ES446083A1 - Procedimiento para la obtencion de derivados del 2-hidroxi-3-aminopropano de actividad beta-receptora. - Google Patents
Procedimiento para la obtencion de derivados del 2-hidroxi-3-aminopropano de actividad beta-receptora.Info
- Publication number
- ES446083A1 ES446083A1 ES446083A ES446083A ES446083A1 ES 446083 A1 ES446083 A1 ES 446083A1 ES 446083 A ES446083 A ES 446083A ES 446083 A ES446083 A ES 446083A ES 446083 A1 ES446083 A1 ES 446083A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- amino
- case
- lower alkyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004076 pyridyl group Chemical group 0.000 title abstract 4
- -1 Pyridazinyl,pyrimidinyl,pyrazinyl Chemical group 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 40
- 125000004432 carbon atom Chemical group C* 0.000 abstract 32
- 125000003545 alkoxy group Chemical group 0.000 abstract 14
- 229910052736 halogen Inorganic materials 0.000 abstract 12
- 150000002367 halogens Chemical class 0.000 abstract 12
- 125000003342 alkenyl group Chemical group 0.000 abstract 9
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 9
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 8
- 125000004849 alkoxymethyl group Chemical group 0.000 abstract 7
- 125000002947 alkylene group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 6
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 5
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 3
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 3
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 3
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- HXKKHQJGJAFBHI-UHFFFAOYSA-N 1-aminopropan-2-ol Chemical class CC(O)CN HXKKHQJGJAFBHI-UHFFFAOYSA-N 0.000 abstract 1
- 150000001335 aliphatic alkanes Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000005237 alkyleneamino group Chemical group 0.000 abstract 1
- 102000012740 beta Adrenergic Receptors Human genes 0.000 abstract 1
- 108010079452 beta Adrenergic Receptors Proteins 0.000 abstract 1
- 125000005242 carbamoyl alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH244473A CH584209A5 (en) | 1973-02-20 | 1973-02-20 | 3-amino-2-hydroxypropoxy substd. diazines and pyridines - with beta-adrenergic blocking or stimulating activity |
| FI193/74A FI60391C (fi) | 1973-02-20 | 1974-01-23 | Analogifoerfarande foer framstaellning av beta-reseptor-aktiva 1-heterocyklyloxi-3-amino-2-propanolfoereningar |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES446083A1 true ES446083A1 (es) | 1977-09-16 |
Family
ID=25690464
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES446083A Expired ES446083A1 (es) | 1973-02-20 | 1976-03-16 | Procedimiento para la obtencion de derivados del 2-hidroxi-3-aminopropano de actividad beta-receptora. |
| ES76446081A Expired ES446081A1 (es) | 1973-02-20 | 1976-03-16 | Procedimiento para la obtencion de derivados del 2-hidroxi-3-aminopropano de actividad beta-receptora. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES76446081A Expired ES446081A1 (es) | 1973-02-20 | 1976-03-16 | Procedimiento para la obtencion de derivados del 2-hidroxi-3-aminopropano de actividad beta-receptora. |
Country Status (15)
| Country | Link |
|---|---|
| AR (6) | AR206801A1 (enExample) |
| AT (1) | AT335455B (enExample) |
| BE (1) | BE811274A (enExample) |
| CA (1) | CA1027131A (enExample) |
| CS (1) | CS203970B2 (enExample) |
| DD (1) | DD110041A5 (enExample) |
| DE (1) | DE2406930A1 (enExample) |
| DK (1) | DK143501C (enExample) |
