IE41561L - Enzymatic deacylation of penicillin derivatives - Google Patents

Enzymatic deacylation of penicillin derivatives

Info

Publication number
IE41561L
IE41561L IE751356A IE135675A IE41561L IE 41561 L IE41561 L IE 41561L IE 751356 A IE751356 A IE 751356A IE 135675 A IE135675 A IE 135675A IE 41561 L IE41561 L IE 41561L
Authority
IE
Ireland
Prior art keywords
penicillin derivatives
enzymatic deacylation
deacylation
deacylate
penam
Prior art date
Application number
IE751356A
Other versions
IE41561B1 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IE41561L publication Critical patent/IE41561L/en
Publication of IE41561B1 publication Critical patent/IE41561B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/823—Acetobacter
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/83—Arthrobacter
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/839—Bacillus subtilis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
    • Y10S435/849—Escherichia coli
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/873—Proteus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Deacylation of benzyl- and phenoxymethylpenicillin tetrazoles to produce 6-amino-2,2-dimethyl-3-(tetrazol-5-yl)penam by the use of selected deacylases. The process is useful in the purification of said penam which is a valuable synthetic intermediate. It has been found that those enzymes which will deacylate benzyl- and phenoxymethylpenicillin will generally deacylate the corresponding tetrazoles. [US3905868A]
IE1356/75A 1974-12-04 1975-06-17 Enzymatic deacylation of benzyl- and phenoxymethylpenicillin tetrazoles IE41561B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US529480A US3905868A (en) 1974-12-04 1974-12-04 Enzymatic deacylation of benzyl- and phenoxymethylpenicillin tetrazoles

Publications (2)

Publication Number Publication Date
IE41561L true IE41561L (en) 1976-06-04
IE41561B1 IE41561B1 (en) 1980-01-30

Family

ID=24110086

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1356/75A IE41561B1 (en) 1974-12-04 1975-06-17 Enzymatic deacylation of benzyl- and phenoxymethylpenicillin tetrazoles

Country Status (10)

Country Link
US (1) US3905868A (en)
JP (1) JPS5198297A (en)
BE (1) BE832144A (en)
DE (1) DE2533820A1 (en)
DK (1) DK358575A (en)
FR (1) FR2309557A1 (en)
GB (1) GB1481760A (en)
IE (1) IE41561B1 (en)
LU (1) LU73181A1 (en)
NL (1) NL7508961A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4113566A (en) * 1976-11-26 1978-09-12 Pfizer Inc. Process for preparing 6-aminopenicillanic acid
US5212078A (en) * 1989-08-28 1993-05-18 International Flavors And Fragrances Inc. Process for producing a lactone
US5155029A (en) * 1989-08-28 1992-10-13 International Flavors & Fragrances Inc. Process for producing a cyclic ether
US4970163A (en) * 1989-08-28 1990-11-13 International Flavors & Fragrances Inc. Process for producing diol and lactone and microorganisms capable of same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3736230A (en) * 1969-02-17 1973-05-29 P Delin Process for producing 6-amino-penicillanic acid

Also Published As

Publication number Publication date
FR2309557A1 (en) 1976-11-26
BE832144A (en) 1976-02-06
GB1481760A (en) 1977-08-03
DK358575A (en) 1976-06-05
JPS5198297A (en) 1976-08-30
DE2533820A1 (en) 1976-06-16
US3905868A (en) 1975-09-16
FR2309557B1 (en) 1977-12-16
NL7508961A (en) 1976-06-09
IE41561B1 (en) 1980-01-30
LU73181A1 (en) 1976-08-13

Similar Documents

Publication Publication Date Title
IE36881L (en) 7, 7-disubstituted cepalosporins and 6, 6-disubstituted¹penicillins
GR80987B (en) Process for the preparation of oligosaccharides-containing products from biomass, oligosaccharides-containing products and their use
ES426272A1 (en) Preparation of cephalosporin compounds
CA1012981A (en) Method for the recovery of unreacted compound in the production of urea
IE41561L (en) Enzymatic deacylation of penicillin derivatives
GB1518759A (en) Method of making steering wheels
ATE133204T1 (en) METHOD FOR THE CONTINUOUS CONVERSION OF CEPHALOSPORINE DERIVATIVES TO GLUTARYL-7-AMINO-CEPHALOSPORAN ACID DERIVATIVES
IE38150B1 (en) Process for preparing desacetoxycephalosporins and novel intermediates
ES420695A1 (en) 6-Aminopenicillanic acid preparation
IE42209L (en) 1-alkyl-2-(phenoxymethyl)-5-nitro-imidazoles
JPS51133488A (en) Process for producing antibiotics enzymatically
IE36761L (en) Penicillin acylase
IE42380L (en) Deacetoxy cephalosporins via penicillin sulfoxide¹rearrangement.
ES468942A1 (en) Method for producing cepham compounds
ES385907A1 (en) Process for the production of 6-aminopenicillanic acid
GB1479174A (en) Process for the preparation of 6-amino-penicillanic acid 1-oxide
GB1516899A (en) Process for the manufacture of hexamethyldisilazane
GB961517A (en) Process of producing 6-aminopenicillanic acid
JPS5394093A (en) Novel process for preparation of 7-amino-cephalosporanic acid and their derivatives
FR2036383A5 (en) Prepn of 6-aminopenicillanic acid by splitting penicillins
IE890128L (en) Method of producing 2-substituted oximino-3-oxobutyric¹acids.
ES435618A1 (en) Process of making cephamycin C by fermentation
GB924455A (en) Production of 6-aminopenicillanic acid
ES427389A1 (en) Process for cleaving an imido side chain from penicillins and cephalosporins
AU8624975A (en) A process for the conversion of 6-aminopenicillanic acid (6-apa) into 7-aminodesacetoxycephalosporanic acid (7-adca)