GB2011407A - 4-oxo-nitrogen bridgehead compounds - Google Patents

4-oxo-nitrogen bridgehead compounds

Info

Publication number
GB2011407A
GB2011407A GB7850105A GB7850105A GB2011407A GB 2011407 A GB2011407 A GB 2011407A GB 7850105 A GB7850105 A GB 7850105A GB 7850105 A GB7850105 A GB 7850105A GB 2011407 A GB2011407 A GB 2011407A
Authority
GB
United Kingdom
Prior art keywords
alkyl
alkoxycarbonyl
phenyl
optionally substituted
nitrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7850105A
Other versions
GB2011407B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of GB2011407A publication Critical patent/GB2011407A/en
Application granted granted Critical
Publication of GB2011407B publication Critical patent/GB2011407B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

Nitrogen bridgehead compounds of the general formula (I> <IMAGE> [wherein R is H, alkyl or alkoxycarbonyl R<1> is H or alkyl; or R and R<1> together form -(CH=CH)2- R<2> is H, halogen, alkyl, phenyl or a 5- or 6-membered heterocyclic saturated ring, R<3> is H, optionally substituted phenyl, acyl, carboxy, alkoxycarbonyl -CN, carbamoyl, alkylcarbamoyl, alkyl, alkanoylcarbamoyl, acid- hydrazido, or -CO-NH-N=C (R<12> R<13>) (wherein R<12> and R<13>) are alkyl, carboxyalkyl, alkoxycarbonyl-alkyl or phenyl) or R<2> and R<3> form -(CH2)t (t is 3 or 4> Z is oxygen and n is 0, 1 or 2 and a) if R<11> is H and R<9>-R<10> and R<7>-R<8> form chemical bonds then R<4> is H or phenyl, YR<5>R<6> represents oxygen or Y represents nitrogen and R<5> is alkyl optionally substituted by hydroxy, carboxy or alkoxycarbonyl or phenyl optionally substituted by nitro, alkyl, alkoxycarbonyl and/or halogen; mono- or bi-cyclic nitrogen-containing heteroaryl, hydroxy aminothiocarbonyl, aminothiocarbonylamino or phenylamino, R<6> represents an unshared electron- pair, or H or alkyl, and in these two cases a salt is formed or R<5> and R<6> form -(CH2)p- (p is 4 or 5) and a salt is formed with N+ or b) if R<9> is H and R<10>-R<11> and R<8>-R<7> form chemical bonds, then R<4>, R<5>, R<6> and Y are as given under item (a); or c) if R<8>-R<9> and R<10>-R<11> form chemical bonds, then R<4> is H or phenyl, YR<5>R<6>R<7> represents halogen, or YR<6>R<7> represents oxygen and R<5> is H or alkyl; or YR<6>R<7> represents sulfur and R<5> is cyano; or Y represents nitrogen and R<5> is alkyl optionally substituted by hydroxy, carboxy, or alkoxycarbonyl; phenyl optionally substituted by nitro, C1-4alkyl, alkoxycarbonyl and/or halogen; or mono- or bicyclic nitrogen containing heteroaryl, R<6> is H or alkyl, or R<4> and R<6> form -(CH2)m- (m is 3 or 4) or R<5> and R<6> form -(CH2)p- (p is 4 or 5) and R<7> represents an unshared pair of electrons] and the tautomers and salts thereof. The novel compounds possess physiological activity.
GB7850105A 1977-12-29 1978-12-28 Nitrogen bridgehead compounds the salts thereof processes for their preparation and pharmaceutical compositions containing them Expired GB2011407B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU77CI1792A HU184058B (en) 1977-12-29 1977-12-29 Process for preparing new compounds with nitrogen bridge head

Publications (2)

Publication Number Publication Date
GB2011407A true GB2011407A (en) 1979-07-11
GB2011407B GB2011407B (en) 1982-09-08

Family

ID=10994681

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7850105A Expired GB2011407B (en) 1977-12-29 1978-12-28 Nitrogen bridgehead compounds the salts thereof processes for their preparation and pharmaceutical compositions containing them

Country Status (8)

Country Link
JP (1) JPS54109997A (en)
BE (1) BE873192A (en)
CH (1) CH641179A5 (en)
DE (1) DE2854114A1 (en)
FR (1) FR2413387A1 (en)
GB (1) GB2011407B (en)
HU (1) HU184058B (en)
SU (2) SU1181546A3 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0242230A2 (en) * 1986-04-16 1987-10-21 Tokyo Tanabe Company Limited Pyrido [1,2-a] pyrimidine derivatives
WO2005061501A2 (en) * 2003-12-12 2005-07-07 Merck & Co., Inc. Process for preparing hexahydropyrimido[1,2-a]azepine-2-carboxylates and related compounds

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4310526A (en) 1979-05-08 1982-01-12 Farmitalia Carlo Erba S.P.A. Substituted 6,7-methylene pyrido[1,2-a]pyrimidines useful as anti-allergic and anti-ulcer agents

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU174693B (en) * 1976-02-12 1980-03-28 Chinoin Gyogyszer Es Vegyeszet Process for producing condensed pyrimidine derivatives

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0242230A2 (en) * 1986-04-16 1987-10-21 Tokyo Tanabe Company Limited Pyrido [1,2-a] pyrimidine derivatives
EP0242230A3 (en) * 1986-04-16 1989-01-11 Tokyo Tanabe Company Limited Pyrido û1,2-a¨ pyrimidine derivatives
WO2005061501A2 (en) * 2003-12-12 2005-07-07 Merck & Co., Inc. Process for preparing hexahydropyrimido[1,2-a]azepine-2-carboxylates and related compounds
WO2005061501A3 (en) * 2003-12-12 2006-04-06 Merck & Co Inc Process for preparing hexahydropyrimido[1,2-a]azepine-2-carboxylates and related compounds

Also Published As

Publication number Publication date
SU1245260A3 (en) 1986-07-15
DE2854114A1 (en) 1979-07-12
GB2011407B (en) 1982-09-08
FR2413387A1 (en) 1979-07-27
SU1181546A3 (en) 1985-09-23
CH641179A5 (en) 1984-02-15
HU184058B (en) 1984-06-28
BE873192A (en) 1979-04-17
JPS54109997A (en) 1979-08-29
FR2413387B1 (en) 1982-10-29

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee