BR112015000585B1 - Métodos para preparar uma cepa mutante de mycoplasma hyopneumoniae, vetores, cepa mutante de mhyo e seu uso, vacina e kit de vacinação - Google Patents

Métodos para preparar uma cepa mutante de mycoplasma hyopneumoniae, vetores, cepa mutante de mhyo e seu uso, vacina e kit de vacinação Download PDF

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Publication number
BR112015000585B1
BR112015000585B1 BR112015000585-3A BR112015000585A BR112015000585B1 BR 112015000585 B1 BR112015000585 B1 BR 112015000585B1 BR 112015000585 A BR112015000585 A BR 112015000585A BR 112015000585 B1 BR112015000585 B1 BR 112015000585B1
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Prior art keywords
mhyo
dna sequence
protein
gene
virus
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BR112015000585-3A
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English (en)
Portuguese (pt)
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BR112015000585A2 (pt
BR112015000585A8 (pt
Inventor
Luis GONZALEZ GONZALEZ
Jaume PINOL RIBAS
Jordi MONTANE GIRALT
Maria CAMATS MALET
Enrique Querol Murillo
Marta SITJA ARNAU
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Hipra Scientific, S.L.U.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46832318&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015000585(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hipra Scientific, S.L.U. filed Critical Hipra Scientific, S.L.U.
Priority to BR122022000531-4A priority Critical patent/BR122022000531B1/pt
Publication of BR112015000585A2 publication Critical patent/BR112015000585A2/pt
Publication of BR112015000585A8 publication Critical patent/BR112015000585A8/pt
Publication of BR112015000585B1 publication Critical patent/BR112015000585B1/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/0241Mollicutes, e.g. Mycoplasma, Erysipelothrix
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
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    • AHUMAN NECESSITIES
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    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
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    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/35Mycoplasma

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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BR112015000585-3A 2012-07-10 2013-07-09 Métodos para preparar uma cepa mutante de mycoplasma hyopneumoniae, vetores, cepa mutante de mhyo e seu uso, vacina e kit de vacinação BR112015000585B1 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122022000531-4A BR122022000531B1 (pt) 2012-07-10 2013-07-09 Cepa mutante de mhyo, vacina e kit de vacinação

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12382277.7A EP2684959A1 (en) 2012-07-10 2012-07-10 Vectors for transforming Mycoplasma hyopneumoniae, transformed M.hyopneumoniae strains, and use thereof
EP12382277.7 2012-07-10
PCT/ES2013/070492 WO2014009586A2 (es) 2012-07-10 2013-07-09 Cepas mutantes de mycoplasma hyopneumoniae

Publications (3)

Publication Number Publication Date
BR112015000585A2 BR112015000585A2 (pt) 2017-08-08
BR112015000585A8 BR112015000585A8 (pt) 2018-01-16
BR112015000585B1 true BR112015000585B1 (pt) 2022-03-29

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BR122022000531-4A BR122022000531B1 (pt) 2012-07-10 2013-07-09 Cepa mutante de mhyo, vacina e kit de vacinação
BR112015000585-3A BR112015000585B1 (pt) 2012-07-10 2013-07-09 Métodos para preparar uma cepa mutante de mycoplasma hyopneumoniae, vetores, cepa mutante de mhyo e seu uso, vacina e kit de vacinação

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BR122022000531-4A BR122022000531B1 (pt) 2012-07-10 2013-07-09 Cepa mutante de mhyo, vacina e kit de vacinação

