EP0242230A3 - Pyrido û1,2-a¨ pyrimidine derivatives - Google Patents

Pyrido û1,2-a¨ pyrimidine derivatives Download PDF

Info

Publication number
EP0242230A3
EP0242230A3 EP87303424A EP87303424A EP0242230A3 EP 0242230 A3 EP0242230 A3 EP 0242230A3 EP 87303424 A EP87303424 A EP 87303424A EP 87303424 A EP87303424 A EP 87303424A EP 0242230 A3 EP0242230 A3 EP 0242230A3
Authority
EP
European Patent Office
Prior art keywords
pyrido
pyrimidine derivatives
anaphylaxis
useable
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP87303424A
Other versions
EP0242230A2 (en
EP0242230B1 (en
Inventor
Naoto Matsuishi
Michiaki Amano
Yoshio Nakagawa
Norihiko Kakehi
Toshio 2-19-310 Washimiyadanchi Kawashima
Shigeki C/O Setagaya's Company Omura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tokyo Tanabe Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokyo Tanabe Co Ltd filed Critical Tokyo Tanabe Co Ltd
Publication of EP0242230A2 publication Critical patent/EP0242230A2/en
Publication of EP0242230A3 publication Critical patent/EP0242230A3/en
Application granted granted Critical
Publication of EP0242230B1 publication Critical patent/EP0242230B1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Numerical Control (AREA)
  • Adornments (AREA)

Abstract

Pyrido[1,2-a]pyrimidine derivatives of the general formula [I] and their physiologically acceptable salts are provided: <CHEM> where R is a hydrogen atom, a halogen atom or a methyl group, and n is 0, 1 or 2. The pyrido[1,2-a]pyrimidine derivatives and their salts exhibit an excellent antagonistic effect on the slow-reacting substance of anaphylaxis and, therefore, are useable for the treatment of allergic diseases.
EP87303424A 1986-04-16 1987-04-16 Pyrido [1,2-a] pyrimidine derivatives Expired - Lifetime EP0242230B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP86034/86 1986-04-16
JP61086034A JPS62242682A (en) 1986-04-16 1986-04-16 Novel pyrido(1,2-a)pyrimidine derivative

Publications (3)

Publication Number Publication Date
EP0242230A2 EP0242230A2 (en) 1987-10-21
EP0242230A3 true EP0242230A3 (en) 1989-01-11
EP0242230B1 EP0242230B1 (en) 1990-10-03

Family

ID=13875382

Family Applications (1)

Application Number Title Priority Date Filing Date
EP87303424A Expired - Lifetime EP0242230B1 (en) 1986-04-16 1987-04-16 Pyrido [1,2-a] pyrimidine derivatives

Country Status (9)

Country Link
US (1) US4798832A (en)
EP (1) EP0242230B1 (en)
JP (2) JPS62242682A (en)
AT (1) ATE57185T1 (en)
AU (1) AU601723B2 (en)
CA (1) CA1286665C (en)
DE (1) DE3765285D1 (en)
ES (1) ES2031889T3 (en)
GR (1) GR3000930T3 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0311016A (en) * 1989-06-09 1991-01-18 Tokyo Tanabe Co Ltd Aqueous preparation of pyrido(1,2-a)pyrimidine derivative
AU633584B2 (en) * 1989-06-15 1993-02-04 Tokyo Tanabe Company Limited Aerosols of pyrido(1,2-a)pyrimidine compounds
JPH0386825A (en) * 1989-06-15 1991-04-11 Tokyo Tanabe Co Ltd Aerosol agent of pyrido(1,2-a)pyrimidine derivative
JPH05339150A (en) * 1992-06-05 1993-12-21 Tokyo Tanabe Co Ltd Composition of pyrido [1,2-a pyrimidine derivative for oral administration]

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2182977A1 (en) * 1972-04-17 1973-12-14 Squibb & Sons Inc
GB2011407A (en) * 1977-12-29 1979-07-11 Chinoin Gyogyszer Es Vegyeszet 4-oxo-nitrogen bridgehead compounds
US4209620A (en) * 1978-06-19 1980-06-24 Bristol-Myers Company Substituted 3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives having antiallergy activity
EP0217673A1 (en) * 1985-10-03 1987-04-08 Tokyo Tanabe Company Limited Pyrido [1,2-a]pyrimidine derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1583691A (en) * 1977-01-26 1981-01-28 Fisons Ltd Benzopyrans
US4122274A (en) * 1977-05-25 1978-10-24 Bristol-Myers Company 3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones
JPS57206920A (en) * 1981-06-15 1982-12-18 Yamazaki Mazak Corp Numerically controlled machine tool
US4661505A (en) * 1982-11-03 1987-04-28 Eli Lilly And Company Leukotriene antagonists
US4667055A (en) * 1983-12-29 1987-05-19 Merck Frosst Canada, Inc. Leukotriene antagonists
US4617407A (en) * 1984-08-30 1986-10-14 Merck Frosst Canada, Inc. Leukotriene antagonists

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2182977A1 (en) * 1972-04-17 1973-12-14 Squibb & Sons Inc
GB2011407A (en) * 1977-12-29 1979-07-11 Chinoin Gyogyszer Es Vegyeszet 4-oxo-nitrogen bridgehead compounds
US4209620A (en) * 1978-06-19 1980-06-24 Bristol-Myers Company Substituted 3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives having antiallergy activity
EP0217673A1 (en) * 1985-10-03 1987-04-08 Tokyo Tanabe Company Limited Pyrido [1,2-a]pyrimidine derivatives

Also Published As

Publication number Publication date
JPH01193223A (en) 1989-08-03
ATE57185T1 (en) 1990-10-15
CA1286665C (en) 1991-07-23
GR3000930T3 (en) 1991-12-10
DE3765285D1 (en) 1990-11-08
AU601723B2 (en) 1990-09-20
JPH0615472B2 (en) 1994-03-02
US4798832A (en) 1989-01-17
JPH0374669B2 (en) 1991-11-27
JPS62242682A (en) 1987-10-23
EP0242230A2 (en) 1987-10-21
AU7109787A (en) 1987-10-22
EP0242230B1 (en) 1990-10-03
ES2031889T3 (en) 1993-01-01

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