ES3041296T3 - Vectors for transforming mycoplasma hyopneumoniae, transformed m.hyopneumoniae strains, and use thereof - Google Patents

Vectors for transforming mycoplasma hyopneumoniae, transformed m.hyopneumoniae strains, and use thereof

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Publication number
ES3041296T3
ES3041296T3 ES19174710T ES19174710T ES3041296T3 ES 3041296 T3 ES3041296 T3 ES 3041296T3 ES 19174710 T ES19174710 T ES 19174710T ES 19174710 T ES19174710 T ES 19174710T ES 3041296 T3 ES3041296 T3 ES 3041296T3
Authority
ES
Spain
Prior art keywords
mhyo
dna sequence
protein
strain
pcv2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES19174710T
Other languages
English (en)
Spanish (es)
Inventor
Gonzalez Luis Gonzalez
Ribas Jaume Pinol
Giralt Jordi Montane
Malet Maria Camats
Murillo Enrique Querol
Arnau Marta Sitja
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hipra Scientific SL
Original Assignee
Hipra Scientific SL
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46832318&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES3041296(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hipra Scientific SL filed Critical Hipra Scientific SL
Application granted granted Critical
Publication of ES3041296T3 publication Critical patent/ES3041296T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/0241Mollicutes, e.g. Mycoplasma, Erysipelothrix
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/70Vectors containing special elements for cloning, e.g. topoisomerase, adaptor sites
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2820/00Vectors comprising a special origin of replication system
    • C12N2820/55Vectors comprising a special origin of replication system from bacteria
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/35Mycoplasma

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Pulmonology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
ES19174710T 2012-07-10 2013-07-09 Vectors for transforming mycoplasma hyopneumoniae, transformed m.hyopneumoniae strains, and use thereof Active ES3041296T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12382277.7A EP2684959A1 (en) 2012-07-10 2012-07-10 Vectors for transforming Mycoplasma hyopneumoniae, transformed M.hyopneumoniae strains, and use thereof

Publications (1)

Publication Number Publication Date
ES3041296T3 true ES3041296T3 (en) 2025-11-11

Family

ID=46832318

Family Applications (2)

Application Number Title Priority Date Filing Date
ES19174710T Active ES3041296T3 (en) 2012-07-10 2013-07-09 Vectors for transforming mycoplasma hyopneumoniae, transformed m.hyopneumoniae strains, and use thereof
ES13766387T Active ES2745720T5 (es) 2012-07-10 2013-07-09 Vectores para la transformación de Mycoplasma hyopneumoniae, cepas transformadas de M. hyopneumoniae, y uso de los mismos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES13766387T Active ES2745720T5 (es) 2012-07-10 2013-07-09 Vectores para la transformación de Mycoplasma hyopneumoniae, cepas transformadas de M. hyopneumoniae, y uso de los mismos

Country Status (13)

