ES2980252T3 - Inhibidores de arginasa y sus métodos de uso - Google Patents
Inhibidores de arginasa y sus métodos de uso Download PDFInfo
- Publication number
- ES2980252T3 ES2980252T3 ES19758683T ES19758683T ES2980252T3 ES 2980252 T3 ES2980252 T3 ES 2980252T3 ES 19758683 T ES19758683 T ES 19758683T ES 19758683 T ES19758683 T ES 19758683T ES 2980252 T3 ES2980252 T3 ES 2980252T3
- Authority
- ES
- Spain
- Prior art keywords
- aza
- oxa
- hydroxy
- dodecan
- boraspiro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 title abstract description 14
- 102000004452 Arginase Human genes 0.000 title description 22
- 108700024123 Arginases Proteins 0.000 title description 22
- 239000003112 inhibitor Substances 0.000 title description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 43
- HMZBZPGFUGYYIH-UHIISALHSA-N (2S)-2-amino-N-[(3R,5R)-10-hydroxy-12-oxo-11-oxa-1-aza-10-boraspiro[4.7]dodecan-3-yl]-3-methylbutanamide Chemical compound N[C@H](C(=O)N[C@H]1CN[C@]2(C1)C(OB(CCCC2)O)=O)C(C)C HMZBZPGFUGYYIH-UHIISALHSA-N 0.000 claims abstract description 37
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 55
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- MVHFGAWLHMAREF-IIYDPXPESA-N (3R,5R)-3-[(4S)-2,2-dimethyl-5-oxo-4-propan-2-ylimidazolidin-1-yl]-10-hydroxy-11-oxa-1-aza-10-boraspiro[4.7]dodecan-12-one Chemical compound OB1OC([C@]2(C[C@H](CN2)N2C(N[C@H](C2=O)C(C)C)(C)C)CCCC1)=O MVHFGAWLHMAREF-IIYDPXPESA-N 0.000 abstract description 69
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US201862721113P | 2018-08-22 | 2018-08-22 | |
| PCT/EP2019/072341 WO2020038983A1 (en) | 2018-08-22 | 2019-08-21 | Arginase inhibitors and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2980252T3 true ES2980252T3 (es) | 2024-09-30 |
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| EP (2) | EP4371614A3 (https=) |
| JP (1) | JP7441210B2 (https=) |
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| MA (1) | MA53427B1 (https=) |
| MX (1) | MX2021002042A (https=) |
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| PT (1) | PT3840837T (https=) |
| RS (1) | RS65608B1 (https=) |
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| SI (1) | SI3840837T1 (https=) |
| SM (1) | SMT202400221T1 (https=) |
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| TWI877770B (zh) | 2018-02-27 | 2025-03-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之咪唑并嘧啶及三唑并嘧啶 |
| EP3810610A1 (en) | 2018-05-18 | 2021-04-28 | Incyte Corporation | Fused pyrimidine derivatives as a2a / a2b inhibitors |
| WO2020010197A1 (en) | 2018-07-05 | 2020-01-09 | Incyte Corporation | Fused pyrazine derivatives as a2a / a2b inhibitors |
| TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
| PH12021551902A1 (en) * | 2019-02-08 | 2022-08-01 | Astrazeneca Ab | Arginase inhibitors and methods of use thereof |
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| SG10201503168VA (en) * | 2010-04-22 | 2015-06-29 | Mars Inc | Inhibitors of arginase and their therapeutic applications |
| US10143699B2 (en) * | 2015-06-23 | 2018-12-04 | Calithera Biosciences, Inc. | Compositions and methods for inhibiting arginase activity |
| JP2020502259A (ja) * | 2016-11-08 | 2020-01-23 | カリセラ バイオサイエンシズ，インコーポレイテッド | アルギナーゼ阻害剤併用療法 |
| CN114989205A (zh) | 2016-12-22 | 2022-09-02 | 卡里塞拉生物科学股份公司 | 用于抑制精氨酸酶活性的组合物和方法 |
| CN117186134A (zh) | 2018-02-17 | 2023-12-08 | 阿斯利康(瑞典)有限公司 | 精氨酸酶抑制剂及其使用方法 |
| EP3765006A4 (en) | 2018-03-13 | 2022-02-23 | Merck Sharp & Dohme Corp. | ARGINASE INHIBITORS AND METHODS OF USE |
| CN111770756B (zh) | 2018-04-27 | 2023-03-31 | 四川科伦博泰生物医药股份有限公司 | 非天然氨基酸类衍生物、包含其的药物组合物及其制备方法和用途 |
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- 2019-08-21 PL PL19758683.7T patent/PL3840837T3/pl unknown
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2021
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