ES453853A1 - Metodo para producir nuevos derivados del acido fusidico. - Google Patents
Metodo para producir nuevos derivados del acido fusidico.Info
- Publication number
- ES453853A1 ES453853A1 ES453853A ES453853A ES453853A1 ES 453853 A1 ES453853 A1 ES 453853A1 ES 453853 A ES453853 A ES 453853A ES 453853 A ES453853 A ES 453853A ES 453853 A1 ES453853 A1 ES 453853A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- compounds
- radical
- oxygen
- sulphur
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
Método para producir nuevos derivados del ácido fusidico, que responde a la formula general I **(Fórmula)** fórmula en la que la línea de puntos ente C-24 y C-25 indica que los átomos de carbono en cuestión están conectados bien sea por un enlace doble o bien por un enlace sencillo, y el asterisco de C-20 indica que los compuestos existen en dos formas diastereómeras; y en dicha fórmula A representa oxígeno o azufre, y R1 representa un radical alquilo lineal o ramificado, sin sustituir o sustituido que tiene de 1 a 12 átomos de carbono, un radical alquenilo o alquinilo que tiene de 2 a 6 átomos de carbono, un radical cicloalquilo sin sustituir o sustituido que tiene de 3 a 7 átomos de carbono en el anillo aliciclico, un radical aralquilo o arilo sin sustituir o sustituido; o un radical heterocíclico que tiene 5 ó 6 átomos en el anillo y que contiene átomos de oxígeno, azufre y/o nitrógeno; los diastereómeros puros de los compuestos de fórmula I y sus mezclas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB49714/75A GB1565954A (en) | 1975-12-03 | 1975-12-03 | Fusidic acid derivatives |
| GB1601576 | 1976-04-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES453853A1 true ES453853A1 (es) | 1978-01-16 |
Family
ID=26251702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES453853A Expired ES453853A1 (es) | 1975-12-03 | 1976-12-01 | Metodo para producir nuevos derivados del acido fusidico. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US4100276A (es) |
| JP (1) | JPS5271459A (es) |
| AT (1) | AT343810B (es) |
| AU (1) | AU501066B2 (es) |
| CA (1) | CA1079267A (es) |
| DE (1) | DE2654508A1 (es) |
| DK (1) | DK142852B (es) |
| ES (1) | ES453853A1 (es) |
| FI (1) | FI57599C (es) |
| FR (1) | FR2333807A1 (es) |
| GR (1) | GR62007B (es) |
| IE (1) | IE44263B1 (es) |
| IT (1) | IT1074295B (es) |
| LU (1) | LU76313A1 (es) |
| NL (1) | NL7613445A (es) |
| NZ (1) | NZ182661A (es) |
| PT (1) | PT65925B (es) |
| SE (1) | SE410859B (es) |
| SU (1) | SU679146A3 (es) |
| YU (1) | YU291176A (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE44263B1 (en) * | 1975-12-03 | 1981-09-23 | Leo Pharm Prod Ltd | New fusidic acid derivatives |
| US4162259A (en) * | 1975-12-03 | 1979-07-24 | Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske fabrik Produktionsaktienselskab) | Fusidic acid derivatives |
| US4746508A (en) * | 1983-06-06 | 1988-05-24 | Beth Israel Hospital Assn. | Drug administration |
| US4548922A (en) * | 1983-06-06 | 1985-10-22 | Beth Israel Hospital | Drug administration |
| US4959358A (en) * | 1983-06-06 | 1990-09-25 | Beth Israel Hospital Assn. | Drug administration |
| US6255299B1 (en) * | 1985-01-07 | 2001-07-03 | Leo Pharmaceutical Products Ltd. | Opthalmic gel composition and method of treating eye infections |
| GB8500310D0 (en) * | 1985-01-07 | 1985-02-13 | Leo Pharm Prod Ltd | Pharmaceutical preparation |
| GB8706313D0 (en) * | 1987-03-17 | 1987-04-23 | Health Lab Service Board | Treatment & prevention of viral infections |
| US4994439A (en) * | 1989-01-19 | 1991-02-19 | California Biotechnology Inc. | Transmembrane formulations for drug administration |
