ES455938A1 - Un procedimiento para la preparacion de nuevos derivados de biciclo (2,2,1) heptano. - Google Patents
Un procedimiento para la preparacion de nuevos derivados de biciclo (2,2,1) heptano.Info
- Publication number
- ES455938A1 ES455938A1 ES455938A ES455938A ES455938A1 ES 455938 A1 ES455938 A1 ES 455938A1 ES 455938 A ES455938 A ES 455938A ES 455938 A ES455938 A ES 455938A ES 455938 A1 ES455938 A1 ES 455938A1
- Authority
- ES
- Spain
- Prior art keywords
- endo
- alkyl
- indolecarbonyloxy
- bicyclo
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Nueva serie de imidas de ácido 5-endo-(3-indolcarboniloxi)-N-[aminoalquil (inferior)] biciclo [2.2.1] heptano-2, 3-di-endo carboxílico que poseen actividad anti-arrítmica y/o anti-fibrilatoria. La arritmia cardiaca, un fenómeno comúnmente asociado con las enfermedades cardiacas coronarias o con el infarto de miocardio. Se sospecha que el mecanismo de la arritmia cardiaca es causado por un "foco" anormal en el ventrículo del corazón que envía (enciende) señales nerviosas con mayor rapidez que la requerida para el latido normal del corazón. Se ha descubierto que la serie de compuestos aquí denominados imidas de ácido 5-endo (3-indolcarboniloxi)-N-[aminoalquil (inferior)]biciclo[2.2.1] heptano-2,3-di-endo-carboxílico son agentes terapéuticos o profilácticos útiles para suprimir el latido ectópico anormal.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50702974A | 1974-09-18 | 1974-09-18 | |
| US05/594,918 US3980668A (en) | 1974-09-18 | 1975-07-10 | Anti-arrhythimic 5-endo-(3-indolecarbonyloxy)-N-[amino-(lower)alkyl]bicyclo[2,2,1]heptane-2,3-di-endo-carboxylic acid imides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES455938A1 true ES455938A1 (es) | 1978-02-01 |
Family
ID=27055675
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES441038A Expired ES441038A1 (es) | 1974-09-18 | 1975-09-17 | Un procedimiento para la preparacion de nuevos derivados de biciclo (2, 2, 1) heptano. |
| ES455938A Expired ES455938A1 (es) | 1974-09-18 | 1977-02-15 | Un procedimiento para la preparacion de nuevos derivados de biciclo (2,2,1) heptano. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES441038A Expired ES441038A1 (es) | 1974-09-18 | 1975-09-17 | Un procedimiento para la preparacion de nuevos derivados de biciclo (2, 2, 1) heptano. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US3980668A (es) |
| JP (1) | JPS6039669B2 (es) |
| AR (1) | AR212235A1 (es) |
| AT (1) | AT345275B (es) |
| CA (1) | CA1068281A (es) |
| CH (1) | CH615925A5 (es) |
| CS (1) | CS187489B2 (es) |
| DD (1) | DD123092A5 (es) |
| DE (1) | DE2541434A1 (es) |
| DK (1) | DK418075A (es) |
| ES (2) | ES441038A1 (es) |
| FI (1) | FI64352C (es) |
| FR (1) | FR2313047A1 (es) |
| GB (1) | GB1484214A (es) |
| HU (1) | HU173807B (es) |
| IE (1) | IE42051B1 (es) |
| IL (1) | IL48096A (es) |
| LU (1) | LU73418A1 (es) |
| NL (1) | NL7510934A (es) |
| NO (1) | NO144072C (es) |
| PH (1) | PH11498A (es) |
| PL (2) | PL101454B1 (es) |
| SE (1) | SE421421B (es) |
| YU (2) | YU40123B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2557341A1 (de) * | 1975-12-19 | 1977-06-30 | Hoechst Ag | Basisch substituierte indolderivate und verfahren zu ihrer herstellung |
| US4139533A (en) * | 1976-08-19 | 1979-02-13 | Bristol-Myers Company | Bicyclo[2,2,1]heptane-2,3-diendo carboxylic acid imide esters of quinoline carboxylic acid |
| GB8814277D0 (en) * | 1988-06-16 | 1988-07-20 | Glaxo Group Ltd | Chemical compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3850921A (en) * | 1972-09-20 | 1974-11-26 | I Matuo | Derivatives of 2,3-norbornanedicarboxamide |
-
1975
- 1975-07-10 US US05/594,918 patent/US3980668A/en not_active Expired - Lifetime
- 1975-09-04 YU YU2253/75A patent/YU40123B/xx unknown
- 1975-09-09 CA CA235,093A patent/CA1068281A/en not_active Expired
- 1975-09-12 IL IL48096A patent/IL48096A/xx unknown
- 1975-09-15 NO NO753128A patent/NO144072C/no unknown
- 1975-09-15 FI FI752572A patent/FI64352C/fi not_active IP Right Cessation
- 1975-09-16 SE SE7510362A patent/SE421421B/xx unknown
- 1975-09-16 IE IE2022/75A patent/IE42051B1/en unknown
- 1975-09-17 FR FR7528529A patent/FR2313047A1/fr active Granted
- 1975-09-17 GB GB38221/75A patent/GB1484214A/en not_active Expired
- 1975-09-17 PH PH17583A patent/PH11498A/en unknown
- 1975-09-17 CS CS756301A patent/CS187489B2/cs unknown
- 1975-09-17 DK DK418075A patent/DK418075A/da not_active Application Discontinuation
- 1975-09-17 NL NL7510934A patent/NL7510934A/xx not_active Application Discontinuation
- 1975-09-17 LU LU73418A patent/LU73418A1/xx unknown
- 1975-09-17 PL PL1975201921A patent/PL101454B1/pl unknown
- 1975-09-17 DE DE19752541434 patent/DE2541434A1/de not_active Withdrawn
- 1975-09-17 ES ES441038A patent/ES441038A1/es not_active Expired
- 1975-09-17 PL PL1975183375A patent/PL100522B1/pl unknown
- 1975-09-18 JP JP50112199A patent/JPS6039669B2/ja not_active Expired
- 1975-09-18 HU HU75BI522A patent/HU173807B/hu unknown
- 1975-09-18 AR AR260435A patent/AR212235A1/es active
- 1975-09-18 CH CH1210375A patent/CH615925A5/de not_active IP Right Cessation
- 1975-09-18 AT AT718575A patent/AT345275B/de active
- 1975-09-18 DD DD188433A patent/DD123092A5/xx unknown
-
1977
- 1977-02-15 ES ES455938A patent/ES455938A1/es not_active Expired
-
1982
- 1982-12-21 YU YU02840/82A patent/YU284082A/xx unknown
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