ES3010649T3 - Gluten-related disorders - Google Patents

Gluten-related disorders Download PDF

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Publication number
ES3010649T3
ES3010649T3 ES21165677T ES21165677T ES3010649T3 ES 3010649 T3 ES3010649 T3 ES 3010649T3 ES 21165677 T ES21165677 T ES 21165677T ES 21165677 T ES21165677 T ES 21165677T ES 3010649 T3 ES3010649 T3 ES 3010649T3
Authority
ES
Spain
Prior art keywords
gluten
composition
cells
cba
paracasei
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES21165677T
Other languages
English (en)
Spanish (es)
Inventor
Francesca Romana Fasano
Andrea Luigi Budelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HJ Heinz Co Brands LLC
Original Assignee
HJ Heinz Co Brands LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HJ Heinz Co Brands LLC filed Critical HJ Heinz Co Brands LLC
Application granted granted Critical
Publication of ES3010649T3 publication Critical patent/ES3010649T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/335—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Lactobacillus (G)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES21165677T 2012-06-18 2013-06-18 Gluten-related disorders Active ES3010649T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261661105P 2012-06-18 2012-06-18
US201261725693P 2012-11-13 2012-11-13

Publications (1)

Publication Number Publication Date
ES3010649T3 true ES3010649T3 (en) 2025-04-04

Family

ID=49769279

Family Applications (3)

Application Number Title Priority Date Filing Date
ES21165677T Active ES3010649T3 (en) 2012-06-18 2013-06-18 Gluten-related disorders
ES13807318.4T Active ES2691087T3 (es) 2012-06-18 2013-06-18 Trastornos relacionados con el gluten
ES18157990T Active ES2883552T3 (es) 2012-06-18 2013-06-18 Trastornos relacionados con el gluten

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES13807318.4T Active ES2691087T3 (es) 2012-06-18 2013-06-18 Trastornos relacionados con el gluten
ES18157990T Active ES2883552T3 (es) 2012-06-18 2013-06-18 Trastornos relacionados con el gluten

Country Status (16)

Country Link
US (1) US10245300B2 (enExample)
EP (3) EP3901164B1 (enExample)
CN (1) CN104661671B (enExample)
AU (2) AU2013277316B2 (enExample)
BR (1) BR112014031666B1 (enExample)
CA (1) CA2876963C (enExample)
DK (3) DK3351554T3 (enExample)
ES (3) ES3010649T3 (enExample)
IN (1) IN2014DN10798A (enExample)
MX (1) MX363899B (enExample)
NZ (1) NZ702936A (enExample)
PL (3) PL3351554T3 (enExample)
PT (3) PT3901164T (enExample)
RU (1) RU2654705C2 (enExample)
TR (1) TR201814973T4 (enExample)
WO (1) WO2013192163A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2734049T (pt) 2011-06-20 2018-07-24 Heinz Co Brands H J Llc Composições e métodos probióticos
BR112015028164B1 (pt) 2013-05-10 2022-02-08 H.J. Heinz Company Brands Llc Usos da bactéria probiótica, lactobacillus paracasei, para tratar uma infecção microbiana e para prevenir ou reduzir a gravidade de uma infecção microbiana
MX2019008292A (es) * 2017-01-12 2019-09-16 Probi Ab Composiciones probioticas y usos de las mismas.
CN113143973A (zh) * 2017-03-07 2021-07-23 景岳生物科技股份有限公司 抗骨质流失的副干酪乳杆菌菌株gmnl-653的组合物
KR102244007B1 (ko) * 2019-02-14 2021-04-23 주식회사 메디뉴트롤 글루텐 분해능을 가지는 락토바실러스 파라카제이 glu70 균주를 유효성분으로 함유하는 글리아딘으로 야기된 염증성 장 질환의 예방, 개선 또는 치료용 조성물
PL447563A1 (pl) * 2024-01-22 2025-07-28 Nordic Biotic Spółka Z Ograniczoną Odpowiedzialnością Szczep Lacticaseibacillus (L.) casei LC130, szczep Lacticaseibacillus (L.) paracasei LPC100, szczep Streptococcus (S.) salivarius ssp. thermophilus ST250, kompozycja obniżająca immunoreaktywność peptydów gliadyny oraz zastosowanie szczepów do wytwarzania kompozycji

Family Cites Families (31)

