BE807564A - 6-Aminopenicillanic acid prodn - from penicillins with a soluble penici-llin-deacylase/absorbent prepn - Google Patents

6-Aminopenicillanic acid prodn - from penicillins with a soluble penici-llin-deacylase/absorbent prepn

Info

Publication number
BE807564A
BE807564A BE137963A BE137963A BE807564A BE 807564 A BE807564 A BE 807564A BE 137963 A BE137963 A BE 137963A BE 137963 A BE137963 A BE 137963A BE 807564 A BE807564 A BE 807564A
Authority
BE
Belgium
Prior art keywords
soluble
absorbent
prepn
water
aminopenicillanic acid
Prior art date
Application number
BE137963A
Other languages
French (fr)
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB5382272A external-priority patent/GB1449808A/en
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of BE807564A publication Critical patent/BE807564A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/42—Compounds with a free primary amino radical attached in position 6

Abstract

6-Aminopenicillanic acid (6-APA) is produced by (a) treating an aqs. soln. of benzylpenicillin (Ia) or phenoxymethylpenicillin (Ib) or a salt thereof at a pH of 6.0-9.0 with a water-soluble enzyme prepn. comprising a penicillin desacylase and a solid, water-soluble absorbent, (b) separating the enzyme prepn. from the reaction mixt. by ultrafiltration, (c) isolating the resulting 6-APA; and (d) reacting the enzyme prepn. with more (Ia) or (Ib). The absorbent is pref. (i) a maleic anhydride polymer, esp. a copolymer with methyl vinyl ether, or (ii) a modified polysaccharide polymer esp. a sucrose/epichlorohydrin copolymer. The water-soluble enzyme prepns. allow more concd. solns. to be used than do water-insoluble prepns, and the reaction mixt. is homogeneous, thus facilitating continuous operation.
BE137963A 1972-11-21 1973-11-20 6-Aminopenicillanic acid prodn - from penicillins with a soluble penici-llin-deacylase/absorbent prepn BE807564A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5382272A GB1449808A (en) 1972-11-21 1972-11-21 6-aminopenicillanic acid preparation

Publications (1)

Publication Number Publication Date
BE807564A true BE807564A (en) 1974-05-20

Family

ID=10469094

Family Applications (1)

Application Number Title Priority Date Filing Date
BE137963A BE807564A (en) 1972-11-21 1973-11-20 6-Aminopenicillanic acid prodn - from penicillins with a soluble penici-llin-deacylase/absorbent prepn

Country Status (4)

Country Link
BE (1) BE807564A (en)
BR (1) BR7309101D0 (en)
SU (1) SU578834A3 (en)
ZA (1) ZA738457B (en)

Also Published As

Publication number Publication date
SU578834A3 (en) 1977-10-30
ZA738457B (en) 1974-09-25
BR7309101D0 (en) 1974-08-29

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: BEECHAM GROUP LTD

Effective date: 19841120