| ES (2) | ES446083A1 (enExample) |
| FR (1) | FR2218101B1 (enExample) |
| GB (1) | GB1465946A (enExample) |
| IE (1) | IE38839B1 (enExample) |
| IL (1) | IL44202A (enExample) |
| LU (1) | LU69415A1 (enExample) |
| SE (1) | SE420834B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4195090A (en) * | 1973-02-20 | 1980-03-25 | Ciba-Geigy Corporation | 2-(3-Amino-2-hydroxy-propoxy)pyridine derivatives and pharmaceutical compositions therewith |
| US4000282A (en) * | 1974-12-16 | 1976-12-28 | Merck & Co., Inc. | 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines |
| JPS5283759A (en) * | 1976-01-01 | 1977-07-12 | Merck & Co Inc | Substituted pyridines |
| US4060601A (en) * | 1976-06-15 | 1977-11-29 | Merck & Co., Inc. | Certain lower-alkyl amino-2'-hydroxy-propoxy pyridines |
| US4091104A (en) * | 1976-06-15 | 1978-05-23 | Merck & Co., Inc. | Substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines, their preparation and use |
| US4092419A (en) * | 1976-06-15 | 1978-05-30 | Merck & Co., Inc. | Substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines, their preparation and use |
| DE2711655A1 (de) * | 1977-03-17 | 1978-09-21 | Basf Ag | Pyridinyl-aminoalkylaether |
| US4166851A (en) * | 1977-05-16 | 1979-09-04 | Merck & Co., Inc. | Certain imidazo(1,2a)pyridine derivatives |
| US4753673A (en) * | 1977-07-22 | 1988-06-28 | The Dow Chemical Company | Trifluoromethyl pyridinyloxyphenoxy and pyridinylthiophenoxy propanoic acids and propanols and derivatives thereof and methods of herbicidal use |
| US4279913A (en) * | 1978-01-04 | 1981-07-21 | Merck & Co., Inc. | Polysubstituted-2-(3-loweralkylamino-2-R1 O-propoxy)pyridines |
| JPS54106476A (en) * | 1978-01-04 | 1979-08-21 | Merck & Co Inc | Multiisubstituted 22*33lower alkylaminoo22 r100propoxy*pyridine |
| US4144343A (en) * | 1978-01-04 | 1979-03-13 | Merck & Co., Inc. | Heterocycle substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines |
| DK267779A (da) * | 1978-06-27 | 1979-12-28 | Merck & Co Inc | Fr&mgangsmaade til fremstilling af n-aralkylamino-propoxycyanopyridiner |
| US4208416A (en) * | 1978-06-27 | 1980-06-17 | Merck & Co., Inc. | N-Aralkyl containing cyanopyridines |
| US4210653A (en) * | 1978-06-27 | 1980-07-01 | Merck & Co., Inc. | Pyridyloxypropanolamines |
| US4393212A (en) * | 1979-01-29 | 1983-07-12 | Merck & Co., Inc. | Certain nicotinic acid esters and corresponding nicotinonitriles |
| US4294969A (en) * | 1979-01-29 | 1981-10-13 | Merck & Co., Inc. | Process for producing 2-bromo-3,5-disubstituted pyridines |
| DD150456A5 (de) * | 1979-03-01 | 1981-09-02 | Ciba Geigy Ag | Verfahren zur herstellung von derivaten des 3-amino-1,2-propandiols |
| US4281005A (en) | 1979-03-05 | 1981-07-28 | Merck & Co., Inc. | Novel 2-pyridylimidazole compounds |
| IT1165040B (it) * | 1979-04-23 | 1987-04-22 | Isf Spa | Alcossialchilidenidrazinopiridazione e procedimento per la loro preparazione |
| DE2943774A1 (de) * | 1979-10-26 | 1981-05-14 | 1000 Berlin Schering Ag Berlin Und Bergkamen | Substituierte pyridine, verfahren zu ihrer herstellung und ihre verwendung |
| IL62602A (en) * | 1980-05-19 | 1984-06-29 | Labaz Sanofi Nv | Pyridoxine derivatives,their preparation and pharmaceutical compositions containing them |
| FR2502618A1 (fr) * | 1981-03-25 | 1982-10-01 | Synthelabo | Derives de pyridine, leur preparation et leur application en therapeutique |
| US4517188A (en) * | 1983-05-09 | 1985-05-14 | Mead Johnson & Company | 1-Pyrimidinyloxy-3-hetaryl-alkylamino-2-propanols |
