DK2873733T4 - Vektorer til transformation af mycoplasma hyopneumoniae, transformede m. hyopneumoniae-stammer og anvendelse deraf - Google Patents
Vektorer til transformation af mycoplasma hyopneumoniae, transformede m. hyopneumoniae-stammer og anvendelse deraf Download PDFInfo
- Publication number
- DK2873733T4 DK2873733T4 DK13766387.8T DK13766387T DK2873733T4 DK 2873733 T4 DK2873733 T4 DK 2873733T4 DK 13766387 T DK13766387 T DK 13766387T DK 2873733 T4 DK2873733 T4 DK 2873733T4
- Authority
- DK
- Denmark
- Prior art keywords
- hyopneumoniae
- vectors
- transformed
- transformation
- strains
- Prior art date
Links
- 241000204045 Mycoplasma hyopneumoniae Species 0.000 title 2
- 230000009466 transformation Effects 0.000 title 1
- 239000013598 vector Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0241—Mollicutes, e.g. Mycoplasma, Erysipelothrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/70—Vectors containing special elements for cloning, e.g. topoisomerase, adaptor sites
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2820/00—Vectors comprising a special origin of replication system
- C12N2820/55—Vectors comprising a special origin of replication system from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/35—Mycoplasma
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Pulmonology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12382277.7A EP2684959A1 (en) | 2012-07-10 | 2012-07-10 | Vectors for transforming Mycoplasma hyopneumoniae, transformed M.hyopneumoniae strains, and use thereof |
PCT/ES2013/070492 WO2014009586A2 (es) | 2012-07-10 | 2013-07-09 | Cepas mutantes de mycoplasma hyopneumoniae |
Publications (2)
Publication Number | Publication Date |
---|---|
DK2873733T3 DK2873733T3 (da) | 2019-09-30 |
DK2873733T4 true DK2873733T4 (da) | 2023-04-03 |
Family
ID=46832318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK13766387.8T DK2873733T4 (da) | 2012-07-10 | 2013-07-09 | Vektorer til transformation af mycoplasma hyopneumoniae, transformede m. hyopneumoniae-stammer og anvendelse deraf |
Country Status (13)
Country | Link |
---|---|
US (1) | US10076561B2 (da) |
EP (3) | EP2684959A1 (da) |
JP (2) | JP6571523B2 (da) |
KR (1) | KR102157911B1 (da) |
BR (2) | BR112015000585B1 (da) |
DK (1) | DK2873733T4 (da) |
ES (1) | ES2745720T5 (da) |
MX (1) | MX362977B (da) |
PL (1) | PL2873733T5 (da) |
PT (1) | PT2873733T (da) |
RU (1) | RU2689671C2 (da) |
WO (1) | WO2014009586A2 (da) |
ZA (1) | ZA201500067B (da) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2684959A1 (en) * | 2012-07-10 | 2014-01-15 | Laboratorios Hipra, S.A. | Vectors for transforming Mycoplasma hyopneumoniae, transformed M.hyopneumoniae strains, and use thereof |
WO2014174257A2 (en) * | 2013-04-22 | 2014-10-30 | The Royal Veterinary College | Methods |
WO2014182872A1 (en) | 2013-05-08 | 2014-11-13 | Protatek International, Inc. | Vaccine for pcv2 and mycoplasma |
BR112020012483A2 (pt) | 2017-12-22 | 2020-11-24 | Hipra Scientific, S.L.U. | vacina de combinação intradérmica contra mycoplasma e circovírus porcino |
CN110093324B (zh) * | 2019-04-26 | 2020-02-18 | 中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心) | 基因缺失的减毒非洲猪瘟病毒及其作为疫苗的应用 |
RU2743595C1 (ru) * | 2020-12-09 | 2021-02-20 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Вакцинная композиция против коронавирусной инфекции COVID-19 |
RU2743593C1 (ru) * | 2020-12-09 | 2021-02-20 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Пептидные иммуногены и вакцинная композиция против коронавирусной инфекции COVID-19 с использованием пептидных иммуногенов |
RU2743594C1 (ru) * | 2020-12-09 | 2021-02-20 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Пептидные иммуногены, используемые в качестве компонентов вакцинной композиции против коронавирусной инфекции COVID-19 |
