ES433900A1 - Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES433900A1
ES433900A1 ES433900A ES433900A ES433900A1 ES 433900 A1 ES433900 A1 ES 433900A1 ES 433900 A ES433900 A ES 433900A ES 433900 A ES433900 A ES 433900A ES 433900 A1 ES433900 A1 ES 433900A1
Authority
ES
Spain
Prior art keywords
preparation
formula
bencilamines
translation
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES433900A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES433900A1 publication Critical patent/ES433900A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/24—Camphidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

The preparation of novel benzylamines of the formula I < IMAGE > in which the symbols R1 to R5 have the meanings stated in Claim 1, as well as their physiologically tolerated acid addition salts with inorganic or organic acids is described. The compounds of the formula I have valuable pharmacological properties, especially an antiulcer effect, a secretolytic, cough-suppressant effect and an effect enhancing the production of the surfactant or antiatelectasis factor in the alveoli. The compounds of the formula I are prepared by reducing the corresponding nitro compounds and, where appropriate, subsequently introducing the aliphatic or aromatic acyl radical R1 by N-acylation.
ES433900A 1974-02-05 1975-01-17 Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding) Expired ES433900A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19742405322 DE2405322A1 (en) 1974-02-05 1974-02-05 NEW METHODS FOR MANUFACTURING BENZYLAMINES

Publications (1)

Publication Number Publication Date
ES433900A1 true ES433900A1 (en) 1976-12-01

Family

ID=5906596

Family Applications (1)

Application Number Title Priority Date Filing Date
ES433900A Expired ES433900A1 (en) 1974-02-05 1975-01-17 Procedure for the preparation of new bencilamines. (Machine-translation by Google Translate, not legally binding)

Country Status (5)

Country Link
CH (7) CH609037A5 (en)
DE (1) DE2405322A1 (en)
ES (1) ES433900A1 (en)
PL (7) PL94234B1 (en)
SU (7) SU528866A3 (en)

Also Published As

Publication number Publication date
CH609035A5 (en) 1979-02-15
SU521838A3 (en) 1976-07-15
PL94232B1 (en) 1977-07-30
CH609329A5 (en) 1979-02-28
CH609037A5 (en) 1979-02-15
SU527134A3 (en) 1976-08-30
PL94231B1 (en) 1977-07-30
CH617662A5 (en) 1980-06-13
SU520035A3 (en) 1976-06-30
SU640657A3 (en) 1978-12-30
SU575021A3 (en) 1977-09-30
SU528866A3 (en) 1976-09-15
CH609036A5 (en) 1979-02-15
DE2405322A1 (en) 1975-09-04
PL96532B1 (en) 1977-12-31
PL95668B1 (en) 1977-11-30
PL96785B1 (en) 1978-01-31
CH592609A5 (en) 1977-10-31
CH609038A5 (en) 1979-02-15
SU523634A3 (en) 1976-07-30
PL94234B1 (en) 1977-07-30
PL94279B1 (en) 1977-07-30

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