ES456134A1 - Procedimiento para la obtencion de esteres de acidos andros-tadien-17-carboxilicos. - Google Patents
Procedimiento para la obtencion de esteres de acidos andros-tadien-17-carboxilicos.Info
- Publication number
- ES456134A1 ES456134A1 ES456134A ES456134A ES456134A1 ES 456134 A1 ES456134 A1 ES 456134A1 ES 456134 A ES456134 A ES 456134A ES 456134 A ES456134 A ES 456134A ES 456134 A1 ES456134 A1 ES 456134A1
- Authority
- ES
- Spain
- Prior art keywords
- androstadiene
- carboxylic acid
- novel
- acid esters
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- JMDKZCFWCUZPPB-SWAWSRFWSA-N (8r,9s,10s,13s)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12-decahydro-1h-cyclopenta[a]phenanthrene-17-carboxylic acid Chemical class C([C@H]12)CC3CCCC[C@]3(C)[C@H]1CC[C@@]1(C)C2=CC=C1C(O)=O JMDKZCFWCUZPPB-SWAWSRFWSA-N 0.000 title abstract 2
- 239000000460 chlorine Substances 0.000 abstract 5
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- NYGWTZLABYSHOP-FCYODTKKSA-N (8R,9S,10S,13R)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12-decahydro-1H-cyclopenta[a]phenanthrene Chemical compound C([C@H]12)CC3CCCC[C@]3(C)[C@H]1CC[C@@]1(C)C2=CC=C1 NYGWTZLABYSHOP-FCYODTKKSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000037396 body weight Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 210000001541 thymus gland Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH225376A CH628355A5 (de) | 1976-02-24 | 1976-02-24 | Verfahren zur herstellung neuer androstadien-17beta-carbonsaeuren und ihrer ester und salze. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES456134A1 true ES456134A1 (es) | 1978-05-01 |
Family
ID=4229445
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES456134A Expired ES456134A1 (es) | 1976-02-24 | 1977-02-22 | Procedimiento para la obtencion de esteres de acidos andros-tadien-17-carboxilicos. |
| ES467434A Expired ES467434A1 (es) | 1976-02-24 | 1978-03-01 | Procedimiento para la obtencion de esteres de acidos andros-tadien-17-carboxilicos. |
| ES467432A Expired ES467432A1 (es) | 1976-02-24 | 1978-03-01 | Procedimiento para la obtencion de esteres de acidos andros-tadien-17-carboxilicos. |
| ES467433A Expired ES467433A1 (es) | 1976-02-24 | 1978-03-01 | Procedimiento para la obtencion de esteres de acidos andros-tadien-17-carboxilicos |
| ES467430A Expired ES467430A1 (es) | 1976-02-24 | 1978-03-01 | Procedimiento para la obtencion de esteres de acidos andros-tazdien-17-carboxilicos. |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES467434A Expired ES467434A1 (es) | 1976-02-24 | 1978-03-01 | Procedimiento para la obtencion de esteres de acidos andros-tadien-17-carboxilicos. |
| ES467432A Expired ES467432A1 (es) | 1976-02-24 | 1978-03-01 | Procedimiento para la obtencion de esteres de acidos andros-tadien-17-carboxilicos. |
| ES467433A Expired ES467433A1 (es) | 1976-02-24 | 1978-03-01 | Procedimiento para la obtencion de esteres de acidos andros-tadien-17-carboxilicos |
| ES467430A Expired ES467430A1 (es) | 1976-02-24 | 1978-03-01 | Procedimiento para la obtencion de esteres de acidos andros-tazdien-17-carboxilicos. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US4285937A (OSRAM) |
| JP (1) | JPS52102264A (OSRAM) |
| AT (1) | AT361141B (OSRAM) |
| AU (1) | AU513559B2 (OSRAM) |
| BE (1) | BE851725A (OSRAM) |
| CA (1) | CA1084483A (OSRAM) |
| CH (4) | CH628355A5 (OSRAM) |
| CY (1) | CY1198A (OSRAM) |
| DD (1) | DD145918A5 (OSRAM) |
| DE (1) | DE2707336A1 (OSRAM) |
| DK (1) | DK153493C (OSRAM) |
| ES (5) | ES456134A1 (OSRAM) |
| FR (2) | FR2342302A1 (OSRAM) |
| GB (1) | GB1578243A (OSRAM) |
| HK (1) | HK57483A (OSRAM) |
| HU (1) | HU176762B (OSRAM) |
| IE (1) | IE45023B1 (OSRAM) |
| IL (2) | IL51519A (OSRAM) |
| KE (1) | KE3300A (OSRAM) |
| MX (1) | MX9203366A (OSRAM) |
| MY (1) | MY8500017A (OSRAM) |
| NL (1) | NL7701886A (OSRAM) |
| NZ (1) | NZ183418A (OSRAM) |
| SE (1) | SE436572B (OSRAM) |
| SG (1) | SG37383G (OSRAM) |