RU2752858C1 (ru) * | 2021-02-04 | 2021-08-11 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Интегративный плазмидный вектор pVEAL2-S-RBD, обеспечивающий экспрессию и секрецию рекомбинантного рецепторсвязывающего домена (RBD) коронавируса SARS-CoV-2 в клетках млекопитающих, рекомбинантный штамм клеточной линии CHO-K1-RBD и рекомбинантный белок RBD SARS-CoV-2, продуцируемый указанным штаммом клеточной линии CHO-K1-RBD |
KR102640730B1 (ko) * | 2023-08-01 | 2024-02-29 | 주식회사 케어사이드 | 돼지 소모성 질병 관련 재조합 항원 제조용 신규한 벡터, 및 이를 이용한 백신 조성물 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8298816B2 (en) * | 2003-12-03 | 2012-10-30 | Chugai Seiyaku Kabushiki Kaisha | Expression systems using mammalian beta-actin promoter |
JP5869221B2 (ja) * | 2007-11-06 | 2016-02-24 | ゾエティス・ダブリュー・エルエルシー | アジュバント添加マイコプラズマ・ハイオニューモニエ非病原性生ワクチン |
KR20090061798A (ko) * | 2007-12-12 | 2009-06-17 | 기아자동차주식회사 | 차량 시트용 시트 백의 허리 지지구조 |
TWI449533B (zh) * | 2008-04-18 | 2014-08-21 | Intervet Int Bv | 防備胞內勞森菌(Lawsonia intracellularis)、豬肺炎黴漿菌(Mycoplasma hyopneumoniae)及豬環狀病毒(Porcine circo virus)用疫苗 |
JP2010136627A (ja) * | 2008-12-09 | 2010-06-24 | Nippon Oil Corp | 酵母にガラクトースを利用させる方法 |
JP5257939B2 (ja) * | 2009-02-24 | 2013-08-07 | 独立行政法人農業・食品産業技術総合研究機構 | 豚丹毒・豚マイコプラズマ肺炎経口投与型多価ワクチン |
PE20120909A1 (es) * | 2009-05-19 | 2012-08-19 | Bioproperties Pty Ltd | Cepa de vacuna de mycoplasma hyopneumoniae sensible a la temperatura y usos de la misma |
EA201291175A1 (ru) * | 2010-05-19 | 2013-06-28 | Байопропертис Пти Лтд. | Способы, относящиеся к аттенуированной микоплазме |
EP2684959A1 (en) * | 2012-07-10 | 2014-01-15 | Laboratorios Hipra, S.A. | Vectors for transforming Mycoplasma hyopneumoniae, transformed M.hyopneumoniae strains, and use thereof |
WO2014174257A2 (en) | 2013-04-22 | 2014-10-30 | The Royal Veterinary College | Methods |
-
2012
- 2012-07-10 EP EP12382277.7A patent/EP2684959A1/en not_active Withdrawn
-
2013
- 2013-07-09 MX MX2015000287A patent/MX362977B/es active IP Right Grant
- 2013-07-09 WO PCT/ES2013/070492 patent/WO2014009586A2/es active Application Filing
- 2013-07-09 ES ES13766387T patent/ES2745720T5/es active Active
- 2013-07-09 PL PL13766387.8T patent/PL2873733T5/pl unknown
- 2013-07-09 PT PT137663878T patent/PT2873733T/pt unknown
- 2013-07-09 EP EP13766387.8A patent/EP2873733B2/en active Active
- 2013-07-09 US US14/413,946 patent/US10076561B2/en active Active
- 2013-07-09 RU RU2015104165A patent/RU2689671C2/ru active
- 2013-07-09 BR BR112015000585-3A patent/BR112015000585B1/pt active IP Right Grant
- 2013-07-09 EP EP19174710.4A patent/EP3546580A1/en active Pending
- 2013-07-09 JP JP2015521032A patent/JP6571523B2/ja active Active
- 2013-07-09 DK DK13766387.8T patent/DK2873733T4/da active
- 2013-07-09 BR BR122022000531-4A patent/BR122022000531B1/pt active IP Right Grant
- 2013-07-09 KR KR1020157003569A patent/KR102157911B1/ko active IP Right Grant
-
2015
- 2015-01-06 ZA ZA2015/00067A patent/ZA201500067B/en unknown
-
2019
- 2019-05-22 JP JP2019095908A patent/JP6883607B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
US20150306200A1 (en) | 2015-10-29 |
PL2873733T3 (pl) | 2019-12-31 |
EP2873733B1 (en) | 2019-06-26 |
WO2014009586A8 (es) | 2019-02-21 |
BR112015000585A8 (pt) | 2018-01-16 |
JP6571523B2 (ja) | 2019-09-04 |
ES2745720T3 (es) | 2020-03-03 |
BR122022000531B1 (pt) | 2022-06-21 |
BR112015000585B1 (pt) | 2022-03-29 |
KR20150027836A (ko) | 2015-03-12 |
BR112015000585A2 (pt) | 2017-08-08 |
EP3546580A1 (en) | 2019-10-02 |
JP2019176861A (ja) | 2019-10-17 |
WO2014009586A2 (es) | 2014-01-16 |
EP2873733B2 (en) | 2023-01-18 |
EP2873733A2 (en) | 2015-05-20 |
MX2015000287A (es) | 2015-04-10 |
KR102157911B1 (ko) | 2020-09-21 |
US10076561B2 (en) | 2018-09-18 |
EP2684959A1 (en) | 2014-01-15 |
RU2015104165A (ru) | 2016-08-27 |
JP6883607B2 (ja) | 2021-06-09 |
ZA201500067B (en) | 2016-11-30 |
WO2014009586A3 (es) | 2014-06-12 |
DK2873733T3 (da) | 2019-09-30 |
ES2745720T5 (es) | 2023-06-05 |
PT2873733T (pt) | 2019-10-14 |
MX362977B (es) | 2019-02-28 |
PL2873733T5 (pl) | 2023-05-15 |
JP2015523080A (ja) | 2015-08-13 |
RU2689671C2 (ru) | 2019-05-28 |
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