ES3060733T3 - Kif18a inhibitors - Google Patents

Kif18a inhibitors

Info

Publication number
ES3060733T3
ES3060733T3 ES20754600T ES20754600T ES3060733T3 ES 3060733 T3 ES3060733 T3 ES 3060733T3 ES 20754600 T ES20754600 T ES 20754600T ES 20754600 T ES20754600 T ES 20754600T ES 3060733 T3 ES3060733 T3 ES 3060733T3
Authority
ES
Spain
Prior art keywords
kif18a
compounds
inhibitors
influencing
modulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES20754600T
Other languages
English (en)
Inventor
Nuria A Tamayo
Abhisek Banerjee
Matthew Paul Bourbeau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ES3060733T3 publication Critical patent/ES3060733T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos de fórmula (I): (I), según se definen en el presente documento, e intermedios sintéticos de los mismos, capaces de modular la proteína KIF18A, influyendo así en el ciclo celular y la proliferación celular para el tratamiento del cáncer y enfermedades relacionadas con este. La invención también incluye composiciones farmacéuticas, que contienen dichos compuestos, y métodos para el tratamiento de enfermedades relacionadas con la actividad de KIF18A. (Traducción automática con Google Translate, sin valor legal)
ES20754600T 2019-08-02 2020-08-03 Kif18a inhibitors Active ES3060733T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962882271P 2019-08-02 2019-08-02
PCT/US2020/044800 WO2021026101A1 (en) 2019-08-02 2020-08-03 Kif18a inhibitors

Publications (1)

Publication Number Publication Date
ES3060733T3 true ES3060733T3 (en) 2026-03-27

Family

ID=72047174

Family Applications (1)

Application Number Title Priority Date Filing Date
ES20754600T Active ES3060733T3 (en) 2019-08-02 2020-08-03 Kif18a inhibitors

Country Status (9)

Country Link
US (1) US20220281843A1 (es)
EP (1) EP4007756B1 (es)
JP (1) JP7640521B2 (es)
CN (1) CN114269731A (es)
AU (1) AU2020324963B2 (es)
CA (1) CA3147451A1 (es)
ES (1) ES3060733T3 (es)
MX (1) MX2022001181A (es)
WO (1) WO2021026101A1 (es)

Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
TWI844602B (zh) 2018-12-20 2024-06-11 美商安進公司 Kif18a抑制劑
JP2023521802A (ja) * 2020-04-14 2023-05-25 アムジエン・インコーポレーテツド 新生物疾患の処置のためのｋｉｆ１８ａ阻害剤
TW202237119A (zh) 2020-12-10 2022-10-01 美商住友製藥腫瘤公司 Ａｌｋ﹘５抑制劑和彼之用途
AU2022265064A1 (en) * 2021-04-30 2023-11-23 Chengdu Anticancer Bioscience, Ltd. Phenyl -o-quinoline, quinazoline, thienopyridine, thienopyrimidine, pyrrolopyridine, pyrrolopyrimidine compounds having anticancer activity
JP7773801B2 (ja) * 2021-06-25 2025-11-20 ハンジョウ イノゲート ファーマ カンパニー リミテッド Ｋｉｆ１８ａ阻害剤としての化合物
CN119241504A (zh) * 2021-08-26 2025-01-03 沃拉斯查疗法公司 Kif18a的螺吲哚啉抑制剂
KR20240156632A (ko) * 2022-04-15 2024-10-30 우한 휴먼웰 이노베이티브 드러그 리서치 앤드 디벨롭먼트 센터 리미티드 컴퍼니 Kif18a 억제제 및 이의 용도
CN119212988A (zh) * 2022-05-13 2024-12-27 上海湃隆生物科技有限公司 驱动蛋白kif18a抑制剂及其应用
CN116514777B (zh) * 2022-05-13 2024-07-19 上海湃隆生物科技有限公司 驱动蛋白kif18a抑制剂及其应用
KR20250027560A (ko) * 2022-06-30 2025-02-26 쑤저우 젠하우스 바이오 컴퍼니 리미티드 질소 함유 화합물 및 이의 용도
TW202416973A (zh) 2022-08-18 2024-05-01 美商雅客森醫療公司 Ｋｉｆ１８ａ抑制劑及其用途
CN119907796A (zh) * 2022-09-09 2025-04-29 海南先声再明医药股份有限公司 酰胺类化合物、其组合物及用途
TW202415648A (zh) * 2022-09-30 2024-04-16 大陸商長春金賽藥業有限責任公司 稠環類kif18a抑制劑化合物、藥物組合物及其製備方法和用途
WO2024078513A1 (en) * 2022-10-10 2024-04-18 Chengdu Anticancer Bioscience , Ltd. Condensed azines for treating cancer
WO2024083137A1 (zh) * 2022-10-19 2024-04-25 海南先声再明医药股份有限公司 稠合杂芳烃类化合物、其组合物及用途
CN115594664B (zh) * 2022-11-25 2023-02-24 英矽智能科技(上海)有限公司 一类螺环衍生物作为kif18a抑制剂
CN120265626A (zh) * 2022-12-14 2025-07-04 浙江海正药业股份有限公司 芳香酰胺类衍生物、其制备方法和其在医药上的应用
CN120752230A (zh) * 2022-12-28 2025-10-03 英矽智能科技知识产权有限公司 Kif18a的抑制剂及其用途
CN121002013A (zh) * 2023-04-18 2025-11-21 南京同诺康医药科技有限公司 Kif18a抑制剂及其制备方法和用途
CN121175315A (zh) * 2023-06-21 2025-12-19 正大天晴药业集团股份有限公司 三并环化合物及其医药用途
WO2025163351A1 (en) * 2024-02-02 2025-08-07 Satyarx Pharma Innovations Pvt Ltd Novel heterocyclic compounds as kif18a inhibitors

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