| ZA (1) | ZA771087B (OSRAM) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT69411A (en) * | 1978-04-05 | 1979-04-01 | Syntex Inc | 4-halo etianic acids and derivatives thereof |
| US4198403A (en) * | 1978-04-05 | 1980-04-15 | Syntex (U.S.A.) Inc. | 17 Beta-thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes |
| US4188385A (en) * | 1978-04-05 | 1980-02-12 | Syntex (U.S.A.) Inc. | Thioetianic acid derivatives |
| DE3024008C2 (de) * | 1980-06-24 | 1982-04-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 17α-Hydroxy-etiocarbonsäuren |
| US4607028A (en) * | 1983-08-18 | 1986-08-19 | Ciba-Geigy Corporation | Novel carboxylic acid esters |
| SE8306370D0 (sv) * | 1983-11-18 | 1983-11-18 | Draco Ab | Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions |
| SE8501693D0 (sv) * | 1985-04-04 | 1985-04-04 | Draco Ab | Novel 16,17-acetalsubstituted androstane-17beta-carboxylic acid esters |
| IL78144A0 (en) * | 1985-04-04 | 1986-07-31 | Draco Ab | Novel androstane-17beta-carboxylic acid esters |
| AU5640390A (en) * | 1989-06-16 | 1991-01-08 | Upjohn Company, The | Suramin type compounds and angiostatic steroids to inhibit angiogenesis |
| US6596260B1 (en) | 1993-08-27 | 2003-07-22 | Novartis Corporation | Aerosol container and a method for storage and administration of a predetermined amount of a pharmaceutically active aerosol |
| US5646136A (en) * | 1994-01-04 | 1997-07-08 | Duke University | Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids |
| US5981517A (en) * | 1996-05-09 | 1999-11-09 | Soft Drugs, Inc. | Androstene derivatives |
| GB0015876D0 (en) * | 2000-06-28 | 2000-08-23 | Novartis Ag | Organic compounds |
| US6858593B2 (en) * | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| US6858596B2 (en) * | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
| US6759398B2 (en) * | 2000-08-05 | 2004-07-06 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative |
| US6777400B2 (en) * | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| US6750210B2 (en) * | 2000-08-05 | 2004-06-15 | Smithkline Beecham Corporation | Formulation containing novel anti-inflammatory androstane derivative |
| US6787532B2 (en) * | 2000-08-05 | 2004-09-07 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivatives |
| ES2523930T3 (es) * | 2000-08-05 | 2014-12-02 | Glaxo Group Limited | Éster s-fluorometílico del ácido 6-alfa,9-alfa-difluoro-17-alfa-[(2-furanilcarbonil)oxi]-11-beta-hidroxi-16-alfa-metil-3-oxo-androst-1,4-dien-17-carbotioico como agente antiinflamatorio |
| US6777399B2 (en) * | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| GB0019172D0 (en) * | 2000-08-05 | 2000-09-27 | Glaxo Group Ltd | Novel compounds |
| UA77656C2 (en) * | 2001-04-07 | 2007-01-15 | Glaxo Group Ltd | S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent |
| PT1383786E (pt) * | 2001-04-30 | 2008-12-30 | Glaxo Group Ltd | Derivados anti-inflamatórios de éster 17.beta-carbotioato de androstano com um grupo éster ciclíco na posição 17.alfa |
| US20050175545A1 (en) * | 2002-02-04 | 2005-08-11 | Keith Biggadike | Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist |
| GB0202635D0 (en) * | 2002-02-05 | 2002-03-20 | Glaxo Wellcome Mfg Pte Ltd | Formulation containing novel anti-inflammatory androstane derivative |
| GB2389530B (en) | 2002-06-14 | 2007-01-10 | Cipla Ltd | Pharmaceutical compositions |
| DE602004025002D1 (de) * | 2003-06-19 | 2010-02-25 | Nicholas S Bodor | Steigerung der aktivität und/oder der wirkungsdauer weicher steroide mit anti-entzündungswirkung für topische oder lokale verabreichung |
| EP1658083B1 (en) * | 2003-06-19 | 2007-08-08 | BODOR, Nicholas S. | Enhancement of activity and/or duration of action of selected anti-inflammatory steroids |
| GB0507165D0 (en) * | 2005-04-08 | 2005-05-18 | Glaxo Group Ltd | Novel crystalline pharmaceutical product |
| RU2008119322A (ru) * | 2005-10-19 | 2009-11-27 | Рэнбакси Лабораториз Лимитед (In) | Композиции ингибиторов фосфодиэстеразы iv типа |
