FR2005645A1 - Water insoluble enzyme prepn and improved method for 6-amino-penicilla - nic acid - Google Patents

Water insoluble enzyme prepn and improved method for 6-amino-penicilla - nic acid

Info

Publication number
FR2005645A1
FR2005645A1 FR6910402A FR6910402A FR2005645A1 FR 2005645 A1 FR2005645 A1 FR 2005645A1 FR 6910402 A FR6910402 A FR 6910402A FR 6910402 A FR6910402 A FR 6910402A FR 2005645 A1 FR2005645 A1 FR 2005645A1
Authority
FR
France
Prior art keywords
improved method
water insoluble
penicilla
amino
insoluble enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR6910402A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of FR2005645A1 publication Critical patent/FR2005645A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C12N11/12—Cellulose or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/06—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

(A) A water insoluble enzyme prepn. (I) (B) Improved method for 6-aminopenicillanic acid. Deacylation of penicillin. A suitable acylase, obtd. e.g. from E. coli or fungal sources, is reacted with a suitable reactive carboxymethylcellulose, Zeocarb 226 acid chloride, or hydrazine cross-linked ethylene-maleic anhydride resins, tog. with the appropriate amide-forming reagent, e.g. DCCD. The coupled enzyme is esp. useful of for deacylation of benzyl and phenoxymethylpenicillins to 6-aminopenicillanic acid of high purity.
FR6910402A 1968-04-05 1969-04-04 Water insoluble enzyme prepn and improved method for 6-amino-penicilla - nic acid Withdrawn FR2005645A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB06446/68A GB1193918A (en) 1968-04-05 1968-04-05 Enzymes

Publications (1)

Publication Number Publication Date
FR2005645A1 true FR2005645A1 (en) 1969-12-12

Family

ID=10077470

Family Applications (1)

Application Number Title Priority Date Filing Date
FR6910402A Withdrawn FR2005645A1 (en) 1968-04-05 1969-04-04 Water insoluble enzyme prepn and improved method for 6-amino-penicilla - nic acid

Country Status (12)

Country Link
AT (1) AT286498B (en)
BE (1) BE730997A (en)
CH (1) CH549602A (en)
DE (1) DE1917057C2 (en)
ES (1) ES365631A1 (en)
FR (1) FR2005645A1 (en)
GB (1) GB1193918A (en)
IE (1) IE33023B1 (en)
IL (1) IL31925A (en)
NL (1) NL6904995A (en)
RO (1) RO57877A (en)
SE (1) SE359550B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2134530A1 (en) * 1971-04-28 1972-12-08 Snam Progetti
FR2222436A1 (en) * 1973-03-24 1974-10-18 Tanabe Seiyaku Co

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1492937A (en) * 1973-12-28 1977-11-23 Beecham Group Ltd Enzyme complexes and their use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3278392A (en) * 1962-11-12 1966-10-11 Yeda Res & Dev Water insoluble enzymes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2134530A1 (en) * 1971-04-28 1972-12-08 Snam Progetti
FR2222436A1 (en) * 1973-03-24 1974-10-18 Tanabe Seiyaku Co

Also Published As

Publication number Publication date
GB1193918A (en) 1970-06-03
SE359550B (en) 1973-09-03
RO57877A (en) 1975-04-15
IE33023L (en) 1969-10-05
ES365631A1 (en) 1971-03-16
AT286498B (en) 1970-12-10
IL31925A (en) 1973-03-30
IE33023B1 (en) 1974-02-20
DE1917057A1 (en) 1969-10-23
NL6904995A (en) 1969-10-07
BE730997A (en) 1969-10-03
DE1917057C2 (en) 1983-09-08
CH549602A (en) 1974-05-31
IL31925A0 (en) 1969-05-28

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Legal Events

Date Code Title Description
ST Notification of lapse