ES2982045T3 - Proceso para reducir la endotoxina presente en la gelatina - Google Patents
Proceso para reducir la endotoxina presente en la gelatina Download PDFInfo
- Publication number
- ES2982045T3 ES2982045T3 ES19727055T ES19727055T ES2982045T3 ES 2982045 T3 ES2982045 T3 ES 2982045T3 ES 19727055 T ES19727055 T ES 19727055T ES 19727055 T ES19727055 T ES 19727055T ES 2982045 T3 ES2982045 T3 ES 2982045T3
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- gelatin
- solution
- endotoxin
- salt
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 239000003326 hypnotic agent Substances 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
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- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- KHLVKKOJDHCJMG-QDBORUFSSA-L indigo carmine Chemical compound [Na+].[Na+].N/1C2=CC=C(S([O-])(=O)=O)C=C2C(=O)C\1=C1/NC2=CC=C(S(=O)(=O)[O-])C=C2C1=O KHLVKKOJDHCJMG-QDBORUFSSA-L 0.000 description 1
- 235000012738 indigotine Nutrition 0.000 description 1
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- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 1
- 235000013980 iron oxide Nutrition 0.000 description 1
- VBMVTYDPPZVILR-UHFFFAOYSA-N iron(2+);oxygen(2-) Chemical class [O-2].[Fe+2] VBMVTYDPPZVILR-UHFFFAOYSA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
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- 239000003589 local anesthetic agent Substances 0.000 description 1
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- 239000006166 lysate Substances 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
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- 229920000609 methyl cellulose Polymers 0.000 description 1
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- 239000003149 muscarinic antagonist Substances 0.000 description 1
- 150000002823 nitrates Chemical class 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000000014 opioid analgesic Substances 0.000 description 1
- 229940005483 opioid analgesics Drugs 0.000 description 1
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- 239000007935 oral tablet Substances 0.000 description 1
- 229940126578 oral vaccine Drugs 0.000 description 1
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- 238000007911 parenteral administration Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
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- 229920001983 poloxamer Polymers 0.000 description 1
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- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
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- 150000003384 small molecules Chemical class 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
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- 230000006641 stabilisation Effects 0.000 description 1
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- 235000002906 tartaric acid Nutrition 0.000 description 1
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- 235000010436 thaumatin Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09H—PREPARATION OF GLUE OR GELATINE
- C09H3/00—Isolation of glue or gelatine from raw materials, e.g. by extracting, by heating
- C09H3/02—Purification of solutions of gelatine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/08—Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/12—Macromolecular compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J47/00—Ion-exchange processes in general; Apparatus therefor
- B01J47/014—Ion-exchange processes in general; Apparatus therefor in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J47/00—Ion-exchange processes in general; Apparatus therefor
- B01J47/12—Ion-exchange processes in general; Apparatus therefor characterised by the use of ion-exchange material in the form of ribbons, filaments, fibres or sheets, e.g. membranes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862640394P | 2018-03-08 | 2018-03-08 | |
| PCT/IB2019/000234 WO2019171173A1 (en) | 2018-03-08 | 2019-03-07 | Process to reduce endotoxin in gelatin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2982045T3 true ES2982045T3 (es) | 2024-10-14 |
Family
ID=66668957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES19727055T Active ES2982045T3 (es) | 2018-03-08 | 2019-03-07 | Proceso para reducir la endotoxina presente en la gelatina |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10988638B2 (https=) |
| EP (1) | EP3761956B1 (https=) |
| JP (1) | JP7431741B2 (https=) |
| CN (1) | CN111902129A (https=) |
| AU (1) | AU2019229784A1 (https=) |
| BR (1) | BR112020015253A2 (https=) |
| CA (1) | CA3089172A1 (https=) |
| ES (1) | ES2982045T3 (https=) |
| IL (1) | IL277009B2 (https=) |
| MX (1) | MX2020009112A (https=) |
| WO (1) | WO2019171173A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL267689B2 (en) | 2016-12-31 | 2025-05-01 | Bioxcel Therapeutics Inc | Use of sublingual dexmedetomidine for the treatment of agitation |
