ES2998534T3 - Phenyl carbamate compounds for use in preventing or treating pediatric epilesy - Google Patents

Phenyl carbamate compounds for use in preventing or treating pediatric epilesy Download PDF

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Publication number
ES2998534T3
ES2998534T3 ES14762362T ES14762362T ES2998534T3 ES 2998534 T3 ES2998534 T3 ES 2998534T3 ES 14762362 T ES14762362 T ES 14762362T ES 14762362 T ES14762362 T ES 14762362T ES 2998534 T3 ES2998534 T3 ES 2998534T3
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ES
Spain
Prior art keywords
chlorophenyl
hydroxypropyl
carbamate
preparation example
epilepsy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES14762362T
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English (en)
Spanish (es)
Inventor
Yong Moon Choi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Pharm Solutions Co Ltd
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Bio Pharm Solutions Co Ltd
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Filing date
Publication date
Application filed by Bio Pharm Solutions Co Ltd filed Critical Bio Pharm Solutions Co Ltd
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Publication of ES2998534T3 publication Critical patent/ES2998534T3/es
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A61K31/03—Halogenated hydrocarbons carbocyclic aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A61K31/055—Phenols the aromatic ring being substituted by halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES14762362T 2013-03-12 2014-03-07 Phenyl carbamate compounds for use in preventing or treating pediatric epilesy Active ES2998534T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361776926P 2013-03-12 2013-03-12
PCT/KR2014/001903 WO2014142477A1 (en) 2013-03-12 2014-03-07 Phenyl carbamate compounds for use in preventing or treating pediatric epilesy and epilesy-related syndromes

Publications (1)

Publication Number Publication Date
ES2998534T3 true ES2998534T3 (en) 2025-02-20

Family

ID=51530016

Family Applications (3)

Application Number Title Priority Date Filing Date
ES14762362T Active ES2998534T3 (en) 2013-03-12 2014-03-07 Phenyl carbamate compounds for use in preventing or treating pediatric epilesy
ES14764227T Active ES2881850T3 (es) 2013-03-12 2014-03-11 Compuestos de carmato de fenil alquilo para su uso en la prevención o tratamiento de la epilepsia o síndrome relacionado con la epilepsia
ES14764907T Active ES3046835T3 (en) 2013-03-12 2014-03-11 Phenyl carbamate compounds for use in preventing or treating epilepsy or epilepsy-related syndrome

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES14764227T Active ES2881850T3 (es) 2013-03-12 2014-03-11 Compuestos de carmato de fenil alquilo para su uso en la prevención o tratamiento de la epilepsia o síndrome relacionado con la epilepsia
ES14764907T Active ES3046835T3 (en) 2013-03-12 2014-03-11 Phenyl carbamate compounds for use in preventing or treating epilepsy or epilepsy-related syndrome

Country Status (7)

Country Link
US (5) US9504668B2 (https=)
EP (4) EP2968210B1 (https=)
JP (5) JP6062077B2 (https=)
KR (5) KR101717872B1 (https=)
CN (6) CN105228604A (https=)
ES (3) ES2998534T3 (https=)
WO (4) WO2014142477A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
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US9566261B2 (en) 2013-03-12 2017-02-14 Bio-Pharm Solutions Co., Ltd. Phenyl carbamate compound and a composition for preventing or treating a memory loss-related disease comprising the same
EP2968210B1 (en) * 2013-03-12 2024-09-11 Bio-Pharm Solutions Co., Ltd. Phenyl carbamate compounds for use in preventing or treating pediatric epilesy
ES3059582T3 (en) * 2016-02-29 2026-03-23 Bio Pharm Solutions Co Ltd Sulfamate derivative compounds, processes for preparing them and their uses
MX391363B (es) * 2016-12-14 2025-03-21 Sk Biopharmaceuticals Co Ltd Uso de compuesto de carbamato para prevenir, aliviar o tratar temblores o el sindrome de temblor.
CN109920550A (zh) * 2018-12-25 2019-06-21 天津大学 一种基于dMRI研究青少年肌阵挛性癫痫的方法
JP2023539291A (ja) * 2020-08-31 2023-09-13 バイオ－ファーム ソリューションズ カンパニー リミテッド 神経変性疾患の予防又は治療用フェニルアルキルカルバメート化合物
KR20230051206A (ko) 2020-09-10 2023-04-17 (주)바이오팜솔루션즈 정신질환 치료 또는 완화용 설파메이트 유도체 화합물
US12054449B2 (en) 2021-08-05 2024-08-06 Bio-Pharm Solutions Co., Ltd. Phenylcarbamate crystalline form and method for manufacturing the same
CN119552104B (zh) * 2024-12-03 2025-07-15 西安瑞谱源生物技术有限公司 一种氘代维生素a的制备方法

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Also Published As

Publication number Publication date
CN109939092A (zh) 2019-06-28
KR20150122211A (ko) 2015-10-30
KR101992035B1 (ko) 2019-06-21
CN105188690B (zh) 2020-06-12
JP2016510811A (ja) 2016-04-11
JP2016510812A (ja) 2016-04-11
EP2968212A1 (en) 2016-01-20
CN109939092B (zh) 2022-03-22
WO2014142519A1 (en) 2014-09-18
JP2016512232A (ja) 2016-04-25
CN105188689A (zh) 2015-12-23
KR20150120518A (ko) 2015-10-27
JP6215971B2 (ja) 2017-10-18
US20160030382A1 (en) 2016-02-04
WO2014142520A1 (en) 2014-09-18
US20160296493A1 (en) 2016-10-13
US9872847B2 (en) 2018-01-23
KR101739676B1 (ko) 2017-05-24
EP2968212B1 (en) 2025-09-10
EP2968210B1 (en) 2024-09-11
KR20150119955A (ko) 2015-10-26
JP6062077B2 (ja) 2017-01-18
EP2968211A1 (en) 2016-01-20
CN105188690A (zh) 2015-12-23
EP2968211B1 (en) 2021-05-12
US20140275243A1 (en) 2014-09-18
KR101717873B1 (ko) 2017-03-17
KR101717872B1 (ko) 2017-03-17
CN105188689B (zh) 2020-04-10
JP6062078B2 (ja) 2017-01-18
EP2968210A4 (en) 2016-12-28
KR20150120520A (ko) 2015-10-27
US9504668B2 (en) 2016-11-29
EP2968213A4 (en) 2016-12-21
CN105209027A (zh) 2015-12-30
ES2881850T3 (es) 2021-11-30
ES3046835T3 (en) 2025-12-02
EP2968211A4 (en) 2017-01-04
US9956197B2 (en) 2018-05-01
WO2014142518A1 (en) 2014-09-18
US9682059B2 (en) 2017-06-20
KR20170060168A (ko) 2017-05-31
JP6200526B2 (ja) 2017-09-20
JP2017206546A (ja) 2017-11-24
US20160023999A1 (en) 2016-01-28
JP2016512233A (ja) 2016-04-25
WO2014142477A1 (en) 2014-09-18
EP2968210A1 (en) 2016-01-20
EP2968212A4 (en) 2017-01-11
CN111419830B (zh) 2024-01-30
CN105228604A (zh) 2016-01-06
US20160024000A1 (en) 2016-01-28
CN111419830A (zh) 2020-07-17
EP2968213A1 (en) 2016-01-20

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