ES439291A1 - Procedimiento de preparacion de la n-trimetoxi-3, 4, 5-cina-moil)-n'-(pirrolidinona-2'-carbonilmetil-1')-piperazina. - Google Patents
Procedimiento de preparacion de la n-trimetoxi-3, 4, 5-cina-moil)-n'-(pirrolidinona-2'-carbonilmetil-1')-piperazina.Info
- Publication number
- ES439291A1 ES439291A1 ES439291A ES439291A ES439291A1 ES 439291 A1 ES439291 A1 ES 439291A1 ES 439291 A ES439291 A ES 439291A ES 439291 A ES439291 A ES 439291A ES 439291 A1 ES439291 A1 ES 439291A1
- Authority
- ES
- Spain
- Prior art keywords
- piperazine
- acid addition
- addition salts
- preparation
- therapeutic application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZQXXBLADSLNAAT-UHFFFAOYSA-N 1-piperazin-1-yl-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one Chemical class COC1=C(OC)C(OC)=CC(C=CC(=O)N2CCNCC2)=C1 ZQXXBLADSLNAAT-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- VXIVSQZSERGHQP-UHFFFAOYSA-N chloroacetamide Chemical compound NC(=O)CCl VXIVSQZSERGHQP-UHFFFAOYSA-N 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7424831A FR2278340A1 (fr) | 1974-07-17 | 1974-07-17 | Nouveau derive de la n-(trimethoxy-3,4,5 cinnamoyl) piperazine, ses sels d'addition d'acides, son procede de preparation et son application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES439291A1 true ES439291A1 (es) | 1977-02-16 |
Family
ID=9141387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES439291A Expired ES439291A1 (es) | 1974-07-17 | 1975-07-10 | Procedimiento de preparacion de la n-trimetoxi-3, 4, 5-cina-moil)-n'-(pirrolidinona-2'-carbonilmetil-1')-piperazina. |
Country Status (15)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2387971A1 (fr) * | 1977-04-19 | 1978-11-17 | Delalande Sa | Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique |
| FR2460942A1 (fr) * | 1979-07-12 | 1981-01-30 | Delalande Sa | Nouveaux derives de l'acide a-amino butyrique, leur procede de preparation et leur application en therapeutique |
| GR71991B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1980-01-21 | 1983-08-26 | Delalande Sa | |
| JPS5888370A (ja) * | 1981-11-19 | 1983-05-26 | Hokuriku Seiyaku Co Ltd | １−（３，４，５−トリメトキシシンナモイル）−４−アミノカルボニルエチル置換ピペラジン及びホモピペラジン誘導体、及びその製造方法 |
| ES510759A0 (es) * | 1982-03-24 | 1983-02-01 | Prodes Sa | "procedimiento para la obtencion de n-(2-oxo-1-pirrolidinil)acetil piperazinas sustituidas". |
| FR2552762B1 (fr) * | 1983-09-30 | 1986-07-25 | Delalande Sa | Nouveaux amides piperaziniques et homopiperaziniques derives de l'acide 3,4-dioxymethylene cinnamique, leur procede de preparation et leur application en therapeutique |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1218591A (en) * | 1968-04-03 | 1971-01-06 | Delalande Sa | Derivatives of n-(3,4,5-trimethoxy cennamoyl) piperazine and their process of preparation |
| BE754640A (fr) * | 1969-08-11 | 1971-02-10 | Geigy Ag J R | Derives de l'imidazolidinone et medicaments contenant de tels derives |
| BE754642A (fr) * | 1969-08-11 | 1971-02-10 | Geigy Ag J R | Derives de l'imidazolidinone et medicaments contenant de tels derives |
| GB1391007A (en) * | 1971-06-17 | 1975-04-16 | Ciba Geigy Ag | Imidazolidinone derivatives and processes for the production thereof |
| US3784545A (en) * | 1972-05-31 | 1974-01-08 | Abbott Lab | 1-(5-phenyl-4-oxo-2-oxazolin-2-yl)-4-cinnamoylpiperazines |
| US3806510A (en) * | 1972-09-18 | 1974-04-23 | Parke Davis & Co | 4(orthoalkylthio phenyl)piperazin-1-yl hydantoins |
-
1974
- 1974-07-17 FR FR7424831A patent/FR2278340A1/fr active Granted
-
1975
- 1975-06-30 GB GB2750275A patent/GB1452878A/en not_active Expired
- 1975-07-01 BE BE157877A patent/BE830874A/xx not_active IP Right Cessation
- 1975-07-03 ZA ZA00754268A patent/ZA754268B/xx unknown
- 1975-07-10 ES ES439291A patent/ES439291A1/es not_active Expired
- 1975-07-15 LU LU72983A patent/LU72983A1/xx unknown
- 1975-07-15 JP JP50086608A patent/JPS5134177A/ja active Granted
- 1975-07-15 US US05/596,041 patent/US4016154A/en not_active Expired - Lifetime
- 1975-07-16 SU SU7502152022A patent/SU569289A3/ru active
- 1975-07-16 IT IT68867/75A patent/IT1044530B/it active
- 1975-07-16 CH CH933175A patent/CH593966A5/xx not_active IP Right Cessation
- 1975-07-16 DE DE2531829A patent/DE2531829C2/de not_active Expired
- 1975-07-16 CA CA231,613A patent/CA1030538A/en not_active Expired
- 1975-07-16 NL NL7508530A patent/NL7508530A/xx not_active Application Discontinuation
- 1975-07-16 SE SE7508153A patent/SE417428B/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2278340B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1978-07-21 |
| NL7508530A (nl) | 1976-01-20 |
| SU569289A3 (ru) | 1977-08-15 |
| LU72983A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1976-05-31 |
| AU8308075A (en) | 1977-01-20 |
| SE7508153L (sv) | 1976-01-19 |
| US4016154A (en) | 1977-04-05 |
| IT1044530B (it) | 1980-03-31 |
| GB1452878A (en) | 1976-10-20 |
| JPS5134177A (en) | 1976-03-23 |
| DE2531829A1 (de) | 1976-02-05 |
| FR2278340A1 (fr) | 1976-02-13 |
| BE830874A (fr) | 1976-01-02 |
| DE2531829C2 (de) | 1985-12-12 |
| CH593966A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1977-12-30 |
| CA1030538A (en) | 1978-05-02 |
| JPS61337B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1986-01-08 |
| ZA754268B (en) | 1976-06-30 |
| SE417428B (sv) | 1981-03-16 |
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