| BR112020026672A2 (pt) | 2018-06-27 | 2021-03-30 | Bioxcel Therapeutics, Inc. | Formulações de filme contendo dexmedetomidina e métodos para produzi-las |
| BR112022000992A2 (pt) | 2019-07-19 | 2022-06-14 | Arx Llc | Regimes de tratamento de dexmedetomidina não sedantes |
| MY191879A (en) | 2019-07-31 | 2022-07-18 | Catalent Uk Swindon Zydis Ltd | Density flow meter for pharmaceutical formulation dosing |
| CN111286276A (zh) * | 2020-03-26 | 2020-06-16 | 吉林大学 | 一种林蛙皮明胶的制备方法 |
| WO2022103639A1 (en) | 2020-11-16 | 2022-05-19 | Orcosa Inc. | Methods of treating autoimmune or inflammatory conditions with cannabidiol or its derivatives/analogs |
| US11672761B2 (en) | 2020-11-16 | 2023-06-13 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
| CN113607903B (zh) * | 2021-07-30 | 2024-03-15 | 振德医疗用品股份有限公司 | 一种检测含有正电荷聚合物细菌内毒素的方法 |
| EP4501129A4 (en) | 2022-03-30 | 2026-03-11 | Toray Industries | PROCESS FOR THE PRODUCTION OF GELATIN OR A CONCENTRATED GELATIN SOLUTION |
| US11806334B1 (en) | 2023-01-12 | 2023-11-07 | Bioxcel Therapeutics, Inc. | Non-sedating dexmedetomidine treatment regimens |
| NL2038119B1 (en) * | 2024-07-02 | 2026-01-16 | Sentryx B V | A method for purifying a gelatin |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB211423A (en) | 1923-10-06 | 1924-02-21 | Leopold Seeger | Improved means for locking nuts |
| GB1548022A (en) | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
| CA1097233A (en) | 1977-07-20 | 1981-03-10 | George K. E. Gregory | Packages |
| US4374063A (en) | 1981-09-28 | 1983-02-15 | General Foods Corporation | Process for the preparation and purification of gelatin and pyrogen-free gelatin so prepared |
| IE53696B1 (en) | 1981-12-02 | 1989-01-18 | Wyeth John & Brother Ltd | Solid shaped articles |
| JP3039966B2 (ja) * | 1990-07-20 | 2000-05-08 | 新田ゼラチン株式会社 | ゼラチンのイオン性不純物除去方法 |
| JP4113580B2 (ja) * | 1994-02-07 | 2008-07-09 | キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング | エンドトキシンを減量又は除去する方法 |
| US5616689A (en) * | 1994-07-13 | 1997-04-01 | Collagen Corporation | Method of controlling structure stability of collagen fibers produced form solutions or dispersions treated with sodium hydroxide for infectious agent deactivation |
| GB9908014D0 (en) | 1999-04-08 | 1999-06-02 | Scherer Corp R P | Pharmaceutical compositions |
| RU2002112751A (ru) * | 1999-11-12 | 2004-02-27 | Файброджен, Инк. (Us) | Рекомбинантные желатины |
| DE10010342A1 (de) * | 2000-03-06 | 2001-09-20 | Merck Patent Gmbh | Verfahren zur Abreicherung von Endotoxinen |
| JP4762785B2 (ja) * | 2005-06-02 | 2011-08-31 | 西川ゴム工業株式会社 | ゼラチンスポンジ |
| JP5328077B2 (ja) | 2006-02-10 | 2013-10-30 | エア・ウォーター株式会社 | 低エンドトキシン化ゼラチンの製造方法 |
| JP4404866B2 (ja) * | 2006-03-03 | 2010-01-27 | ゼライス株式会社 | エンドトキシン含有量を低減したゼラチンの製造方法および低エンドトキシンゼラチン |
| JP4099541B2 (ja) | 2006-07-19 | 2008-06-11 | ゼライス株式会社 | ペプチド精製物の製造方法 |
| EP2409995A3 (en) * | 2007-02-28 | 2012-08-15 | Lipoxen Technologies Limited | Reduction of endotoxin in polysialic acids |
| CN102099379B (zh) * | 2008-06-19 | 2013-12-11 | 本德尔分析控股有限公司 | 用于从生物聚合物材料中去除杂质的方法 |
| US10548839B2 (en) | 2010-03-16 | 2020-02-04 | Wei Tian | Process of manufacturing a lyophilized fast dissolving, multi-phasic dosage form |
| CN102423721B (zh) * | 2011-08-18 | 2013-07-24 | 浙江工业大学 | 一种磁性阴离子交换剂及其作为内毒素吸附介质的应用 |
| US20140142200A1 (en) | 2012-11-16 | 2014-05-22 | Eyegenix LLC | Keratoprosthesis |
| CN104370997B (zh) * | 2014-09-24 | 2018-07-31 | 陈辉 | 去除生物制品中细菌内毒素的试剂盒、方法及其生物制品的制备方法 |
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2019
- 2019-03-07 ES ES19727055T patent/ES2982045T3/es active Active
- 2019-03-07 BR BR112020015253-6A patent/BR112020015253A2/pt not_active IP Right Cessation
- 2019-03-07 CA CA3089172A patent/CA3089172A1/en active Pending
- 2019-03-07 MX MX2020009112A patent/MX2020009112A/es unknown
- 2019-03-07 US US16/295,223 patent/US10988638B2/en active Active
- 2019-03-07 WO PCT/IB2019/000234 patent/WO2019171173A1/en not_active Ceased
- 2019-03-07 EP EP19727055.6A patent/EP3761956B1/en active Active
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- 2019-03-07 IL IL277009A patent/IL277009B2/en unknown
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- 2019-03-07 JP JP2020546887A patent/JP7431741B2/ja active Active
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2021
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|---|---|
| US10988638B2 (en) | 2021-04-27 |
| EP3761956C0 (en) | 2024-06-12 |
| US20210207003A1 (en) | 2021-07-08 |
| EP3761956B1 (en) | 2024-06-12 |
| JP2021516685A (ja) | 2021-07-08 |
| AU2019229784A1 (en) | 2020-08-13 |
| CA3089172A1 (en) | 2019-09-12 |
| MX2020009112A (es) | 2020-10-01 |
| EP3761956A1 (en) | 2021-01-13 |
| WO2019171173A1 (en) | 2019-09-12 |
| IL277009B2 (en) | 2024-06-01 |
| CN111902129A (zh) | 2020-11-06 |
| IL277009B1 (en) | 2024-02-01 |
| US20190276707A1 (en) | 2019-09-12 |
| JP7431741B2 (ja) | 2024-02-15 |
| BR112020015253A2 (pt) | 2020-12-08 |
| IL277009A (en) | 2020-10-29 |
| RU2020132925A (ru) | 2022-04-08 |
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