NL7215682A - 6-amino-penicillanic acid prepn - by enzymatic splitting of penicillins - Google Patents

6-amino-penicillanic acid prepn - by enzymatic splitting of penicillins

Info

Publication number
NL7215682A
NL7215682A NL7215682A NL7215682A NL7215682A NL 7215682 A NL7215682 A NL 7215682A NL 7215682 A NL7215682 A NL 7215682A NL 7215682 A NL7215682 A NL 7215682A NL 7215682 A NL7215682 A NL 7215682A
Authority
NL
Netherlands
Prior art keywords
penicillins
amino
penicillanic acid
enzymatic splitting
acid prepn
Prior art date
Application number
NL7215682A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2157972A external-priority patent/DE2157972C3/en
Priority claimed from DE2157970A external-priority patent/DE2157970C3/en
Application filed filed Critical
Publication of NL7215682A publication Critical patent/NL7215682A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/06—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/087—Acrylic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

6-APA is prepd. by stirring penicillin soln. of pH 6-8, pref. 7-7.8, at 20-50 degrees C, pref. 38 degrees C, with suspension of penicillin acylase which is covalently bound to a copolymer of acrylamide, N,N1-methylene bisacrylamide and maleic acid anhydride, for 3-20 hrs. The mixt. neutralised and the 6-APA isolated in known manner.
NL7215682A 1971-11-23 1972-11-20 6-amino-penicillanic acid prepn - by enzymatic splitting of penicillins NL7215682A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2157972A DE2157972C3 (en) 1971-11-23 1971-11-23 Carrier-bound penicillin acylase
DE2157970A DE2157970C3 (en) 1971-11-23 1971-11-23 Process for the production of 6-aminopenicillanic acid by cleavage of penicillin G by means of carrier-bound penicillin acylase

Publications (1)

Publication Number Publication Date
NL7215682A true NL7215682A (en) 1973-05-25

Family

ID=25762064

Family Applications (2)

Application Number Title Priority Date Filing Date
NL7215683A NL7215683A (en) 1971-11-23 1972-11-20
NL7215682A NL7215682A (en) 1971-11-23 1972-11-20 6-amino-penicillanic acid prepn - by enzymatic splitting of penicillins

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NL7215683A NL7215683A (en) 1971-11-23 1972-11-20

Country Status (1)

Country Link
NL (2) NL7215683A (en)

Also Published As

Publication number Publication date
NL7215683A (en) 1973-05-25

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Legal Events

Date Code Title Description
BB A search report has been drawn up
BC A request for examination has been filed
BV The patent application has lapsed