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US (1) US10076561B2 (enExample)
EP (3) EP2684959A1 (enExample)
JP (2) JP6571523B2 (enExample)
KR (1) KR102157911B1 (enExample)
BR (2) BR122022000531B1 (enExample)
DK (2) DK2873733T4 (enExample)
ES (2) ES2745720T5 (enExample)
MX (1) MX362977B (enExample)
PL (1) PL2873733T5 (enExample)
PT (1) PT2873733T (enExample)
RU (1) RU2689671C2 (enExample)
WO (1) WO2014009586A2 (enExample)
ZA (1) ZA201500067B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2684959A1 (en) * 2012-07-10 2014-01-15 Laboratorios Hipra, S.A. Vectors for transforming Mycoplasma hyopneumoniae, transformed M.hyopneumoniae strains, and use thereof
WO2014174257A2 (en) * 2013-04-22 2014-10-30 The Royal Veterinary College Methods
EP2994162B1 (en) 2013-05-08 2021-04-07 Pharmgate Biologics Inc. Vaccine for pcv2 and mycoplasma
JP7510874B2 (ja) 2017-12-22 2024-07-04 ヒプラ シエンティフィック エセ.エレ.ウ. マイコプラズマ及びブタサーコウイルスに対する皮内混合ワクチン
CN110093324B (zh) * 2019-04-26 2020-02-18 中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心) 基因缺失的减毒非洲猪瘟病毒及其作为疫苗的应用
RU2743595C1 (ru) * 2020-12-09 2021-02-20 Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) Вакцинная композиция против коронавирусной инфекции COVID-19
RU2743593C1 (ru) * 2020-12-09 2021-02-20 Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) Пептидные иммуногены и вакцинная композиция против коронавирусной инфекции COVID-19 с использованием пептидных иммуногенов
RU2743594C1 (ru) * 2020-12-09 2021-02-20 Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) Пептидные иммуногены, используемые в качестве компонентов вакцинной композиции против коронавирусной инфекции COVID-19
RU2752858C1 (ru) * 2021-02-04 2021-08-11 Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) Интегративный плазмидный вектор pVEAL2-S-RBD, обеспечивающий экспрессию и секрецию рекомбинантного рецепторсвязывающего домена (RBD) коронавируса SARS-CoV-2 в клетках млекопитающих, рекомбинантный штамм клеточной линии CHO-K1-RBD и рекомбинантный белок RBD SARS-CoV-2, продуцируемый указанным штаммом клеточной линии CHO-K1-RBD
WO2022186661A1 (ko) * 2021-03-04 2022-09-09 주식회사 이노백 돼지 마이코플라스마균 및 돼지 써코바이러스 감염 예방을 위한 다가 백신 조성물
KR102640730B1 (ko) * 2023-08-01 2024-02-29 주식회사 케어사이드 돼지 소모성 질병 관련 재조합 항원 제조용 신규한 벡터, 및 이를 이용한 백신 조성물
CN120366347A (zh) * 2025-03-17 2025-07-25 华南农业大学 一种质粒、副猪嗜血杆菌表面展示载体及其构建方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004295590B2 (en) * 2003-12-03 2010-04-29 Chugai Seiyaku Kabushiki Kaisha Expression systems using mammalian beta-actin promoter
AU2008324780A1 (en) * 2007-11-06 2009-05-14 Pah W Llc Mycoplasma hyopneumoniae avirulent -adjuvanted live vaccine
KR20090061798A (ko) * 2007-12-12 2009-06-17 기아자동차주식회사 차량 시트용 시트 백의 허리 지지구조
TWI449533B (zh) * 2008-04-18 2014-08-21 Intervet Int Bv 防備胞內勞森菌(Lawsonia intracellularis)、豬肺炎黴漿菌(Mycoplasma hyopneumoniae)及豬環狀病毒(Porcine circo virus)用疫苗
JP2010136627A (ja) * 2008-12-09 2010-06-24 Nippon Oil Corp 酵母にガラクトースを利用させる方法
JP5257939B2 (ja) * 2009-02-24 2013-08-07 独立行政法人農業・食品産業技術総合研究機構 豚丹毒・豚マイコプラズマ肺炎経口投与型多価ワクチン
PE20120909A1 (es) * 2009-05-19 2012-08-19 Bioproperties Pty Ltd Cepa de vacuna de mycoplasma hyopneumoniae sensible a la temperatura y usos de la misma
CN102985530A (zh) * 2010-05-19 2013-03-20 澳大利亚生物资源公司 涉及减毒支原体的方法
EP2684959A1 (en) * 2012-07-10 2014-01-15 Laboratorios Hipra, S.A. Vectors for transforming Mycoplasma hyopneumoniae, transformed M.hyopneumoniae strains, and use thereof
WO2014174257A2 (en) 2013-04-22 2014-10-30 The Royal Veterinary College Methods

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ES3041296T3 (en) 2025-11-11
RU2689671C2 (ru) 2019-05-28
ES2745720T3 (es) 2020-03-03
EP2873733B1 (en) 2019-06-26
JP6883607B2 (ja) 2021-06-09
US10076561B2 (en) 2018-09-18
JP6571523B2 (ja) 2019-09-04
BR122022000531B1 (pt) 2022-06-21
US20150306200A1 (en) 2015-10-29
WO2014009586A2 (es) 2014-01-16
ZA201500067B (en) 2016-11-30
MX2015000287A (es) 2015-04-10
EP2873733A2 (en) 2015-05-20
JP2019176861A (ja) 2019-10-17
BR112015000585A2 (pt) 2017-08-08
RU2015104165A (ru) 2016-08-27
BR112015000585A8 (pt) 2018-01-16
PT2873733T (pt) 2019-10-14
MX362977B (es) 2019-02-28
EP3546580B1 (en) 2025-09-03
ES2745720T5 (es) 2023-06-05
JP2015523080A (ja) 2015-08-13
PL2873733T3 (pl) 2019-12-31
WO2014009586A3 (es) 2014-06-12
KR102157911B1 (ko) 2020-09-21
DK2873733T4 (da) 2023-04-03
WO2014009586A8 (es) 2019-02-21
PL2873733T5 (pl) 2023-05-15
KR20150027836A (ko) 2015-03-12
EP3546580A1 (en) 2019-10-02
EP2684959A1 (en) 2014-01-15
EP2873733B2 (en) 2023-01-18
DK2873733T3 (da) 2019-09-30
DK3546580T3 (da) 2025-12-01

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