GB1500054A - 5-fluorouracil derivatives and preparation thereof - Google Patents

5-fluorouracil derivatives and preparation thereof

Info

Publication number
GB1500054A
GB1500054A GB1992375A GB1992375A GB1500054A GB 1500054 A GB1500054 A GB 1500054A GB 1992375 A GB1992375 A GB 1992375A GB 1992375 A GB1992375 A GB 1992375A GB 1500054 A GB1500054 A GB 1500054A
Authority
GB
United Kingdom
Prior art keywords
hydrogen
fluorouracil
preparation
alkyl
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1992375A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to GB1992375A priority Critical patent/GB1500054A/en
Publication of GB1500054A publication Critical patent/GB1500054A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1500054 5-Fluorouracil derivatives ONO PHARMACEUTICAL CO Ltd 12 May 1975 19923/75 Heading C2C Novel compounds of the Formula I wherein R is hydrogen or a -CA 1 A 2 A 3 radical provided that the two R's are not hydrogen simultaneously, and A 1 , A 2 and A 3 are the same or different radicals and are selected from hydrogen, alkyl or optionally substituted alkoxy or aryloxy, acyl, carboxy, or optionally substituted earbalkoxy or carbonyloxy, provided that at least one of A 1 , A 2 and A 3 is a radical other than hydrogen and alkyl, and at least one of A 1 , A 2 and A 3 is hydrogen, may be prepared by reacting 5-fluorouracil with X-CA 1 A 2 A 3 where X is halo, in the presence of a base. The compounds I are pharmaceutically active as anti-tumour agents.
GB1992375A 1975-05-12 1975-05-12 5-fluorouracil derivatives and preparation thereof Expired GB1500054A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1992375A GB1500054A (en) 1975-05-12 1975-05-12 5-fluorouracil derivatives and preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1992375A GB1500054A (en) 1975-05-12 1975-05-12 5-fluorouracil derivatives and preparation thereof

Publications (1)

Publication Number Publication Date
GB1500054A true GB1500054A (en) 1978-02-08

Family

ID=10137396

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1992375A Expired GB1500054A (en) 1975-05-12 1975-05-12 5-fluorouracil derivatives and preparation thereof

Country Status (1)

Country Link
GB (1) GB1500054A (en)

Similar Documents

Publication Publication Date Title
NZ233735A (en) Heterocyclic substituted aminophenol derivatives
JPS5331676A (en) Uracil derivatives and their preparation
ES447010A1 (en) Anti-diarrheal compounds
IE38979B1 (en) Amides derived from quinoxaline
ES468170A1 (en) 14-Amino derivatives of morphine, methods of making them and analgesic compositions containing them
ES457805A1 (en) Thiourea derivatives
ES466192A1 (en) Isoquinoline derivatives and pharmaceutical compositions containing them
GB1500054A (en) 5-fluorouracil derivatives and preparation thereof
ES448781A1 (en) Mixed hydroxymethyl-hydroxyalkyl isocyanurates
JPS5424862A (en) Norbornane and norbornene derivatives
JPS5273878A (en) Synthesis of 6-carboxyacetyl-3,4-dihydrocarbostyril
JPS5266626A (en) Non-medical fungicide and anti-phytophagineae agent, and their prepara tion
JPS5239674A (en) Imidazole derivatives and agricultural bactericides therefrom
JPS5427578A (en) 1-carboxyalkylcarbamoyl-5-fluorouracil derivatives and their preparation
ES433081A1 (en) 1{40 ,4{40 -Dihydro-1-methyl-spiro{8 piperidine and pyrolidine-2,3{40 (2{40 H)quinoline{9 {0 compounds
FR2361364A1 (en) NEW DERIVATIVES OF AZETIDINE
JPS525795A (en) Preparation of tetrahydro pyridopyrimidinone derivatives
ES435329A1 (en) 2,3,8,12b-tetrahydro-1h-3a 8-methanodibenzo-3,4,6,7-cyclohepta -1,2-c-pyrrole and derivatives thereof
JPS5242888A (en) Preparation of quinazoline derivatives
JPS5340746A (en) Organophosphorous compound and chlorine-containing resin composition
JPS5439046A (en) Novel derivatives of antibiotics xk-62-2 and their preparation
JPS52134634A (en) 3,10-dialkoxy-4-halogeno-13-cyanotriphenodioxazines
JPS525796A (en) Preparation of tetrahydropyrido pyrimidinone derivatives
ES464753A1 (en) D-6-allyl-8-ergol-I-ylacetamide
JPS524818A (en) Speaker

Legal Events

Date Code Title Description
PS Patent sealed
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19950511