| US4598149A (en) * | 1984-03-02 | 1986-07-01 | Merck & Co., Inc. | 3-amino-2-hydroxypropyl of pyrimidin-4-one useful as antihypertensive, cardioprotective, antiarrythmic, and antianginal agents |
| US6465467B1 (en) | 1999-05-21 | 2002-10-15 | Biovitrum Ab | Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases |
| US7361671B2 (en) * | 2001-11-15 | 2008-04-22 | The Institute For Pharmaceutical Discovery, Inc. | Substituted heteroarylalkanoic acids |
| BR0311970A (pt) | 2002-06-19 | 2005-03-29 | Biovitrum Ab | Novos compostos, seu uso e preparação |
| CA2506741A1 (en) * | 2002-11-27 | 2004-06-17 | Artesian Therapeutics, Inc. | Compounds with mixed pde-inhibitory and .beta.-adrenergic antagonist or partial agonist activity for treatment of heart failure |
| EP1773776A1 (en) * | 2004-07-23 | 2007-04-18 | Bayer Cropscience Sa | 3-pyridinylethylbenzamide derivatives as fungicides |
| CA2774981A1 (en) * | 2009-09-21 | 2011-03-24 | Vanderbilt University | O-benzyl nicotinamide analogs as mglur5 positive allosteric modulators |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1001631A (en) * | 1972-05-05 | 1976-12-14 | Merck Sharp And Dohme (I.A.) Corp. | 2-(3-substituted amino-2-hydroxy-propoxy)-3-substituted pyrazines and method for preparation |
-
1974
- 1974-01-01 AR AR257058A patent/AR206801A1/es active
- 1974-01-01 AR AR257054A patent/AR208397A1/es active
- 1974-01-01 AR AR257055A patent/AR207133A1/es active
- 1974-01-29 SE SE7401114A patent/SE420834B/xx unknown
- 1974-02-11 IE IE255/74A patent/IE38839B1/xx unknown
- 1974-02-12 CA CA192,292A patent/CA1027131A/en not_active Expired
- 1974-02-13 IL IL44202A patent/IL44202A/xx unknown
- 1974-02-13 GB GB651874A patent/GB1465946A/en not_active Expired
- 1974-02-14 DE DE19742406930 patent/DE2406930A1/de not_active Ceased
- 1974-02-15 DK DK80774A patent/DK143501C/da not_active IP Right Cessation
- 1974-02-18 FR FR7405391A patent/FR2218101B1/fr not_active Expired
- 1974-02-18 DD DD176616A patent/DD110041A5/xx unknown
- 1974-02-18 LU LU69415A patent/LU69415A1/xx unknown
- 1974-02-19 BE BE141130A patent/BE811274A/xx not_active IP Right Cessation
- 1974-02-19 AT AT133074A patent/AT335455B/de not_active IP Right Cessation
- 1974-02-20 CS CS741252A patent/CS203970B2/cs unknown
- 1974-02-20 AR AR252438A patent/AR214612A1/es active
- 1974-12-23 AR AR257057A patent/AR203878A1/es active
-
1976
- 1976-01-01 AR AR264155A patent/AR208043A1/es active
- 1976-03-16 ES ES446083A patent/ES446083A1/es not_active Expired
- 1976-03-16 ES ES76446081A patent/ES446081A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CS203970B2 (en) | 1981-03-31 |
| AT335455B (de) | 1977-03-10 |
| IL44202A0 (en) | 1974-06-30 |
| CA1027131A (en) | 1978-02-28 |
| AR207133A1 (es) | 1976-09-15 |
| DD110041A5 (enExample) | 1974-12-05 |
| AR214612A1 (es) | 1979-07-13 |
| BE811274A (fr) | 1974-08-19 |
| DK143501B (da) | 1981-08-31 |
| AR203878A1 (es) | 1975-10-31 |
| ES446081A1 (es) | 1977-06-16 |
| AR208397A1 (es) | 1976-12-27 |
| DK143501C (da) | 1982-02-22 |
| IL44202A (en) | 1978-10-31 |
| FR2218101A1 (enExample) | 1974-09-13 |
| GB1465946A (en) | 1977-03-02 |
| DE2406930A1 (de) | 1974-08-22 |
| LU69415A1 (enExample) | 1975-12-09 |
| IE38839L (en) | 1974-08-20 |
| IE38839B1 (en) | 1978-06-07 |
| FR2218101B1 (enExample) | 1977-07-15 |
| AR208043A1 (es) | 1976-11-22 |
| SE420834B (sv) | 1981-11-02 |
| ATA133074A (de) | 1976-07-15 |
| AR206801A1 (es) | 1976-08-23 |
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