Country Link
US (1) US10076561B2 (enExample)
EP (3) EP2684959A1 (enExample)
JP (2) JP6571523B2 (enExample)
KR (1) KR102157911B1 (enExample)
BR (2) BR112015000585B1 (enExample)
DK (2) DK2873733T4 (enExample)
ES (2) ES3041296T3 (enExample)
MX (1) MX362977B (enExample)
PL (1) PL2873733T5 (enExample)
PT (1) PT2873733T (enExample)
RU (1) RU2689671C2 (enExample)
WO (1) WO2014009586A2 (enExample)
ZA (1) ZA201500067B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2684959A1 (en) * 2012-07-10 2014-01-15 Laboratorios Hipra, S.A. Vectors for transforming Mycoplasma hyopneumoniae, transformed M.hyopneumoniae strains, and use thereof
WO2014174257A2 (en) * 2013-04-22 2014-10-30 The Royal Veterinary College Methods
DK2994162T3 (en) 2013-05-08 2021-06-21 Pharmgate Biologics Inc Vaccine for pcv2 og mycoplasma
JP7510874B2 (ja) 2017-12-22 2024-07-04 ヒプラ シエンティフィック エセ.エレ.ウ. マイコプラズマ及びブタサーコウイルスに対する皮内混合ワクチン
CN110093324B (zh) * 2019-04-26 2020-02-18 中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心) 基因缺失的减毒非洲猪瘟病毒及其作为疫苗的应用
RU2743593C1 (ru) * 2020-12-09 2021-02-20 Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) Пептидные иммуногены и вакцинная композиция против коронавирусной инфекции COVID-19 с использованием пептидных иммуногенов
RU2743595C1 (ru) * 2020-12-09 2021-02-20 Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) Вакцинная композиция против коронавирусной инфекции COVID-19
RU2743594C1 (ru) * 2020-12-09 2021-02-20 Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) Пептидные иммуногены, используемые в качестве компонентов вакцинной композиции против коронавирусной инфекции COVID-19
RU2752858C1 (ru) * 2021-02-04 2021-08-11 Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) Интегративный плазмидный вектор pVEAL2-S-RBD, обеспечивающий экспрессию и секрецию рекомбинантного рецепторсвязывающего домена (RBD) коронавируса SARS-CoV-2 в клетках млекопитающих, рекомбинантный штамм клеточной линии CHO-K1-RBD и рекомбинантный белок RBD SARS-CoV-2, продуцируемый указанным штаммом клеточной линии CHO-K1-RBD
US20240415950A1 (en) * 2021-03-04 2024-12-19 Innovac Multivalent vaccine composition for prevention of porcine mycoplasma and porcine circovirus infections
KR102640730B1 (ko) * 2023-08-01 2024-02-29 주식회사 케어사이드 돼지 소모성 질병 관련 재조합 항원 제조용 신규한 벡터, 및 이를 이용한 백신 조성물
CN120366347A (zh) * 2025-03-17 2025-07-25 华南农业大学 一种质粒、副猪嗜血杆菌表面展示载体及其构建方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1707629B1 (en) * 2003-12-03 2011-06-08 Chugai Seiyaku Kabushiki Kaisha Expression system using mammalian beta-actin promoter
ME01000B (me) * 2007-11-06 2012-10-20 Zoetis Services Llc Živa vakcina avirulentne mycoplasma hyopneumoniae sa adjuvansom
KR20090061798A (ko) * 2007-12-12 2009-06-17 기아자동차주식회사 차량 시트용 시트 백의 허리 지지구조
TWI449533B (zh) * 2008-04-18 2014-08-21 Intervet Int Bv 防備胞內勞森菌(Lawsonia intracellularis)、豬肺炎黴漿菌(Mycoplasma hyopneumoniae)及豬環狀病毒(Porcine circo virus)用疫苗
JP2010136627A (ja) * 2008-12-09 2010-06-24 Nippon Oil Corp 酵母にガラクトースを利用させる方法
JP5257939B2 (ja) * 2009-02-24 2013-08-07 独立行政法人農業・食品産業技術総合研究機構 豚丹毒・豚マイコプラズマ肺炎経口投与型多価ワクチン
NZ596722A (en) * 2009-05-19 2013-08-30 Univ Melbourne A temperature sensitive vaccine strain of mycoplasma hyopneumoniae and uses thereof
US9260691B2 (en) * 2010-05-19 2016-02-16 Bioproperties Pty Ltd Methods relating to an attenuated mycoplasma
EP2684959A1 (en) * 2012-07-10 2014-01-15 Laboratorios Hipra, S.A. Vectors for transforming Mycoplasma hyopneumoniae, transformed M.hyopneumoniae strains, and use thereof
WO2014174257A2 (en) 2013-04-22 2014-10-30 The Royal Veterinary College Methods

Also Published As

Publication number Publication date
BR112015000585A2 (pt) 2017-08-08
ES2745720T3 (es) 2020-03-03
JP2019176861A (ja) 2019-10-17
EP2873733B1 (en) 2019-06-26
MX2015000287A (es) 2015-04-10
WO2014009586A3 (es) 2014-06-12
JP6571523B2 (ja) 2019-09-04
WO2014009586A8 (es) 2019-02-21
BR112015000585A8 (pt) 2018-01-16
BR112015000585B1 (pt) 2022-03-29
DK3546580T3 (da) 2025-12-01
DK2873733T4 (da) 2023-04-03
ZA201500067B (en) 2016-11-30
RU2689671C2 (ru) 2019-05-28
BR122022000531B1 (pt) 2022-06-21
PL2873733T5 (pl) 2023-05-15
RU2015104165A (ru) 2016-08-27
EP3546580B1 (en) 2025-09-03
KR20150027836A (ko) 2015-03-12
KR102157911B1 (ko) 2020-09-21
DK2873733T3 (da) 2019-09-30
MX362977B (es) 2019-02-28
EP3546580A1 (en) 2019-10-02
EP2873733A2 (en) 2015-05-20
EP2873733B2 (en) 2023-01-18
PL2873733T3 (pl) 2019-12-31
JP6883607B2 (ja) 2021-06-09
WO2014009586A2 (es) 2014-01-16
US10076561B2 (en) 2018-09-18
US20150306200A1 (en) 2015-10-29
ES2745720T5 (es) 2023-06-05
EP2684959A1 (en) 2014-01-15
JP2015523080A (ja) 2015-08-13
PT2873733T (pt) 2019-10-14

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