| US5372996A (en) * | 1989-03-10 | 1994-12-13 | Endorecherche, Inc. | Method of treatment of androgen-related diseases |
| JP2959839B2 (ja) * | 1989-07-07 | 1999-10-06 | アンドルシェルシュ・インコーポレイテッド | 性ステロイド活性の抑制における使用のためのアンドロゲン誘導体 |
| KR920703065A (ko) * | 1989-07-07 | 1992-12-17 | 원본미기재 | 안드로겐 관련질병의 치료방법 |
| RU2141967C1 (ru) * | 1992-05-21 | 1999-11-27 | Андорешерш Инк. | ИНГИБИТОРЫ ТЕСТОСТЕРОН 5α-РЕДУКТАЗЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ИНГИБИРОВАНИЯ АКТИВНОСТИ ТЕСТОСТЕРОН 5α-РЕДУКТАЗЫ |
| US5454801A (en) * | 1992-10-09 | 1995-10-03 | Mcneil-Ppc, Inc. | Printed polymer coatings and method for making same |
| US5658560A (en) * | 1994-01-18 | 1997-08-19 | Serikov; Vladimir B. | Method of treating endotoxemia by administering tyloxapol |
| MY140194A (en) * | 2003-07-16 | 2009-11-30 | Leo Pharma As | Novel fusidic acid derivatives |
| US20080161324A1 (en) * | 2006-09-14 | 2008-07-03 | Johansen Lisa M | Compositions and methods for treatment of viral diseases |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1447489A (en) * | 1972-10-06 | 1976-08-25 | Leo Pharm Prod Ltd | Fusidic acid conjugates |
| GB1490852A (en) * | 1974-09-12 | 1977-11-02 | Leo Pharm Prod Ltd | Fusidic acid derivatives |
| IE44263B1 (en) * | 1975-12-03 | 1981-09-23 | Leo Pharm Prod Ltd | New fusidic acid derivatives |
-
1976
- 1976-11-16 IE IE2521/76A patent/IE44263B1/en unknown
- 1976-11-18 NZ NZ182661A patent/NZ182661A/xx unknown
- 1976-11-22 AU AU19868/76A patent/AU501066B2/en not_active Expired
- 1976-11-24 US US05/744,978 patent/US4100276A/en not_active Expired - Lifetime
- 1976-11-30 GR GR52285A patent/GR62007B/el unknown
- 1976-12-01 IT IT69872/76A patent/IT1074295B/it active
- 1976-12-01 AT AT887576A patent/AT343810B/de not_active IP Right Cessation
- 1976-12-01 DE DE19762654508 patent/DE2654508A1/de not_active Withdrawn
- 1976-12-01 DK DK539476AA patent/DK142852B/da unknown
- 1976-12-01 YU YU02911/76A patent/YU291176A/xx unknown
- 1976-12-01 FR FR7636247A patent/FR2333807A1/fr active Granted
- 1976-12-01 ES ES453853A patent/ES453853A1/es not_active Expired
- 1976-12-02 SE SE7613565A patent/SE410859B/sv unknown
- 1976-12-02 FI FI763473A patent/FI57599C/fi not_active IP Right Cessation
- 1976-12-02 NL NL7613445A patent/NL7613445A/xx not_active Application Discontinuation
- 1976-12-02 LU LU76313A patent/LU76313A1/xx unknown
- 1976-12-02 CA CA266,994A patent/CA1079267A/en not_active Expired
- 1976-12-02 PT PT65925A patent/PT65925B/pt unknown
- 1976-12-02 JP JP51144065A patent/JPS5271459A/ja active Pending
- 1976-12-02 SU SU762425974A patent/SU679146A3/ru active
-
1979
- 1979-05-31 US US06/044,163 patent/US4315004A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NL7613445A (nl) | 1977-06-07 |
| JPS5271459A (en) | 1977-06-14 |
| SE410859B (sv) | 1979-11-12 |
| DK539476A (es) | 1977-06-04 |
| US4315004A (en) | 1982-02-09 |
| ATA887576A (de) | 1977-10-15 |
| AT343810B (de) | 1978-06-26 |
| IT1074295B (it) | 1985-04-20 |
| FI763473A (es) | 1977-06-04 |
| LU76313A1 (es) | 1977-06-21 |
| PT65925A (en) | 1977-01-01 |
| YU291176A (en) | 1982-05-31 |
| NZ182661A (en) | 1979-07-11 |
| GR62007B (en) | 1979-02-15 |
| FR2333807B1 (es) | 1980-11-07 |
| PT65925B (en) | 1978-06-13 |
| IE44263L (en) | 1977-06-03 |
| FI57599C (fi) | 1980-09-10 |
| DK142852B (da) | 1981-02-09 |
| DE2654508A1 (de) | 1977-06-08 |
| SE7613565L (sv) | 1977-06-04 |
| AU501066B2 (en) | 1979-06-07 |
| DK142852C (es) | 1981-09-21 |
| AU1986876A (en) | 1978-06-01 |
| US4100276A (en) | 1978-07-11 |
| SU679146A3 (ru) | 1979-08-05 |
| IE44263B1 (en) | 1981-09-23 |
| CA1079267A (en) | 1980-06-10 |
| FR2333807A1 (fr) | 1977-07-01 |
| FI57599B (fi) | 1980-05-30 |
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