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Publication number Priority date Publication date Assignee Title
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DE130228T1 (de) 1983-07-01 1985-09-12 Microlife Technics Inc., Sarasota, Fla. Fermentierungsverfahren mit einem selektierten lactobacillus.
RU2134583C1 (ru) 1996-02-29 1999-08-20 Санкт-Петербургская государственная педиатрическая медицинская академия Способ санации женщин с массивной микробной обсемененностью грудного молока
WO1997049303A1 (en) 1996-06-21 1997-12-31 Quest International B.V. Fermentation of fruit products
SE510813C2 (sv) 1997-12-08 1999-06-28 Arla Ekonomisk Foerening Bakteriestam av arten Lactobacillus Paracasei subsp. paracasei, sammansättning därav för användning i livsmedel, samt produkt innehållande stammen
EP1034787A1 (en) 1999-03-11 2000-09-13 Société des Produits Nestlé S.A. Lactobacillus strains preventing diarrhea caused by pathogenic bacteria
FI110668B (fi) 2000-06-20 2003-03-14 Aboatech Ab Oy Probioottien käyttö atooppisten sairauksien primaariseen ehkäisyyn
SE0003100D0 (sv) 2000-09-01 2000-09-01 Probi Ab New strains
KR100419132B1 (ko) 2000-12-29 2004-02-18 조성근 위·장 점막 부착성과 증식성, 내산성, 내담즙성 및헬리코박터 파일로리, 대장균 0157:h7에 대한 항균성이우수한 락토바실러스 파라카제이 서브스패시즈 파라카제이csk 01
AU2003215272B2 (en) * 2002-02-14 2008-04-03 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
EP1364586A1 (en) 2002-05-24 2003-11-26 Nestec S.A. Probiotics and oral tolerance
SI1565547T2 (sl) 2002-06-28 2013-02-28 Biosearch S.A. Probiotiäśni sevi, postopek za izbiranje le-teh, njihovi sestavki in njihova uporaba
US7955834B2 (en) 2004-06-03 2011-06-07 Biogaia Ab Method for improved breast milk feeding to reduce the risk of allergy
CN101365671B (zh) 2005-12-08 2012-07-04 麒麟控股株式会社 异葎草酮化合物包合物及含有该包合物的组合物
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CN101451158A (zh) * 2007-12-04 2009-06-10 黑龙江大学 副干酪乳杆菌产生的抗菌肽的分离纯化方法
EP2110027A1 (en) 2008-04-01 2009-10-21 Nestec S.A. Long-chain polyunsaturated fatty acids (LC-PUFA) in maternal nutrition during pregnancy and lactation
CN102065872A (zh) 2008-05-27 2011-05-18 雀巢产品技术援助有限公司 改善肠微生物群的益生菌
EP2138187A1 (en) 2008-06-24 2009-12-30 Nestec S.A. Probiotics, secretory IgA and infection
US20100196341A1 (en) 2009-02-05 2010-08-05 Syngen Biotech Co., Ltd. Novel Lactobacillus paracasei subsp. paracasei SG96, a Bacteriostatic Composition Containing the same and Use Thereof
EP2308498A1 (en) 2009-09-30 2011-04-13 Nestec S.A. Administration of Bifidobacterium breve during infancy to prevent inflammation later in life
EA031179B1 (ru) * 2010-03-12 2018-11-30 Компани Жервэ Данон Молочнокислые бактерии, применяемые при чревной болезни
CN102021127B (zh) * 2010-07-28 2012-05-30 江南大学 一株副干酪乳杆菌及其应用
EP2449891A1 (en) 2010-11-05 2012-05-09 Nestec S.A. Drinking yoghurt preparations containing non-replicating probiotic micro-organisms
EP2449890A1 (en) 2010-11-05 2012-05-09 Nestec S.A. Powdered cereal compositions comprising non-replicating probiotic microorganisms
EP2455094A1 (en) 2010-11-11 2012-05-23 Nestec S.A. Non-replicating probiotic micro-organisms protect children against gastrointestinal infections
EP2510932A1 (en) 2011-04-15 2012-10-17 Nestec S.A. Lactobacillus paracasei NCC2461 (ST11) for use by perinatal maternal administration in the reduction and prevention of allergies in progeny
PT2734049T (pt) * 2011-06-20 2018-07-24 Heinz Co Brands H J Llc Composições e métodos probióticos
KR20140088861A (ko) 2011-09-28 2014-07-11 필립스 66 컴퍼니 복합 고체 산화물 연료 전지 전해질
BR112015028164B1 (pt) 2013-05-10 2022-02-08 H.J. Heinz Company Brands Llc Usos da bactéria probiótica, lactobacillus paracasei, para tratar uma infecção microbiana e para prevenir ou reduzir a gravidade de uma infecção microbiana

Also Published As

Publication number Publication date
EP2861242A4 (en) 2016-01-20
CA2876963A1 (en) 2013-12-27
AU2013277316A1 (en) 2015-01-22
AU2013277316B2 (en) 2018-03-01
DK2861242T3 (en) 2018-10-29
WO2013192163A1 (en) 2013-12-27
CA2876963C (en) 2021-07-06
AU2018203543B2 (en) 2020-02-27
CN104661671A (zh) 2015-05-27
ES2883552T3 (es) 2021-12-09
US10245300B2 (en) 2019-04-02
IN2014DN10798A (enExample) 2015-09-04
US20150174199A1 (en) 2015-06-25
CN104661671B (zh) 2020-10-23
RU2014150934A (ru) 2016-08-10
PT3351554T (pt) 2021-08-06
PL3351554T3 (pl) 2021-11-15
DK3351554T3 (da) 2021-08-30
BR112014031666B1 (pt) 2022-10-04
AU2018203543A1 (en) 2018-06-07
EP2861242B1 (en) 2018-08-08
TR201814973T4 (tr) 2018-11-21
EP3901164B1 (en) 2024-11-20
BR112014031666A2 (pt) 2017-10-31
PL3901164T3 (pl) 2025-04-14
EP3901164A1 (en) 2021-10-27
MX2014015314A (es) 2015-10-29
PT3901164T (pt) 2025-02-13
EP3351554A1 (en) 2018-07-25
EP3351554B1 (en) 2021-06-09
NZ702936A (en) 2017-06-30
PL2861242T3 (pl) 2019-04-30
MX363899B (es) 2019-04-05
ES2691087T3 (es) 2018-11-23
DK3901164T3 (da) 2025-02-03
RU2654705C2 (ru) 2018-05-22
PT2861242T (pt) 2018-11-07
EP2861242A1 (en) 2015-04-22

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