α - amino - (1,4 - cyclohexadienyl)methyl penicillin (epicillin) is prepared by reacting 6- aminopenicillanic acid or a salt thereof with an ester (preferably the methyl or ethyl ester) or amide of D-2-amino-2-(1,4-cyclohexadienyl)- acetic acid or an acid addition salt thereof in an aqueous medium in the presence of the microorganism Flavobacterium EF 44-102 Nov. Sp. (ATCC No. 21429), or an enzymatically active medium derived therefrom. The microorganism is aerobically grown on conventional medium and may be used as the culture broth, a cell extract, enzyme preparation, or the separated cells. D - 2 - Amino - 2 - (1,4 - cyclohexadienyl)- acetic acid is prepared by reducing D-phenylglycine with lithium in liquid ammonia. The compound is treeated with thionyl chloride in methanol to convert it to its methyl ester hydrochloride.
GB3701072A 1971-08-12 1972-08-08 Production of d-alpha-amino-1,4-cyclohexadienyl methyl penicillin Expired GB1391088A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6063671A JPS4826985A (en) 1971-08-12 1971-08-12

Publications (1)

Publication Number Publication Date
GB1391088A true GB1391088A (en) 1975-04-16

Family

ID=13147985

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3701072A Expired GB1391088A (en) 1971-08-12 1972-08-08 Production of d-alpha-amino-1,4-cyclohexadienyl methyl penicillin

Country Status (4)

Country Link
JP (1) JPS4826985A (en)
DE (1) DE2239608A1 (en)
FR (1) FR2148635B1 (en)
GB (1) GB1391088A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2240102A (en) * 1990-01-22 1991-07-24 Biochemie Gmbh Beta-lactam production

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW555855B (en) * 1996-07-26 2003-10-01 Bristol Myers Squibb Co Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2240102A (en) * 1990-01-22 1991-07-24 Biochemie Gmbh Beta-lactam production
GB2240102B (en) * 1990-01-22 1993-10-20 Biochemie Gmbh Improvements in or relating to beta lactam production

Also Published As

Publication number Publication date
FR2148635B1 (en) 1975-03-07
FR2148635A1 (en) 1973-03-23
DE2239608A1 (en) 1973-02-22
JPS4826985A (en) 1973-04-09

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee