BE807564A - 6-Aminopenicillanic acid prodn - from penicillins with a soluble penici-llin-deacylase/absorbent prepn - Google Patents

6-Aminopenicillanic acid prodn - from penicillins with a soluble penici-llin-deacylase/absorbent prepn

Info

Publication number
BE807564A
BE807564A BE137963A BE137963A BE807564A BE 807564 A BE807564 A BE 807564A BE 137963 A BE137963 A BE 137963A BE 137963 A BE137963 A BE 137963A BE 807564 A BE807564 A BE 807564A
Authority
BE
Belgium
Prior art keywords
soluble
absorbent
prepn
water
aminopenicillanic acid
Prior art date
Application number
BE137963A
Other languages
French (fr)
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB5382272A external-priority patent/GB1449808A/en
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of BE807564A publication Critical patent/BE807564A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/42—Compounds with a free primary amino radical attached in position 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

6-Aminopenicillanic acid (6-APA) is produced by (a) treating an aqs. soln. of benzylpenicillin (Ia) or phenoxymethylpenicillin (Ib) or a salt thereof at a pH of 6.0-9.0 with a water-soluble enzyme prepn. comprising a penicillin desacylase and a solid, water-soluble absorbent, (b) separating the enzyme prepn. from the reaction mixt. by ultrafiltration, (c) isolating the resulting 6-APA; and (d) reacting the enzyme prepn. with more (Ia) or (Ib). The absorbent is pref. (i) a maleic anhydride polymer, esp. a copolymer with methyl vinyl ether, or (ii) a modified polysaccharide polymer esp. a sucrose/epichlorohydrin copolymer. The water-soluble enzyme prepns. allow more concd. solns. to be used than do water-insoluble prepns, and the reaction mixt. is homogeneous, thus facilitating continuous operation.
BE137963A 1972-11-21 1973-11-20 6-Aminopenicillanic acid prodn - from penicillins with a soluble penici-llin-deacylase/absorbent prepn BE807564A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5382272A GB1449808A (en) 1972-11-21 1972-11-21 6-aminopenicillanic acid preparation

Publications (1)

Publication Number Publication Date
BE807564A true BE807564A (en) 1974-05-20

Family

ID=10469094

Family Applications (1)

Application Number Title Priority Date Filing Date
BE137963A BE807564A (en) 1972-11-21 1973-11-20 6-Aminopenicillanic acid prodn - from penicillins with a soluble penici-llin-deacylase/absorbent prepn

Country Status (4)

Country Link
BE (1) BE807564A (en)
BR (1) BR7309101D0 (en)
SU (1) SU578834A3 (en)
ZA (1) ZA738457B (en)

Also Published As

Publication number Publication date
SU578834A3 (en) 1977-10-30
BR7309101D0 (en) 1974-08-29
ZA738457B (en) 1974-09-25

Similar Documents

Publication Publication Date Title
IE37861L (en) Enzyme preparation
ES420695A1 (en) 6-Aminopenicillanic acid preparation
BE807564A (en) 6-Aminopenicillanic acid prodn - from penicillins with a soluble penici-llin-deacylase/absorbent prepn
CA1000687A (en) Method of chemically coupling biologically active substances to oxirane-containing polymers
SE7415863L (en)
FR2073007A5 (en) Immobielised active enzyme products
IE35402B1 (en) Process for producing 6-aminopenicillanic acid
SE431768B (en) PROCEDURE FOR THE PREPARATION OF 6-AMINOPENICILLANIC ACID BY THE PROCESSING OF PENICILLIN AND INTRODUCED INTRODUCED PENICILLINAMIDAS PRODUCING MICROORGANISM, INCLUDED IN AN ACRYLIC AMPOLYMER
IE36851B1 (en) The production of 6-aminopenicillanic acid
IE41292B1 (en) Improvments in or relating to penicillins
CA978495A (en) Process for isolating formaldehyde from mixtures of acetic acid, formaldehyde and water
NL7215682A (en) 6-amino-penicillanic acid prepn - by enzymatic splitting of penicillins
FR2051289A5 (en) Maleic anhydride-vinyl acetate copolymers
FR2188608A5 (en) Penicillins prepn by acylating 6-apa - in presence of catalytic enzymes using free acids
FR2036383A5 (en) Prepn of 6-aminopenicillanic acid by splitting penicillins
FR2005645A1 (en) Water insoluble enzyme prepn and improved method for 6-amino-penicilla - nic acid
GB1349498A (en) Water-insoluble bound enzyme
IE36850L (en) Penicillin acylase
IE39964B1 (en) 6-(amidino-and imidoylaminoalkanoylamino) aracylamino) penicillanic acids and their preparation
KR790000400B1 (en) Process for preparation 6-aminopenicillanic acid
JPS56151497A (en) Production of penicillin and cephalosporin derivative
GB1357317A (en) Enzymes
IE35015B1 (en) An improved process for the production of zearalenone
GB1264147A (en)
ES364195A1 (en) Pronase purification

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: BEECHAM GROUP LTD

Effective date: 19841120