| US7691811B2 (en) * | 2006-05-25 | 2010-04-06 | Bodor Nicholas S | Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye |
| US7687484B2 (en) * | 2006-05-25 | 2010-03-30 | Bodor Nicholas S | Transporter enhanced corticosteroid activity |
| GB0615108D0 (en) * | 2006-07-28 | 2006-09-06 | Glaxo Group Ltd | Novel formulations |
| US8227027B2 (en) * | 2007-12-07 | 2012-07-24 | Presspart Gmbh & Co. Kg | Method for applying a polymer coating to an internal surface of a container |
| EP2111861A1 (en) | 2008-04-21 | 2009-10-28 | Ranbaxy Laboratories Limited | Compositions of phosphodiesterase type IV inhibitors |
| US8835410B2 (en) | 2011-05-10 | 2014-09-16 | Bodor Laboratories, Inc. | Treatment of eyelid dermatitis |
| CN111100176A (zh) * | 2019-12-20 | 2020-05-05 | 重庆华邦胜凯制药有限公司 | 一种化合物的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3636010A (en) * | 1968-12-23 | 1972-01-18 | Ciba Geigy Corp | Esters of steroid-17-carboxylic acids |
| GB1384372A (en) * | 1971-01-20 | 1975-02-19 | Glaxo Lab Ltd | Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids |
| GB1438940A (en) * | 1972-07-19 | 1976-06-09 | Glaxo Lab Ltd | 17beta-haloalkoxycarbonyl-17alpha-oxysteroids |
| US4093721A (en) * | 1974-08-30 | 1978-06-06 | Glaxo Laboratories Limited | Pharmaceutical compositions of 6α,9α-difluoro-androst-4-ene-17β-carboxylates and derivatives thereof |
| GB1514476A (en) * | 1974-08-30 | 1978-06-14 | Glaxo Lab Ltd | Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates |
-
1976
- 1976-02-24 CH CH225376A patent/CH628355A5/de not_active IP Right Cessation
-
1977
- 1977-02-18 GB GB6955/77A patent/GB1578243A/en not_active Expired
- 1977-02-18 CY CY1198A patent/CY1198A/xx unknown
- 1977-02-19 DE DE19772707336 patent/DE2707336A1/de active Granted
- 1977-02-22 DD DD77197502A patent/DD145918A5/de unknown
- 1977-02-22 ES ES456134A patent/ES456134A1/es not_active Expired
- 1977-02-22 NL NL7701886A patent/NL7701886A/xx unknown
- 1977-02-22 FR FR7705053A patent/FR2342302A1/fr active Granted
- 1977-02-22 IL IL51519A patent/IL51519A/xx unknown
- 1977-02-22 CA CA272,291A patent/CA1084483A/en not_active Expired
- 1977-02-23 NZ NZ183418A patent/NZ183418A/xx unknown
- 1977-02-23 DK DK079077A patent/DK153493C/da not_active IP Right Cessation
- 1977-02-23 ZA ZA00771087A patent/ZA771087B/xx unknown
- 1977-02-23 AU AU22572/77A patent/AU513559B2/en not_active Expired
- 1977-02-23 AT AT119477A patent/AT361141B/de not_active IP Right Cessation
- 1977-02-23 SE SE7701999A patent/SE436572B/xx not_active IP Right Cessation
- 1977-02-23 BE BE175169A patent/BE851725A/xx not_active IP Right Cessation
- 1977-02-23 IE IE382/77A patent/IE45023B1/en not_active IP Right Cessation
- 1977-02-23 HU HU77CI1720A patent/HU176762B/hu unknown
- 1977-02-24 JP JP1874377A patent/JPS52102264A/ja active Granted
-
1978
- 1978-01-27 FR FR7802324A patent/FR2369297A1/fr active Granted
- 1978-03-01 ES ES467434A patent/ES467434A1/es not_active Expired
- 1978-03-01 ES ES467432A patent/ES467432A1/es not_active Expired
- 1978-03-01 ES ES467433A patent/ES467433A1/es not_active Expired
- 1978-03-01 ES ES467430A patent/ES467430A1/es not_active Expired
-
1979
- 1979-10-30 US US06/089,677 patent/US4285937A/en not_active Expired - Lifetime
-
1980
- 1980-11-19 IL IL61512A patent/IL61512A0/xx unknown
-
1981
- 1981-06-11 CH CH383381A patent/CH628641A5/de not_active IP Right Cessation
- 1981-06-11 CH CH383181A patent/CH629824A5/de not_active IP Right Cessation
- 1981-06-11 CH CH383281A patent/CH628356A5/de not_active IP Right Cessation
-
1983
- 1983-06-23 KE KE3300A patent/KE3300A/xx unknown
- 1983-06-27 SG SG373/83A patent/SG37383G/en unknown
- 1983-11-17 HK HK574/83A patent/HK57483A/xx unknown
-
1985
- 1985-12-30 MY MY17/85A patent/MY8500017A/xx unknown
-
1992
- 1992-06-25 MX MX9203366A patent/MX9203366A/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1A | Transfer granted |