CH609037A5 - Process for the preparation of novel benzylamines - Google Patents

Process for the preparation of novel benzylamines

Info

Publication number
CH609037A5
CH609037A5 CH529077A CH529077A CH609037A5 CH 609037 A5 CH609037 A5 CH 609037A5 CH 529077 A CH529077 A CH 529077A CH 529077 A CH529077 A CH 529077A CH 609037 A5 CH609037 A5 CH 609037A5
Authority
CH
Switzerland
Prior art keywords
formula
benzylamines
novel
preparation
effect
Prior art date
Application number
CH529077A
Inventor
Johannes Dr Keck
Klaus-Reinhold Dr Noll
Helmut Dr Pieper
Gerd Dr Krueger
Sigfrid Dr Pueschmann
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of CH609037A5 publication Critical patent/CH609037A5/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/24—Camphidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

The preparation of novel benzylamines of the formula I <IMAGE> in which the symbols R1 to R5 have the meanings stated in Claim 1, as well as their physiologically tolerated acid addition salts with inorganic or organic acids is described. The compounds of the formula I have valuable pharmacological properties, especially an antiulcer effect, a secretolytic, cough-suppressant effect and an effect enhancing the production of the surfactant or antiatelectasis factor in the alveoli. The compounds of the formula I are prepared by reacting an appropriately substituted benzaldehyde with a nitrogen compound which introduces the group -NR4R5, in the presence of formic acid.
CH529077A 1974-02-05 1974-04-09 Process for the preparation of novel benzylamines CH609037A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19742405322 DE2405322A1 (en) 1974-02-05 1974-02-05 NEW METHODS FOR MANUFACTURING BENZYLAMINES

Publications (1)

Publication Number Publication Date
CH609037A5 true CH609037A5 (en) 1979-02-15

Family

ID=5906596

Family Applications (7)

Application Number Title Priority Date Filing Date
CH529177A CH609038A5 (en) 1974-02-05 1974-04-09 Process for the preparation of novel benzylamines
CH529277A CH609329A5 (en) 1974-02-05 1974-04-09 Process for the preparation of novel benzylamines
CH528877A CH609035A5 (en) 1974-02-05 1974-04-09 Process for the preparation of novel benzylamines
CH529477A CH592609A5 (en) 1974-02-05 1974-04-09
CH529077A CH609037A5 (en) 1974-02-05 1974-04-09 Process for the preparation of novel benzylamines
CH528977A CH609036A5 (en) 1974-02-05 1974-04-09 Process for the preparation of novel benzylamines
CH529377A CH617662A5 (en) 1974-02-05 1977-04-28 Process for the preparation of novel benzylamines

Family Applications Before (4)

Application Number Title Priority Date Filing Date
CH529177A CH609038A5 (en) 1974-02-05 1974-04-09 Process for the preparation of novel benzylamines
CH529277A CH609329A5 (en) 1974-02-05 1974-04-09 Process for the preparation of novel benzylamines
CH528877A CH609035A5 (en) 1974-02-05 1974-04-09 Process for the preparation of novel benzylamines
CH529477A CH592609A5 (en) 1974-02-05 1974-04-09

Family Applications After (2)

Application Number Title Priority Date Filing Date
CH528977A CH609036A5 (en) 1974-02-05 1974-04-09 Process for the preparation of novel benzylamines
CH529377A CH617662A5 (en) 1974-02-05 1977-04-28 Process for the preparation of novel benzylamines

Country Status (5)

Country Link
CH (7) CH609038A5 (en)
DE (1) DE2405322A1 (en)
ES (1) ES433900A1 (en)
PL (7) PL96532B1 (en)
SU (7) SU521838A3 (en)

Also Published As

Publication number Publication date
DE2405322A1 (en) 1975-09-04
CH609038A5 (en) 1979-02-15
PL94232B1 (en) 1977-07-30
SU521838A3 (en) 1976-07-15
PL96785B1 (en) 1978-01-31
CH609329A5 (en) 1979-02-28
PL95668B1 (en) 1977-11-30
PL94234B1 (en) 1977-07-30
SU528866A3 (en) 1976-09-15
SU575021A3 (en) 1977-09-30
ES433900A1 (en) 1976-12-01
SU520035A3 (en) 1976-06-30
CH609036A5 (en) 1979-02-15
PL94279B1 (en) 1977-07-30
CH617662A5 (en) 1980-06-13
SU640657A3 (en) 1978-12-30
SU523634A3 (en) 1976-07-30
PL96532B1 (en) 1977-12-31
CH592609A5 (en) 1977-10-31
SU527134A3 (en) 1976-08-30
PL94231B1 (en) 1977-07-30
CH609035A5 (en) 1979-02-15

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Legal Events

Date Code Title Description
PL Patent ceased